Positive Effect on Bone Fusion by the Combination of Platelet-Rich Plasma and a Gelatinβ-Tricalcium Phosphate Sponge : A Study Using a Posterolateral Fusion Model of Lumbar Vertebrae in Rats
| Project/Area Number |
21591903
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HASE Hitoshi 京都府立医科大学, 医学研究科, 准教授 (00172883)
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| Co-Investigator(Kenkyū-buntansha) |
MIKAMI Yasuo 京都府立医科大学, 医学研究科, 講師 (80360030)
IKEDA Takumi 京都府立医科大学, 医学研究科, 助教 (40453120)
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| Research Collaborator |
OKAMOTO Shinichi 京都府立医科大学, 医学研究科, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 多血小板血漿 / ゼラチンβ-TCPスポンジ / 脊椎固定術 / ゼラチンβTCPスポンジ / 骨癒合 |
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| Research Abstract |
The positive effect on bone fusion using the combination of PRP and the gelatinβ-TCP sponge is equivalent to that of autogenous bone grafting. This method might be less invasive than autogenous bone grafting in terms of being able to induce bone fusion by autologous blood without impairing of healthy donor site. This method also has the advantage of being very safe to perform, because all these materials have already been extensively used clinically. The current study demonstrates that the bone fusion method using the combination of PRP and the gelatinβ-TCP sponge could be an alternative to autogenous bone grafting in terms of its effectiveness, lower invasiveness, and safety.
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Report
(4 results)
Research Products
(5 results)
