| Project/Area Number |
21591888
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | National Hospital Organization Osaka National Hospital Institute for Clinical Reserch |
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Principal Investigator |
KANEMURA Yonehiro 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 先進医療研究開発部再生医療研究室, 室長 (80344175)
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| Co-Investigator(Kenkyū-buntansha) |
SHOFUDA Tomoko 独立行政法人国立病院機構大阪医療センター(臨床研究センター), 先進医療研究開発部・幹細胞医療研究室, 室長 (40450895)
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| Co-Investigator(Renkei-kenkyūsha) |
MORIUCHI Shusuke りんくう総合医療センター, 脳神経外科, 部長 (90322180)
NAITO Takeaki 神戸薬科大学, 薬学部, 教授 (00068339)
MIYATA Okiko 神戸薬科大学, 薬学部, 教授 (90102110)
ARITA Norio 兵庫医科大学, 医学部, 教授 (80159508)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脳腫瘍学 / グリオーマ幹細胞 / 脳神経疾患 / 薬剤反応性 / 癌 |
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| Research Abstract |
In this research, to develop new drugs for malignant gliomas(MGs), we examined the in vitro chemosensitivity of glioma stem cells(GSCs) compared with normal neural stem cells(NSCs), which we used in vitro model cells for drug screening and toxicity studies. We isolated three GSC lines isolated from surgically removed MG tissues and examined their detailed in vitro cellular properties. In vitro chemosensitivity to drugs for MGs(ACNU, TMZ, INF-β, VCR, PCZ) or other compounds against GSCs and NSCs were examined. We found that both GSCs and NSCs showed similar chemosensitivities and several compounds showed significant cytotoxic effect to GCSs and NSCs equally. These findings will increase our knowledge about the cellular properties of GSCs and provide useful information for the development of new drugs that target GSCs.
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