| Project/Area Number |
21591906
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOYONE Tomoaki 帝京大学, 医学部, 教授 (10407918)
OOTORI Seiji 千葉大学, 医学部付属病院, 助教 (40361430)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 難治性疼痛 / 内因性オピオイド / 体外衝撃波 / 遺伝子導入 / 神経障害性疼痛 / 椎間板性腰痛 / proopiomelanocortin / 炎症性疼痛 / 神経因性疼痛 / 癌性疼痛 / プロピオメラノコルチン / 神経因性疼痛モデル / βエンドルフィン / POMC |
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| Research Abstract |
This study investigated the effects of POMC(proopiomelanocortin, the precursor forβ-endorphin, an endogenous opioid) gene transfection using radial shock waves(RSWs). We used three models ; inflammatory pain model, neuropathic pain model, and discogenic low back pain model. POMC gene transfection suppressed CGRP expression in the DRGs, microglial activation in the dorsal horn of the spinal cord, and pain behavior These findings suggest the effectiveness of POMC gene transfection using RSWs for the treatment of inflammatory pain, neuropathic pain, and discogenic low back pain, without side effects for a long time.
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