Regenerative repair of bone defeots with osteoinduotive hydroxyapatite fabr icated to match the defect and implanted with combined use of computer-aided design, computer-aided manufaoturing, and computer-assisted surgery systems : a feasibility study in a canine model

• Project/Area Number: 21591922
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Osaka City University
• Principal Investigator: IWAKI Hiroyoshi 大阪市立大学, 大学院・医学研究科, 准教授 (20381981)
• Co-Investigator(Kenkyū-buntansha): MINODA MINODA Yukihide 大阪市立大学, 大学院・医学研究科, 講師 (90453133)
• Co-Investigator(Renkei-kenkyūsha): YANO Koichi 大阪労災病院, 整形外科
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
• Keywords: 骨形成蛋白(Bone morphogenetic protoin, BMP) / 巨大骨欠損 / 解剖学的再建 / Computer aided design / Computer Rided manufacturing / Computer navigation system / ヒーグル犬 / 解剖学的な再建 / 骨形成タンパク / Computer aided manufacturing / ビーグル犬

Research Abstract

Currently, regenerative repair of large bone detect is a challenging issue. The aim of this study was to achieve repair of large bone defects to the original three-dimensional(3D) anatomical state. An imaginary spherical malignant bone tumor of was placed in the left ilium of a canine on the 3D imaue. Resection of the whole tumor was planned preoperatively by using computer-aided design software. An image of the implant to fill the resulting bone defect was constructed on the computer image. A porous hydroxyapatite implant identical to the imaged bone defect was made with a computer-aided manufacturing system. To resect the iliac bone as planned preoperatively on the 3^CT image, computer-aided surgery was performed. The defect was filled with the fabricated implant and coated with a putty carrier with BMP-2.New bone formation was noted around each implant on CT images and remodeled to restore the original anatomy of the ilium on serial CT images. This new method may enable efficacious and precise regenerative repair of large bone defect without bone grafting.

Research Products

• [Journal Article] Conventional or navigated total knee arthroplasty affects sagittal component alignment. (2012)
  • Author(s): Sugama R, Minoda Y, Kobayashi A, Iwaki H, Ikebuchi M, Takaoka K, Nakamura H.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc.
  • Peer Reviewed
• [Journal Article] Early biological fixation of porous implant coated with paste-retaining recombinant bone ITIOrphogenetic protein (2012)
  • Author(s): Fukunaga K, Minoda Y, Iwakiri K, Iwaki H. Nakamura H, Takaoka K.
  • Journal Title: J Anhroplasty. Volume: 27(1) Pages: 143-149
  • Peer Reviewed
• [Journal Article] Regenerative Repair of Bone Defect with Osteoinductive Hydroxyapatite Fabricated to Match the Defect and Implanted with Combined Use of Computer-aided Design, Computer-aided Manufacturing, and Computer-assisted Surgery Systems : A Feasibility Study in a Canine Model (2012)
  • Author(s): Koichi Yano, Takashi Namikawa, Takuya Uemura, Masatoshi Hoshino, Shigeyuki Wakitani, Kunio Takaoka, Hiroaki Nakamura
  • Journal Title: Journal of Orthopaedic Science Volume: 17(In press) Issue: 4 Pages: 484-489
  • DOI: 10.1007/s00776-012-0235-7
  • Peer Reviewed
• [Journal Article] Mid-term clinical results of alumina medial pivot total knee arthroplasty. (2011)
  • Author(s): Iida T, Minoda Y, Kadoya Y, Matsui Y, Kobayashi A, Iwaki H, Ikebuchi M, Yoshida T. Nakamura H.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc
  • Peer Reviewed
• [Journal Article] Saeittal alignment of the lower extremity while standing in female. (2011)
  • Author(s): Sugarna R, Minoda Y. Kobayashi A, Iwaki H, Ikebuchi M, Hashimoto Y, Takaoka K, Nakamura H.
