Analysis of Wnt pathway in intracranial germ cell tumors

• Project/Area Number: 21591877
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cerebral neurosurgery
• Research Institution: Saitama Medical University
• Principal Investigator: MATSUTANI Masao 埼玉医科大学, 医学部, 名誉教授 (90010454)
• Co-Investigator(Kenkyū-buntansha): NISHIKAWA Ryo 埼玉医科大学, 医学部, 教授 (90237678)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 胚細胞腫瘍 / 腫瘍マーカー / 胚細胞腫 / 癌 / 脳・神経 / シグナル伝達 / シグナル伝逹

Research Abstract

We analyzed expression of the major molecules involved in the Wnt signal pathway in intracranial germ cell tumors using immunohistochemical technique. ss-catenin was suggested to be a novel tumor marker for immature teratoma. There was not a significant trend of expression in the other molecules analyzed.