Identification of osteoblast function regulating factor secreted by human mesenchymal stem cell
| Project/Area Number |
21591945
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
SASAKI Junzo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30093686)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Toshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40294459)
FUJITA Hirofumi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20423288)
MIKI Yukari 香川県立保健医療大学, 保健医療学部, 助教 (70397876)
MORIMOTO Yuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00452574)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 間葉系幹細胞 / 骨芽細胞分化 / 死細胞 |
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| Research Abstract |
We investigated whether cell death is induced during the calcification process by osteoblast derived from human bone marrow mesenchymal stem cells in vitro, and whether dead cells are involved in the calcification process. Our findings showed that cell death was induced in osteogenic culture of mesenchymal stem cells in vitro, and suggested that caspase-independent dead cells and/or necrotic dead cells of osteoblast lineage might be involved in the mechanism of bone calcification.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells2011
Author(s)
Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, Utsumi K.
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Journal Title
Mol Cell Biochem.
Volume: 358(1-2)
Pages: 297-307
Related Report
Peer Reviewed
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[Journal Article] Effect of risedronate on osteoblast differentiation, expression of receptor activator of NF-κB ligand and apoptosis in mesenchymal stem cells2011
Author(s)
Fujita H, Kurokawa K, Ogino T, Ono M, Yamamoto M, Oka T, Nakanishi T, Kobayashi N, Tanaka N, Ogawa T, Suzaki E, Utsumi K, Sasaki J.
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Journal Title
Basic Clin Pharmacol Toxicol.
Volume: 109(2)
Issue: 2
Pages: 78-84
DOI
Related Report
Peer Reviewed
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[Journal Article] Serum-dependent export of protoporphyrin IX by ATP-binding cassette transporter G2 in T24 cells2011
Author(s)
Ogino T, Kobuchi H, Munetomo K, Fujita H, Yamamoto M, Utsumi T, Inoue K, Shuin T, Sasaki J, Inoue M, Utsumi K
-
Journal Title
Mol Cell Biochem
Volume: 358
Pages: 297-307
Related Report
Peer Reviewed
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