  • Journal Title: Knee Surg Sports T raumatol Arthrosc. Volume: 19(1) Pages: 74-9
  • Peer Reviewed
• [Journal Article] Analysis of sex and race and the size and shape of the distal femur using virtual surgery and archived computed tomography images. Analysis of sex and race and the size and shape of the distal femur using virtual surgery and archived computed tomography images. (2010)
  • Author(s): Banies CL, Iwaki H, Minoda Y, Green JM 2nd, Obert RM.
  • Journal Title: J Surg Orthop Adv. Volume: 19(4) Pages: 200-8
  • Peer Reviewed
• [Journal Article] Comparison of bone mineral density between porous tantalum and cemented tibial total knee arthroplasty components. (2010)
  • Author(s): Minoda Y, Kobayashi A, Iwaki Ikebuchi M, Inori F, Takaoka K.
  • Journal Title: J Bone Joint Surg Am. Volume: 92(3) Pages: 700-6
  • Peer Reviewed
• [Journal Article] The risk of notching the anterior femoral cortex with the use of navigation systems in total knee arthroplasty. (2010)
  • Author(s): Minoda Y, Kobayashi A, Mitsuhiko Kadoya Y, Ohashi H, Takaoka K, Nakamura H.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. Volume: 18(6) Pages: 718-22
  • Peer Reviewed
• [Journal Article] In vivo analysis of polyethylene wear particles after total knee arthroplasty : the influence of improved materials and designs. (2009)
  • Author(s): Minoda Y, Kobayashi A. Iwaki H, Iwakiri K, Inori F, Sugama R, Ikebuchi M, Kadoya Y, Takaoka K.
  • Journal Title: J Bone Joint Sung Am. Volume: 91Suppl6 Pages: 67-73
  • Peer Reviewed
• [Journal Article] In vivo comparison of wear particles between highly crosslinked polyethylene and conventional polyethylene in the same design of total knee arthroplasties. (2009)
  • Author(s): Iwakiri K, Minoda Y, Kobayashi A, Sugama R. Iwaki Inori F, Hashimoto Y, Ohashi H, Ohta Y. Fukunaga K, Takaoka K
  • Journal Title: J Biomed Mater Re s B Appl Biomater. Volume: 91(2) Pages: 799-804
  • Peer Reviewed
• [Journal Article] TKA sagittal alignment with navigation systems and conventional techniques vary only a few degrees. (2009)
  • Author(s): Minoda Y, Kobayashi A, Iwaki H, Ohashi H, Takaoka K.
  • Journal Title: Clin Orthop Relat Res. Volume: 467(4) Pages: 1000-6
  • Peer Reviewed
• [Journal Article] Effect of simvastatin on steroid-induced osteonecrosis evidenced by the serum lipid level and hepatic cytochrome P4503A in a rabbit model (2008)
  • Author(s): Iwakiri K, Oda Y, Kaneshiro Y, Iwaki H, Masada T, Kobayashi A, Asada A, Takaoka K.
  • Journal Title: J Orthop Sci. Volume: 13(5) Pages: 463-8
  • NAID: 10024301755
  • Peer Reviewed
• [Journal Article] Alumina inlay failure in cemented polyethylene-backed total hip arthroplasty. (2008)
  • Author(s): Iwakiri K, Iwaki H, Minoda Y, Ohashi H, Takaoka K.
  • Journal Title: Clin Orthop Relat Res. Volume: 466(5) Pages: 1186-92
  • Peer Reviewed
• [Journal Article] Sagittal alignment of the lower extremity while standing in Japanese male. (2008)
  • Author(s): Minoda Y, Kobayashi A, Iwaki H, Sugama R. Iwakiri K, Kadoya Y, Ohashi H, Takaoka K.
  • Journal Title: Arch Orthop Trauma Surg. Volume: 128(4) Pages: 435-42
  • Peer Reviewed
• [Journal Article] Characteristics of Hylamer polyethylene particles isolated from peri-prosthetic tissues of failed cemented total hip arthroplasties. (2008)
  • Author(s): Iwakiri K, Iwaki H, Kobayashi A, Minoda Y. Kagiyama H, Kadoya Y, Takaoka K.
