Improvement of functional recovery and promotion of remyelination by cell transplantation and scaffold at the chronic phase after spinal cord injury
| Project/Area Number |
21591894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ENOMOTO Mitsuhiro 東京医科歯科大学, 大学院・医歯学総合研究科, 寄附講座教員 (90451971)
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| Co-Investigator(Kenkyū-buntansha) |
WAKABAYASHI Yoshiaki 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (00431916)
SOTOME Shinichi 東京医科歯科大学, 大学院・医歯学総合研究科, 寄付講座准教授 (20401391)
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| Co-Investigator(Renkei-kenkyūsha) |
SHINOMIYA Kenichi 東京医科歯科大学, 大学院・医歯学総合研究科, 名誉教授 (20111594)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脊髄損傷 / 神経再生 / 神経栄養因子 / 神経幹細胞 / 移植 / 担体 |
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| Research Abstract |
In this study, neural progenitor cells(NPCs) or bone marrow stromal cells(BMCs) combined with honeycomb collagen scaffold(HC) were transplanted into the injured spinal cord. HC with NPCs were implanted into contused spinal cord at six weeks after the initial thoracic injury. T
he functional recovery was little shown in the both implanted groups. On the other hand, rats implanted with HC containing BMCs displayed better hindlimb function and hypersensitivity than those implanted with HC without BMCs in the hemisected model. The implanted area exhibited more nerve fibers than the areas not containing BMCs. These effects result from the presence of BMCs that directly promote nerve regeneration. However, most of spinal cord injury patients have already paralyzed and maintained into chronic phase of recovery. Further treatments such as resection of scar tissue, developments of transplantation technique or rehabilitation would be needed to promote functional recovery at the chronic phase after spinal cord injury.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Non-human primate model of amyotrophiclateral sclerosis with cytoplasmic mislocalization of TDP-432012
Author(s)
Uchida A, Sasaguri H, Kimura N, TajiriM, Ohkubo T, Ono F, Sakaue F, Kanai K, Hirai T, Sano T, Shibuya K, Kobayashi M, Yamamoto M, Yokota S, Kubodera T, Tomori M, Sakaki K, Enomoto M, Hirai Y, Kumagai J, Yasutomi Y, Mochizuki H, Kuwabara S, Uchihara T, Mizusawa H, Yokota T
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Journal Title
Brain
Volume: 135(Pt3)
Pages: 833-46
Related Report
Peer Reviewed
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[Journal Article] Middle-term results of a prospective comparative study of anteriorde compression with fusion and posterior decompression with laminoplasty for thetreatment of cervical spondylotic myelopathy2011
Author(s)
Hirai T, Okawa A, Arai Y, Takahashi M, Kawabata S, Kato T, Enomoto M, Tomizawa S, Sakai K, Torigoe I, Shinomiya K
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Journal Title
Spine(Phila Pa1976)
Volume: 36(23)
Pages: 1940-7
Related Report
Peer Reviewed
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[Journal Article] Middle-Term Results of a Prospective Comparative Study of Anterior Decompression with Fusion and Posterior Decompression with Laminoplasty for the Treatment of Cervical Spondylotic Myelopathy2011
Author(s)
T.Hirai, A.Okawa, Y.Arai, M.Takahashi, S.Kawabata, T.Kato, M.Enomoto, S.Tomizawa, K.Sakai, I.Torigoe, K.Shinomiya
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Journal Title
NAID
Related Report
Peer Reviewed
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