| Project/Area Number |
21591943
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
|
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| Research Institution | Osaka University |
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Principal Investigator |
|
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Hiroyuki 大阪大学, 大学院・医学系研究科, 助教 (00432542)
|
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| Project Period (FY) |
2009 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 骨芽細胞分化 / Netrin / Unc5 / 神経組織 / Schwannoma / Noggin / Mek5-Erk5 / Schwann細胞 / MEK5-Eｒｋ５ / noggin / Src kinase / MAPK |
|---|
| Research Abstract |
In order to explore new relations between neurological tissue and skeletal tissue, we investigated functions of Netrin-1, which is one of neural axon extension molecules, on osteoblasts. Moreover, we searched out a bone-formation inhibitory protein secreted by neuronal tumor. We demonstrated that Netrin-1 have inhibitory effects of osteoblastic differentiation without proliferative suppression. In addition, we identified one of bone-formation inhibitory factors, Noggin, secreted by neuronal tissues. On the other hand, MEK5-Erk5 signal transduction pathway exists in osteoblasts and it suppresses osteoblastic differentiation.
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