Development of chelate-setting cements for bone grafting
Project/Area Number |
21591905
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Keio University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
AIZAWA Mamoru 明治大学, 理工学部, 教授 (10255713)
|
Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 移植・再生医療 / 再生医学 / 臨床 / 骨移植 / 脊椎固定術 |
Research Abstract |
We have successfully developed novel "chelate-setting apatite cement" using hydroxyapatite particles surface-modified with inositol phosphate. As we have examined the biocompatibility of this apatite cement, it showed good cell differentiation, attachment and proliferation, and bone induction both In vitro and In vivo. Thus, this present study demonstrates that this apatite cement can be useful as a new bone substitute for bone grafting in the spine.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Establishment of a Real-Time, Quantitative, and Reproducible Mouse Model of Staphylococcus Osteomyelitis Using Bioluminescence Imaging2012
Author(s)
H. Funao, K. Ishii, S. Nagai, A. Sasaki, T. Hoshikawa, M. Aizawa, Y. Okada, K. Chiba, S. Koyasu, Y. Toyama and M. Matsumoto
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Journal Title
Infection and Immunity
Volume: 80
Pages: 733-741
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Peer Reviewed
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[Presentation] IN VIVO EVALUATION OF CHELATE-SETTING CALCIUM-PHOSPHATE CEMENTS WITH VARIOUS BIORESORBABILITY USING RABBIT MODEL2010
Author(s)
T.KONISHI, S.TAKAHASHI, M.MIZUMOTO, S.SATO, M.HONDA, K.KIDA, Y.HORIGUCHI, K.ORIBE, H.MORISUE, Y.TOYAMA, M.MATSUMOTO, M.AIZAWA
Organizer
THE 3RD INTERNATIONAL CONGRESS ON CERAMICS
Place of Presentation
Osaka
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