Analysis of abnormal cell polarity in brain tumor cells
| Project/Area Number |
21591887
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Aichi Cancer Center Research Institute |
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Principal Investigator |
IZAWA Ichiro 愛知県がんセンター(研究所), 発がん制御研究部, 室長 (20311441)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 細胞極性 / 細胞接着 / 脳神経疾患 / シグナル伝達 / 脳腫瘍 |
|---|
| Research Abstract |
To study the phenotype of glioma, a representative brain tumor, from the point of view of the regulation of cell polarity, we studied LAP family proteins(human ERBIN and Scribble), which are known to regulate cell polarity. We identified several proteins as binding partners of human Scribble by a yeast two-hybrid screening. We found that Scribble interacts with p0071 and MRP4 via the PDZ domain, co-localizes with these proteins at the basolateral membrane, and may regulate functions of these proteins.
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Report
(4 results)
Research Products
(7 results)
