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Patho-mechanism of discogenic low back pain

Research Project

Project/Area Number 21591891
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionChiba University

Principal Investigator

TAKAHASHI Kazuhisa  千葉大学, 大学院・医学研究院, 教授 (20179477)

Co-Investigator(Kenkyū-buntansha) OTORI Seiji  千葉大学, 大学院・医学研究院, 助教 (40361430)
高相 晶士  北里大学, 医学部附属病院, 准教授 (90439117)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords椎間板 / 腰痛 / 細胞内シグナル / サイトカイン / 感覚神経
Research Abstract

SUMMARY OF BACKGROUND DATA : BDNF-a neurotrophin in DRG neurons-is anterogradely transported to the spinal cord and transmits pain signals. Its presence in the peripheral sites of degenerative IVDs has been recently reported, although its association with discogenic pain remains unclear. Direct intradiscal application of the anti-BDNF antibody significantly suppressed both CGRP production and the local concentration of BDNF. Our results indicate a possible association between the local production of BDNF and the pathophysiology of discogenic pain.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 2010 2009

All Journal Article (6 results) (of which Peer Reviewed: 6 results)

  • [Journal Article] Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats2011

    • Author(s)
      Orita S, Eguchi Y, Kamoda H, Arai G, Ishikawa T, Miyagi M, Inoue G, Suzuki M, Toyone T, Aoki Y, Takahashi K, Ohtori S
    • Journal Title

      Spine (Phila Pa1976)

      Volume: 36(21) Pages: 1737-43

    • NAID

      10031165937

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons2011

    • Author(s)
      Horii M, Orita S, Nagata M, Takaso M, Yamauchi K, Yamashita M, Inoue G, Eguchi Y, Ochiai N, Kishida S, Aoki Y, Ishikawa T, Arai G, Miyagi M, Kamoda H, Kuniyoshi K, Suzuki M, Nakamura J, Toyone T, Takahashi K, Ohtori S
    • Journal Title

      Spine

      Volume: 36

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats2011

    • Author(s)
      Orita S, et al.
    • Journal Title

      SPINE

      Volume: 36 Pages: 1737-43

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model2010

    • Author(s)
      Fukui Y, Ohtori S, Yamashita M, Yamauchi K, Inoue G, Suzuki M, Orita S, Eguchi Y, Ochiai N, Kishida S, Takaso M, Wakai K, Hayashi Y, Aoki Y, Takahashi K
    • Journal Title

      J Orthop Res

      Volume: 28 Pages: 279-83

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effectiveness of L2 spinal nerve infiltration for selective discogenic low back pain patients.2010

    • Author(s)
      Ohtnri S, et al.
    • Journal Title

      J Orthop Sci.

      Volume: 15 Pages: 731-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Results of surgery for discogenic low back pain : a randomized study using discography versus discoblock for diagnosis.2009

    • Author(s)
      Ohtori S, et al.
    • Journal Title

      SPINE 34

      Pages: 1435-8

    • NAID

      10027243675

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed

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Published: 2009-04-01   Modified: 2016-04-21  

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