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: 85(1) Pages: 125-9
  • Peer Reviewed
• [Journal Article] Increased hepatic cytochrome P4503A activity decreases the risk of developing steroid-induced osteonecrosis in a rabbit model. (2008)
  • Author(s): Masada T, K, Oda Y, Kaneshiro Y, Iwaki H, Ohashi H, Takaoka K.
  • Journal Title: J Orthop Res. Volume: 26(1) Pages: 91-5
  • Peer Reviewed
• [Journal Article] Low hepatic cytochrome P450 3A activity is a risk for corticosteroid-induced osteonecrosis. (2006)
  • Author(s): Kaneshiro Y, Oda Y, Iwakiri K, Masada T, Iwaki H, Hirota Y, Kondo K, Takaoka K.
  • Journal Title: Clin Pharmacol Thor Volume: 80(4) Pages: 396-402
  • Peer Reviewed
• [Journal Article] Polyethylene wear particle generation in vivo in an alumina medial pivot total knee prosthesis. (2005)
  • Author(s): Minoda Y, Kobayashi A, Iwaki H, Miyaguchi M, Kadoya Y, Ohashi H, Takaoka K.
  • Journal Title: Biomaterials Volume: 26(30) Pages: 6034-40
  • Peer Reviewed
• [Journal Article] Characteristics of polyethylene wear particles isolated from synoviai fluid after mobile-bearing and posterior-stabilized total knee arthroolasties. (2004)
  • Author(s): Minoda Y, Kobayashi A, Iwaki H, Miyaguchi M, Kadoya Y, Ohashi H, Takaoka K.
  • Journal Title: J Biomed Mater Res B Appl Biornater. Volume: 71(1) Pages: 1-6
  • Peer Reviewed
• [Journal Article] Polyethylene wear particles in synovial fluid after total knee arthroplasty. (2003)
  • Author(s): Minoda Y, Kobayashi A, Iwaki H, Miyaguchi M, Kadoya Y, Ohashi H, Yamano Y, Takaoka K.
  • Journal Title: Clin Orthop Relat Res. Volume: 410 Pages: 165-72
  • Peer Reviewed
• [Journal Article] Human monocyte response to retrieved polymethylmethacrylate particles (2002)
  • Author(s): Miyaguc hi M, Kobayashi A, Iwaki H, Ohashi H Kadoya Y, Yamano Y.
  • Journal Title: J Biomed Mater Res. Volume: 62(3) Pages: 331-7
  • Peer Reviewed
• [Presentation] Intra-Operative Assessment Of Mid-Flexion Instability In Total Knee Arthropalsty (2012)
  • Author(s): Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugama R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H.
  • Organizer: Annual meeting of Orthopaedic Reserch Society(ORS)
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2012-02-04
• [Presentation] The Extension Gap Becomes Tight and Valgus After Implantation of Mobile-bearing Total Knee Prosthesis (2012)
  • Author(s): Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugarna R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Reserch Society(ORS)
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2012-02-04
• [Presentation] OAnnual meeting of Orthopaedic Reserch Society(ORS) perative Technique Affected The Intra-operative Joint Kinematics Of Total Knee Arhtroplasty (2012)
  • Author(s): Minoda Y, Nakagawa S, Kadoya Y, Kobayashi A, Tomari H, Kondo M, Iwaki H, Ikebuchi M, Yoshida T, Matsui Y, Sumitomo A, Sugama R, Mizokawa S, Higuma Y, Noguchi T, Hirakawa H, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Reserch Society(ORS)
  • Place of Presentation: San Francisco, CA. USA.
