Abnormal DNA double-strand break repair in human malignant soft tissue tumors
Project/Area Number |
21591926
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | 独立行政法人国立病院機構九州がんセンター臨床研究センター (2011) Department of Clinical Research, National Hospital Organization National Kyushu Cancer Center (2009-2010) |
Principal Investigator |
TANAKA Kazuhiro 独立行政法人国立病院機構九州がんセンター臨床研究センター, 臨床研究センター (10274458)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 骨・軟部腫瘍学 / 発がん / 染色体転座 / DNA二本鎖切断修復 / 癌 / 骨軟部腫瘍 / DNA修復 |
Research Abstract |
Chromosomal translocations to generate chimaeric fusion genes are a hallmark of a group of soft tissue sarcomas. Whereas the pathogenic significance of these anomalous genes has been generally established in tumours of this category, the origin of gene fusion still remains unknown. Using DNA microarrays, we observed expression of the genes participating in the DNA double-strand break repair pathways. In two cell lines established from human Ewing's sarcomas, their expression was uniformly elevated. Aberrant expression of double-strand break repair genes may be generally associated with tumourigenesis by the chimaeric fusion genes.
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Report
(4 results)
Research Products
(16 results)
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[Presentation] 軟部肉腫の治療2009
Author(s)
田仲和宏
Organizer
第23回日本整形外科学会基礎学術集会
Place of Presentation
横浜
Year and Date
2009-11-05
Related Report
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[Presentation] 骨肉腫治療の未来2009
Author(s)
田仲和宏、岩本幸英
Organizer
第82回日本整形外科学会学術総会
Place of Presentation
福岡
Year and Date
2009-05-14
Related Report
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