Patho-mechanism of discogenic low back pain

• Project/Area Number: 21591891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Chiba University
• Principal Investigator: TAKAHASHI Kazuhisa 千葉大学, 大学院・医学研究院, 教授 (20179477)
• Co-Investigator(Kenkyū-buntansha): OTORI Seiji 千葉大学, 大学院・医学研究院, 助教 (40361430) ; 高相 晶士 北里大学, 医学部附属病院, 准教授 (90439117)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 椎間板 / 腰痛 / 細胞内シグナル / サイトカイン / 感覚神経

Research Abstract

SUMMARY OF BACKGROUND DATA : BDNF-a neurotrophin in DRG neurons-is anterogradely transported to the spinal cord and transmits pain signals. Its presence in the peripheral sites of degenerative IVDs has been recently reported, although its association with discogenic pain remains unclear. Direct intradiscal application of the anti-BDNF antibody significantly suppressed both CGRP production and the local concentration of BDNF. Our results indicate a possible association between the local production of BDNF and the pathophysiology of discogenic pain.

Research Products

• [Journal Article] Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats (2011)
  • Author(s): Orita S, Eguchi Y, Kamoda H, Arai G, Ishikawa T, Miyagi M, Inoue G, Suzuki M, Toyone T, Aoki Y, Takahashi K, Ohtori S
  • Journal Title: Spine (Phila Pa1976) Volume: 36(21) Pages: 1737-43
  • NAID: 10031165937
  • Peer Reviewed
• [Journal Article] Direct Application of the Tumor Necrosis Factor-α Inhibitor, Etanercept, Into a Punctured Intervertebral Disc Decreases Calcitonin Gene-Related Peptide Expression in Rat Dorsal Root Ganglion Neurons (2011)
  • Author(s): Horii M, Orita S, Nagata M, Takaso M, Yamauchi K, Yamashita M, Inoue G, Eguchi Y, Ochiai N, Kishida S, Aoki Y, Ishikawa T, Arai G, Miyagi M, Kamoda H, Kuniyoshi K, Suzuki M, Nakamura J, Toyone T, Takahashi K, Ohtori S
  • Journal Title: Spine Volume: 36
  • Peer Reviewed
• [Journal Article] Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats (2011)
  • Author(s): Orita S, et al.
  • Journal Title: SPINE Volume: 36 Pages: 1737-43
  • Peer Reviewed
• [Journal Article] Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model (2010)
  • Author(s): Fukui Y, Ohtori S, Yamashita M, Yamauchi K, Inoue G, Suzuki M, Orita S, Eguchi Y, Ochiai N, Kishida S, Takaso M, Wakai K, Hayashi Y, Aoki Y, Takahashi K
  • Journal Title: J Orthop Res Volume: 28 Pages: 279-83
  • Peer Reviewed
• [Journal Article] Effectiveness of L2 spinal nerve infiltration for selective discogenic low back pain patients. (2010)
  • Author(s): Ohtnri S, et al.
  • Journal Title: J Orthop Sci. Volume: 15 Pages: 731-6
  • Peer Reviewed
• [Journal Article] Results of surgery for discogenic low back pain : a randomized study using discography versus discoblock for diagnosis. (2009)
  • Author(s): Ohtori S, et al.
  • Journal Title: SPINE 34 Pages: 1435-8
  • NAID: 10027243675
  • Peer Reviewed