Preclinical trial of less invasive synovial stem cell therapy using a pig knee articular cartilage defect model
Project/Area Number |
21591937
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
MUNETA Takeshi 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50190864)
|
Co-Investigator(Kenkyū-buntansha) |
SEKIYA Ichiro 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10345291)
KOBAYASHI Eiji 自治医科大学, 医学部, 教授 (00245044)
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Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | H :運動器外傷学 / 幹細胞治療 / 滑膜幹細胞 / 軟骨欠損 / 大動物研究 / 低侵襲手術 / 大型動物実験 / ミニブタ / 関節軟骨損傷 / 滑膜由来幹細胞 / 細胞治療 |
Research Abstract |
Less invasive synovial stem cell transplantation promoted healing of a full-thickness articular cartilage defect at weight-bearing area in a mini pig model. The results facilitate to perform clinical trial of the transplantation on human patients with articular cartilage injury.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Arthroscopic, histological and MRIanalyses of cartilage repair after aminimally invasive method oftransplantation of allogeneic synovialmesenchymal stromal cells into cartilagedefects in pigs2012
Author(s)
Nakamura T, Sekiya I, Muneta T, Hatsushika D, Horie M, Tsuji K, Kawarasaki T, Watanabe A, Hishikawa S, Fujimoto Y, Tanaka H, Kobayashi E
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Journal Title
Cytotherapy
Volume: 14
Pages: 327-338
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[Journal Article] Atelocollagen-associated autologous chondrocyte implantation for the repair of chondral defects of the knee : a prospective multicenter clinical trial in Japan.2009
Author(s)
Tohyama H, Yasuda K, Minami A, Majima T, Iwasaki N, Muneta T, Sekiya I, Yagishita K, Takahashi S, Kurokouchi K, Uchio Y, Iwasa J, Deie M, Adachi N, Sugawara K, Ochi M.
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Journal Title
J Orthop Sci. 14(5)
Pages: 579-588
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Peer Reviewed
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[Journal Article] Mesenchymal stem cells derived from synovium, meniscus, anterior cruciate ligament, and articular chondrocytes share similar gene expression profiles.2009
Author(s)
Segawa Y, Muneta T, Makino H, Nimura A, Mochizuki T, Ju YJ, Ezura Y, Umezawa A, Sekiya I.
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Journal Title
J Orthop Res. 27(4)
Pages: 435-441
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
宗田大, 秋田恵一
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Journal Title
「手術進入法-下肢」最新整形外科学大系8 中山書店(第5章膝関節への進入法内側側方進入法)
Pages: 212-217
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[Journal Article]2009
Author(s)
宗田大
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Journal Title
Monthly Book Orthopaedics(前十字靭帯損傷の診断と治療。すぐに役立つ日常整形外科診療に対する私の工夫)
Pages: 231-242
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[Presentation] Synovial Mesenchymal Stem Cells Transplantation Contributes to Cartilage Regeneration in Porcine Model2011
Author(s)
Nakamura T, Sekiya I, Hatsushika D, Horie M, Tsuji K, Muneta T, Kawarasaki T, Watanabe A, Hishikawa S, Fujimoto Y, Tanaka H, Kobayashi E.
Organizer
Orthopaedic ResearchSociety 2011
Place of Presentation
Long Beach
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