Magnetic targeting therapy with new bisphosphonates for the treatment of bone metastasis

• Project/Area Number: 21591916
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hiroshima University
• Principal Investigator: KUBO Tadahiko 広島大学, 病院, 講師 (70397959)
• Co-Investigator(Kenkyū-buntansha): OCHI Mitsuo 広島大学, 大学院・医歯薬学総合研究科, 教授 (70177244) ; SHIMOSE Shouji 広島大学, 大学院・医歯薬学総合研究科, 准教授 (30304439) ; MATSUO Toshihiro 独立行政法人国立病院機構(呉医療センター臨床研究部), その他部局等, 医師 (90397977)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌 / 転移性骨腫瘍 / ビスフォスフォネート

Research Abstract

Bisphosphonates, widely used to treat a variety of bone resorption diseases, reportedly have some antitumor effects. In this study, we developed novel bisphosphonates for cancer immunotherapy for bone metastasis and, more, Vanadium/ bisphosphonate complex for the treatment of malignant bone tumors.

Research Products

• [Journal Article] Minodronate for the treatment of osteoporosis (2010)
  • Author(s): Kubo T, Shimose S, Matsuo T, FujimoriJ, Ochi M.
  • Journal Title: Drugs Today(Barc) Volume: 46(1) Pages: 33-7
  • Peer Reviewed
• [Journal Article] Minodronate for the treatment of osteoporosis. (2010)
  • Author(s): Kubo Tadahiko
  • Journal Title: Drugs Today Volume: 46(1) Pages: 33-37
  • Peer Reviewed
• [Journal Article] Lipophilic bisphosphonates as dualfarnesyl/ geranylgeranyl diphosphate synthase inhibitors : an X-ray and NMRinvestigation (2009)
  • Author(s): Zhang Y, Cao R, Yin F, Hudock MP, GuoRT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, LeonA, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, KuboT, Ochi M, Mukkamala D, Oldfield E.
  • Journal Title: J Am Chem Soc Volume: 131(14) Pages: 5153-62
  • Peer Reviewed
• [Journal Article] Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors : an X-ray and NMR investigation (2009)
  • Author(s): Zhang Y
  • Journal Title: J Am Chem Soc. 131(14) Pages: 5153-5162
  • Peer Reviewed
• [Presentation] Cancer immunotherapy with novel bisphosphonates for bone metastasis (2012)
  • Author(s): Tadahiko Kubo, Shoji Shimose, Toshihiro Matsuo, Jun Fujimori, and Mitsuo Ochi
  • Organizer: 2012 annual meeting of american academy of orthopaedic surgeons
  • Place of Presentation: San Francisco, CA, USA
• [Presentation] Cancer immunotherapy with novel bisphosphonates for bone metastasis (2012)
  • Author(s): Tadahiko Kubo
  • Organizer: 2012 ANNUAL MEETING OF AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
  • Place of Presentation: Moscone Center, San Francisco, CA, USA
• [Presentation] 転移性骨腫瘍に対する新規ビスフォスフォネートの開発 (2011)
  • Author(s): 久保忠彦、下瀬省二、藤森淳、越智光夫
  • Organizer: 第44回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 京都府
• [Presentation] 転移性骨腫瘍に対する新規ビスフォスフォネートの開発 (2011)
  • Author(s): 久保忠彦
  • Organizer: 第44回日本整形外科学会骨・軟部腫瘍学術集会
  • Place of Presentation: 京都国際会議場(京都府)