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Development of chelate-setting cements for bone grafting

Research Project

Project/Area Number 21591905
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionKeio University

Principal Investigator

MATSUMOTO Morio  慶應義塾大学, 医学部, 准教授 (40209656)

Co-Investigator(Kenkyū-buntansha) AIZAWA Mamoru  明治大学, 理工学部, 教授 (10255713)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords移植・再生医療 / 再生医学 / 臨床 / 骨移植 / 脊椎固定術
Research Abstract

We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite particles surface-modified with inositol phosphate. As we have examined the biocompatibility of this apatite cement, it showed good cell differentiation, attachment and proliferation, and bone induction both In vitro and In vivo. Thus, this present study demonstrates that this apatite cement can be useful as a new bone substitute for bone grafting in the spine.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2012 2011 2010 2009

All Journal Article (8 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging2012

    • Author(s)
      H. Funao, K. Ishii, S. Nagai, A. Sasaki, T. Hoshikawa, M. Aizawa, Y. Okada, K. Chiba, S. Koyasu, Y. Toyama and M. Matsumoto
    • Journal Title

      Infection and Immunity

      Volume: 80 Pages: 733-741

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 低侵襲治療を指向したペースト状人工骨の開発2012

    • Author(s)
      相澤守, 小西敏功, 松本守雄
    • Journal Title

      工業材料

      Volume: (印刷中) Pages: 60-60

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a Real-Time, Quantitative and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescience Imaging2012

    • Author(s)
      H.Funao, K.Ishii, M.Aizawa, M.Matsumoto, et al
    • Journal Title

      Infection And Immunity

      Volume: 80 Pages: 733-741

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低侵襲治療を施行したペースト状人工骨の開発2012

    • Author(s)
      相澤守, 小西敏功, 松本守雄
    • Journal Title

      工業材料

      Volume: 60(印刷中)

    • Related Report
      2011 Annual Research Report
  • [Journal Article] キレート硬化型骨修復セメントの開発2010

    • Author(s)
      相澤守, 小西敏功, 松本守雄
    • Journal Title

      CERAMIC DATA BOOK

      Volume: 38 Pages: 201-205

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Development of Apatite-Fiber Scaffold with Enhanced Mechanical Property via Uniaxial Pressing and Their Biocompatibility.2009

    • Author(s)
      S.Motojima, M.Matsumoto, M.Aizawa, et al.
    • Journal Title

      Bioceramics 22

      Pages: 177-180

    • Related Report
      2009 Annual Research Report
  • [Journal Article] In Vitro and in vivo evaluation of chelate-setting β-tricalcium phosphate cements using inositol phosphate.2009

    • Author(s)
      K.Nishiyama, M.Matsumoto, M.Aizawa, et al.
    • Journal Title

      Bioceramics 22

      Pages: 871-874

    • Related Report
      2009 Annual Research Report
  • [Journal Article] In vivo bone formation using three-dimensional scaffolds developed from a single crystal apatite fiber.2009

    • Author(s)
      H.Morisue, M.Matsumoto, M.Aizawa, et al.
    • Journal Title

      J.Biomed.Mater.Res.A 90A

      Pages: 811-818

    • Related Report
      2009 Annual Research Report
  • [Presentation] キトサンを添加したインジェクション型アパタイトセメントのウサギ脛骨への埋入による硬組織適合性評価2012

    • Author(s)
      水本みのり・小西敏功・本田みちよ・石井賢・船尾陽生・戸山芳昭・松本守雄・相澤守
    • Organizer
      日本セラミックス協会2012年年会、日本セラミックス協会
    • Place of Presentation
      京都大学吉田キャンパス
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトから作製したキレート硬化型セメントの生体適合性評価2011

    • Author(s)
      千布悠貴・小西敏功・水本みのり・本田みちよ・松本守雄・石井賢・相澤守
    • Organizer
      第33回日本バイオマテリアル学会大会、日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 超音波噴霧熱分解法により合成した銀担持ハイドロキシアパタイト微小球の抗菌性評価2011

