Pathogenesis and treatment in spinal cord injury without bony disruption
Project/Area Number |
21591876
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Cerebral neurosurgery
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Research Institution | Yokohama City University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KANNO Hiroshi 横浜市立大学, 医学研究科, 客員准教授 (40244496)
|
Co-Investigator(Renkei-kenkyūsha) |
KIM Phyo 獨協医科大学, 医学研究科, 教授 (90231290)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脊髄損傷 / 病態 / 治療 / 神経再生 / 再生 |
Research Abstract |
Spinal cord injury without bony disruption is common. Elderly people get it easily because they sometimes have chronic spinal cord compression such as cervical spondylosis, cervical disc hernia and ossification of posterior longitudinal ligament. Dynamic neck movement including hyperextension induces this indirect spinal cord injury, which doesn' t often cause bony fracture and dislocation. The mechanism and pathogenesis is not really clear yet. We created the rat model with spinal cord injury with bony disruption, which was induced by cervical hyperextension under the chronic compression of spinal cord. We found that the spinal cord injury without bony disruption depends on potential compressive degeneration of spinal cord as well as actual impact to spinal cord. This phenomenon can explain clinical heterogeneity of spinal cord injury without bony disruption. We are analyzing optimal treatment for spinal cord injury without bony disruption.
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Report
(4 results)
Research Products
(11 results)
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[Presentation] 脊椎脊髄由来の痛みとそのマネージメント2010
Author(s)
村田英俊, 高瀬創, 佐藤充, 安久正哲, 吉川信一朗, 立石健祐, 横山高玲, 菅野洋, 川原信隆
Organizer
Authentic Spinal Surgeon Summit
Place of Presentation
東京
Year and Date
2010-03-20
Related Report
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[Presentation] 脊椎脊髄損傷の病態とその痛みのマネージメント2010
Author(s)
村田英俊, 高瀬創, 佐藤充安, 久正哲, 吉川信一朗, 立石健祐, 横山高玲, 菅野洋, 川原信隆
Organizer
Authentic Spinal Surgeon Summit
Place of Presentation
東京
Year and Date
2010-03-20
Related Report
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