| Project/Area Number |
21591884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Yoichi 日本大学, 医学部, 教授 (00125048)
FUKAYA Chikashi 日本大学, 医学部, 准教授 (50287637)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 機能脳神経外科学 / 振戦 / 脊髄刺激 / 脳深部刺激 / 疼痛 / 脳卒中後疼痛 / 企図振戦 / ケタミン / ドラッグチャレンジテスト / dual-lead / spinal cord stimulation / deep brain stimulation / drug challenge test / post-stroke pain / essential tremor / 痛み / 外科 / 生理学 / 神経科学 / 脳・神経 / 脳神経疾患 |
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| Research Abstract |
We have examined the usefulness of dual-lead stimulation in cerebrospinal stimulation therapy. Dual-lead cervical spinal cord stimulation(SCS) was useful for the treatment of post-stroke pain. Dual-lead stimulation of thalamic Vim/Vop and subthalamic area showed remarkable suppression of intractable tremor. Dual-lead thalamic Vc nucleus stimulation was useful for the treatment of neuropathic pain. Dual-lead Motor cortex stimulation(MCS) could be a new therapeutic approach to improving motor performance after stroke by attenuating rigidity and/or spasticity. However, it may be important to define the appropriate number of hours and conditions of daily MCS.
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