    • Author(s)
      川延勇介・本田みちよ・水本みのり・小西敏功・羽太優理・神澤信行・石井賢・松本守雄・相澤守
    • Organizer
      第33回日本バイオマテリアル学会大会、日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨軟部耐性菌感染症に対する新規分子標的治療法の開発-抗生物質ターゲッティング療法2011

    • Author(s)
      蔵本哲也・石井賢・永井重徳・船尾陽生・相澤守・平井政彦・佐々木文・岡田保典・千葉一裕・小安重夫・戸山芳昭・松本守雄
    • Organizer
      第33回日本バイオマテリアル学会大会、日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 抗生物質ターゲッティング療法の確立へ向けた抗生剤含有・炎症プローブの開発2011

    • Author(s)
      蔵本哲也・石井賢・平井政彦・船尾陽生・永井重徳・相澤守・佐々木文・岡田保典・千葉一裕・小安重夫・戸山芳昭・松本守雄
    • Organizer
      第33回日本バイオマテリアル学会大会、日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨ミネラル含有アパタイトから作製したキレート硬化型セメントのウサギ脛骨埋入による組織学的評価2011

    • Author(s)
      千布悠貴・小西敏功・水本みのり・本田みちよ・松本守雄・石井賢・相澤守
    • Organizer
      日本セラミックス協会秋季シンポジウム
    • Place of Presentation
      北海道大学(札幌キャンパス)
    • Related Report
      2011 Annual Research Report
  • [Presentation] IN VIVO EVALUATION OF BIODEGRADABLE □-TRICALCIUM PHOS PHATE / POLY-(L-LACTIC ACID) HYBRIDS USING RABBIT MODEL2010

    • Author(s)
      Y.SHIGEMITSU, Y.IWAMOTO, K.ORIBE, N.SUGIYAMA, Y.TAKEOKA, M.RIKUKAWA, M.MATSUMOTO, H.MORISUE, Y.TOYAMA, M.AIZAWA
    • Organizer
      THE 3RD INTERNATIONAL CONGRESS ON CERAMICS (ICC3)
    • Place of Presentation
      Osaka
    • Related Report
      2010 Annual Research Report
  • [Presentation] IN VIVO EVALUATION OF CHELATE-SETTING CALCIUM-PHOSPHATE CEMENTS WITH VARIOUS BIORESORBABILITY USING RABBIT MODEL2010

    • Author(s)
      T.KONISHI, S.TAKAHASHI, M.MIZUMOTO, S.SATO, M.HONDA, K.KIDA, Y.HORIGUCHI, K.ORIBE, H.MORISUE, Y.TOYAMA, M.MATSUMOTO, M.AIZAWA
    • Organizer
      THE 3RD INTERNATIONAL CONGRESS ON CERAMICS
    • Place of Presentation
      Osaka
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Novel Calcium-phosphate Cements on the Basis of Chelate-setting Mechanism of Inositol Phosphate2010

    • Author(s)
      M.Aizawa, T.Konishi, K.Kida, K.Oribe, H.Morisue, Y.Toyama, M.Matsumoto
    • Organizer
      FOURTH INTERNATIONAL CONFERENCE ON SCIENCE AND TECHNOLOGY OF ADVANCED CERAMICS
    • Place of Presentation
      Yokohama
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体吸収性の異なるキレート硬化型骨修復セメントの生体内反応2010

    • Author(s)
      相澤守, 小西敏功, 木田弘毅, 高橋周平, 織部一弥, 森末光, 戸山芳昭, 松本守雄
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] アパタイトファイバースキャフォルドの創製と硬組織再生2009

    • Author(s)
      相澤守, 松本守雄
    • Organizer
      第18回硬組織再生生物学会
    • Place of Presentation
      北海道医療大学札幌サテライトキャンパス
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report
  • [Patent(Industrial Property Rights)] 板状ヒドロキシアパタイト単結晶の製造方法2009

    • Inventor(s)
      相澤守
    • Industrial Property Rights Holder
      学校法人明治大学
    • Industrial Property Number
      2009-057161
    • Filing Date
      2009-05-20
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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