Development of functional brain treatment system by integrating white matter tractographies of the brain
| Project/Area Number |
21591881
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KURITA Hiroki 埼玉医科大学, 医学部, 教授 (70262003)
KAMADA Kyousuke 旭川医科大学, 医学部, 教授 (80372374)
KOGA Tomoyuki 埼玉医科大学, 医学部, 助教 (40456124)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | MRI / 拡散テンソル / 定位放射線治療 / 手術支援 / 弓状束 / 言語機能 |
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| Research Abstract |
After imaging processing of diffusion tensor tractography derived from the brain MRI, tractography was integrated to treatment planning software for stereotactic radiosurgery of the brain as well as neuronavigation system for microsurgery. As a result, we found that stereotactic irradiation of 10Gy to the temporal fibers of the arcuate fasciculus caused language disturbance, while that to the frontal fibers did not. If the dose to the pyramidal tract was set within 20 Gy, the optic radiation and the temporal fibers of the arcuate fasciculus within 8 Gy, and the frontal fibers of the arcuate fasciculus within 20 Gy during stereotactic radiosurgery, the rate of complication could extremely be reduced. By its integration to neuronavigation, we found linear relationship between the intensity of electrical stimulation and the distance to the pyramidal tract.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Outcomes of diffusion-tensor tractography-integrated stereotactic radiosurgery2012
Author(s)
Koga T, Maruyama K, Kamada K, Ota T, Shin M, Itoh D, Kunii N, Ino K, Terahara A, Aoki S, Masutani Y, Saito N
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82
Pages: 799-802
Related Report
Peer Reviewed
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[Journal Article] Integration of Corticospinal Tractography Reduces Motor Complications After Radiosurgery2011
Author(s)
Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: (on line)
Issue: 1
Pages: 1-5
DOI
Related Report
Peer Reviewed
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[Journal Article] Arcuate fasciculus tractography integrated into gamma knife surgery2009
Author(s)
Maruyama K, Koga T, Kamada K, Ota T, Itoh D, Ino K, Igaki H, Aoki S, Masutani Y, Shin M, Saito N
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Journal Title
J Neurosurg
Volume: 111
Pages: 520-526
Related Report
Peer Reviewed
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[Journal Article] Long-term control of disseminated pleomorphic xanthoastrocytoma with anaplastic features by means of stereotactic irradiation2009
Author(s)
Koga T, Morita A, Maruyama K, Tanaka M, Ino Y, Shibahara J, Louis DN, Reifenberger G, Itami J, Hara R, Saito N, Todo T
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Journal Title
Neurooncology
Volume: 11
Pages: 446-451
Related Report
Peer Reviewed
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[Journal Article] 脳内出血2009
Author(s)
丸山啓介
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Journal Title
Current Insights in Neurological Science
Volume: 17(3)
Pages: 6-6
Related Report
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[Journal Article] Integration of corticospinal tractography reduces motor complications after radiosurgery
Author(s)
Koga T, Shin M, Maruyama K, Kamada K, Ota T, Itoh D, Kunii N, Ino K, Aoki S, Masutani Y, Igaki H, Onoe T, Saito N
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: (in press)
Related Report
Peer Reviewed
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