  • Year and Date: 2012-02-04
• [Presentation] In Viva Wear Particles of Annealed Highly Cross-Linked Polyethylene in Total Hip Arthropalsty (2012)
  • Author(s): Minoda, Y, Hata K, Iwaki H, Ikebuchi M, Yoshida T, Miyazaki N, Miyake Y, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Reserch Society(ORS)
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2012-02-04
• [Presentation] In Vivo Wear Particles of Annealed Highly Cross-Linked Polyethylene in Total Hip Arthropalsty (2012)
  • Author(s): Hata K, Minoda Y, Iwaki H, lkebuchi M, Yoshida T, Miyazaki N, Miyake Y, Nakamura H
  • Organizer: Annual meeting of Orthopaedic Reserch Society(ORS)
  • Place of Presentation: San Francisco, CA, USA
  • Year and Date: 2012-02-04
• [Presentation] Invited Iecture ; Future expectation of TKA (2011)
  • Author(s): Minoda Y, Kadova Y, Kobayashi A, Iwaki H, Iwakiri K, Iida T, Matusi Y, Ikebuchi M, Yoshida T, Nakamura H
  • Organizer: 24^<th> Annual meeting of the International Society for Technology in Arthroplasty
  • Place of Presentation: Brues, Belgium
  • Year and Date: 2011-09-20
• [Presentation] BMD Change Under Bisphosphonate Therapy-Comparison Between Mobile and Fixed Bearing TKA Prostheses- (2011)
  • Author(s): Minoda Y, Iwaki H, Ikebuchi M, Yoshida T, Nakamura H
  • Organizer: 24^<th> Annual meeting of the International Society for Technology in Arthroplasty
  • Place of Presentation: Brues, Belgium
  • Year and Date: 2011-09-20
• [Presentation] High incidence of anterior femoral cortex notching using navigation system in TKA (2011)
  • Author(s): Minoda Y, Watanabe K, Iwaki H, Ikebuchi M, Yoshida T, Iida T, Ikawa T, Hashimoto Y, Nakamura H
  • Organizer: Annual meeting of American Association of Orthopaedic Surgeons
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-02-15
• [Presentation] (2011)
  • Author(s): M inoda Y, Watanabe K, Iwaki H, Ikebuchi M, Yoshida T, Iida T, Ikawa T, Hashimoto Y, Nakamura H
  • Organizer: Annual meeting of American Academy of Orthopaedic Surgeons(AAOS)
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2011-02-07
• [Presentation] Comparison of BMD around the Knee between Trabecular Metal and Cemented Tibial Component ; Four-year Follow-Up Study (2011)
  • Author(s): Minoda Y, Kobayashi A, Ikebuchi M, Iwaki H, Inori F, Hashimoto Y, Yoshida T, Iida T, Ikawa T, Yamasaki S, Nakamura H
  • Organizer: Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: Long Beach, CA, USA
  • Year and Date: 2011-01-13
• [Presentation] Flexion Gap Preparation Opens Both the Extension and Flexion Gap during Total Knee Arthroplasty (2011)
  • Author(s): Minoda Y, Iwaki H, Ikebuchi M, Yoshida T, Iida T, Ikawa T, Yamasaki S, Hirokai N
  • Organizer: Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: Long Beach, CA, USA
  • Year and Date: 2011-01-13
• [Presentation] A Cemented Mobile-Bearing Total Knee Arthroplasty Prevents Periprosthetic Loss of Bone Mineral Density around the Femoral Component : Four-year Follow-Up Study (2011)
  • Author(s): Minoda Y, Kobayashi A, Ikebuchi M, Iwaki H, Inori F, Hashimoto Y, Yoshida T, Iida T, Ikawa T. Yamasaki S, Nakamura H
  • Organizer: Annual Meeting of Orthopaedic Research Society
  • Place of Presentation: Long Beach. CA. USA
  • Year and Date: 2011-01-13
• [Presentation] Regenerative repair of bone defect with osteoinductive hydroxyapatite (2011)
  • Author(s): Koichi Yano
  • Organizer: 57^<th> Annual Meeting of the Orthopaedic research Society
  • Place of Presentation: Long beach、CA、USA
  • Year and Date: 2011-01-13
• [Presentation] Regenerative repair of bone defect with osteoinductive hydroxyapatite fabricated to match the defect and implanted with combined use of computer-aided design, computer-aided manufacturing, and computer-assisted surgery systems-A feasibility study in a canine model- (2011)
  • Author(s): Koichi Yano, et al
  • Organizer: 57^<th> Annual Meeting of the Orthopaedic research Society
  • Place of Presentation: Long beach, CA, USA
• [Presentation] BMPによる骨再生の新たな手法開発への取り組み (2009)
  • Author(s): 矢野公一
  • Organizer: 日本手の外科学会学術集会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2009-04-16