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Positive Effect on Bone Fusion by the Combination of Platelet-Rich Plasma and a Gelatinβ-Tricalcium Phosphate Sponge : A Study Using a Posterolateral Fusion Model of Lumbar Vertebrae in Rats

Research Project

Project/Area Number 21591903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

HASE Hitoshi  京都府立医科大学, 医学研究科, 准教授 (00172883)

Co-Investigator(Kenkyū-buntansha) MIKAMI Yasuo  京都府立医科大学, 医学研究科, 講師 (80360030)
IKEDA Takumi  京都府立医科大学, 医学研究科, 助教 (40453120)
Research Collaborator OKAMOTO Shinichi  京都府立医科大学, 医学研究科, 大学院生
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords多血小板血漿 / ゼラチンβ-TCPスポンジ / 脊椎固定術 / ゼラチンβTCPスポンジ / 骨癒合
Research Abstract

The positive effect on bone fusion using the combination of PRP and the gelatinβ-TCP sponge is equivalent to that of autogenous bone grafting. This method might be less invasive than autogenous bone grafting in terms of being able to induce bone fusion by autologous blood without impairing of healthy donor site. This method also has the advantage of being very safe to perform, because all these materials have already been extensively used clinically. The current study demonstrates that the bone fusion method using the combination of PRP and the gelatinβ-TCP sponge could be an alternative to autogenous bone grafting in terms of its effectiveness, lower invasiveness, and safety.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Positive Effect on Bone Fusion by the Combination of Platelet-Rich Plasma and a Gelatinβ-Tricalcium Phosphate Sponge : A Study Using a Posterolateral Fusion Model of Lumbar Vertebrae in Rats2011

    • Author(s)
      岡本慎一, 池田巧, 長谷斉, 三上靖夫, 他7名
    • Journal Title

      TISSUE ENGINEERING : Part A

      Volume: Volume 18 Pages: 157-166

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 多血小板血漿とゼラチンβ-TCPスポンジを組み合わせた骨癒合法の有効性-自家骨移植との比較による骨癒合過程の検討-2011

    • Author(s)
      岡本慎一, 池田巧, 長谷斉, 三上靖夫, 他7名
    • Journal Title

      TISSUE ENGINEERING : Part A

      Volume: Volume 00 Pages: 1-10

    • Related Report
      2011 Annual Research Report
  • [Presentation] 多血小板血漿とゼラチンβ-TCPスポンジを組み合わせた骨癒合法の有性-自家骨移植との比較による骨癒合過程の検討-2011

    • Author(s)
      岡本慎一
    • Organizer
      第26回日本整形外科学会基礎学術総会
    • Place of Presentation
      群馬
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 多血小板血漿とゼラチンβ-TCPスポンジを組み合わせた骨癒合法の有効性-自家骨移植との比較による骨癒合過程の検討-2011

    • Author(s)
      岡本慎一, 池田巧, 長谷斉, 三上靖夫, 他7名
    • Organizer
      第26回日本整形外科学会基礎学術総会
    • Place of Presentation
      群馬
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多血小板血漿とゼラチンβ-TCPスポンジが骨癒合におよぼす影響ラット腰椎後側方固定モデルでの検討2010

    • Author(s)
      岡本慎一, 池田巧, 他
    • Organizer
      第25回日本整形外科学会基礎学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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