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Proteomic analysis for the degenerative changes of yellow ligament

Research Project

Project/Area Number 21591902
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionNagoya City University

Principal Investigator

OGIKUBO Osamu  名古屋市立大学, 大学院・医学研究科, 研究員 (00291584)

Co-Investigator(Kenkyū-buntansha) HAYASHI Yoshimi  名古屋市立大学, 大学院・医学研究科, 研究員 (80444967)
Co-Investigator(Renkei-kenkyūsha) OHKUBO Iwao  天使大学, 看護栄養学部, 教授 (80152073)
TAKEUCHI Keisuke  滋賀医科大学, 医学部, 助教 (40432306)
ISHIGURO Hiroshi  岐阜医療科学大学, 保健科学部, 教授 (20211039)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsプロテオーム解析 / プロテアーゼ / インヒビター / 靱帯 / 変性肥厚 / 脂質代謝 / メタボリック症候 / 靭帯 / メタボリック症候群 / 肥満
Research Abstract

The mechanism of the degenerative thickening of yellow ligament was investigated by proteomic analysis. We demonstrated some multifunctional plasma proteins, such as Zn-α2-glycoprotein, amyloid P component, in the pathological focus of the degenerative yellow ligament histochemically.
On the other hand, we could construct the quantitative analysis system of ZAG to confirm the function of this protein.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2010 2009

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] A Rare Case of Extramedullary-Intradural Hemangioblastoma in the Thoracic Spine2009

    • Author(s)
      Taniguchi S, Ogikubo O, Nakamura T, et al.
    • Journal Title

      Spine

      Volume: 34(26)

    • Related Report
      2011 Final Research Report
  • [Presentation] 血漿Zn-α2-glycoprotein測定値と肥満との相関について2010

    • Author(s)
      竹内圭介、林良美、荻久保修、大塚隆信、大久保岩男
    • Organizer
      第83回日本生化学学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] 血漿Zn-α2-glycoprotein測定値と肥満との相関について2010

    • Author(s)
      林良美, 他
    • Organizer
      第83回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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