The pathogenesis of joint destruction based on osteoporosis

• Project/Area Number: 21591948
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: YAMAMOTO Takuaki 九州大学, 病院, 講師 (20336035)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 骨粗鬆症 / 脆弱性骨折 / 関節破壊 / 骨壊死 / 大腿骨頭軟骨下脆弱性骨折 / MRI / 骨折線 / 骨切り術 / 病理像

Research Abstract

The aim of this study is to identify the risk factors associated with the prognosis of SIF. The band length in patients with progression of collapse(mean : 20. 5 mm) was significantly larger than in patients without a progression of collapse(mean : 13. 2 mm). The band length ratio in patients with progression of collapse(mean : 57. 7%) was also significantly higher than in patients without a progression of collapse(mean : 38. 2%). The cutoff points of band length and band length ratio were 20. 2 mm and 57. 9% respectively. These results indicate that the band length and the band length ratio might be predictive for the progression of collapse in SIF.

Research Products

• [Journal Article] Prognostic factors associated with a subchondral insufficiency fracture of the femoral head (2012)
  • Author(s): Iwasaki K, Yamamoto T, Motomura G, Ikemura S, Nakashima Y, Mawatari T, Iwamoto Y
  • Journal Title: Br J Radiol Volume: 85 Pages: 214-218
• [Journal Article] Effects of an antiplatelet drug on the prevention of steroid-induced osteonecrosis in rabbits (2012)
  • Author(s): Yamaguchi R, Yamamoto T, Motomura G, Ikemura S, Iwasaki K, Zhao G, Iwamoto Y
  • Journal Title: Rheumatology
• [Journal Article] Prognostic Factors Associated with a Subchondral Insufficiency Fracture of the Femoral Head (2012)
  • Author(s): Iwasaki K., et.al.
  • Journal Title: British Journal of Radiology Volume: 85 Issue: 1011 Pages: 214-218
  • DOI: 10.1259/bjr/44936440
  • Peer Reviewed
• [Journal Article] Morphological analysis of collapsed regions in osteonecrosis of the femoral head (2011)
  • Author(s): Motomura G, Yamamoto T, Yamaguchi R, Ikemura S, Nakashima Y, Mawatari T, Iwamoto Y
  • Journal Title: J Bone Joint Surg Volume: 93B Pages: 184-187
• [Journal Article] Incidence of non-traumatic osteonecrosis of the femoral head in the Japanese population (2011)
  • Author(s): Yamaguchi R, Yamamoto T, Motomura G, Ikemura S, Iwamoto Y
  • Journal Title: Arthritis Rheum Volume: 63 Pages: 3169-3173
• [Journal Article] Lipid metabolism abnormalities in alcohol-treated rabbits : a morphometric and haematologic study comparing high and low alcohol doses (2011)
  • Author(s): Ikemura S, Yamamoto T, Motomura G, Iwasaki K, Yamaguchi R, Zhao G, Iwamoto Y
  • Journal Title: Int J Exp Path Volume: 92 Pages: 290-295
• [Journal Article] Subchondral insufficiency fracture of the femoral head in young adults (2011)
  • Author(s): Iwasaki K, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y
  • Journal Title: Clinical Imaging Volume: 35 Pages: 208-213
• [Journal Article] Incidence of non-traumatic osteonecrosis of the femoralhead in the Japanese population (2011)
  • Author(s): Yamaguchi R, Yamamoto T, et al
  • Journal Title: Arthritis and Rheumatism Volume: 63 Issue: 10 Pages: 3169-73
  • DOI: 10.1002/art.30484
  • Peer Reviewed
• [Journal Article] Morphological analysis of collapsed lesions in osteonecrosis of the femoral head (2011)
  • Author(s): Motomura G, Yamamoto T, et al
  • Journal Title: J Bone and Joint Surgery Volume: 93B Pages: 184-7
  • Peer Reviewed
• [Journal Article] Transtrochanteric rotational osteotomy for a subchondral insufficiency fracture of the femoral head in young adults (2010)
  • Author(s): Yamamoto T, Iwasaki K, Iwamoto Y
  • Journal Title: Clin Orthop Relat Res Volume: 468 Pages: 3181-3185
  • NAID: 10027678717
• [Journal Article] The repair process of osteonecrosis after a transtrochanteric rotational osteotomy (2010)
  • Author(s): Yamamoto T, Ikemura S, Iwamoto Y, Sugioka Y
  • Journal Title: Clin Orthop Relat Res Volume: 468 Pages: 3186-3191
• [Journal Article] MRI evaluation of collapsed femoral heads in patients 60 years old or older : Differentiation of subchondral insufficiency fracture from osteonecrosis of the femoral head (2010)
  • Author(s): Ikemura S, Yamamoto T, Motomura G, Nakashima Y, Mawatari T, Iwamoto Y
  • Journal Title: Am J Roentgenol Volume: 195 Pages: 63-68
• [Journal Article] Long-term outcome of transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head in patients with Systemic Lupus Erythematosus (2010)
  • Author(s): Motomura G, Yamamoto T, Suenaga K, Nakashima Y, Mawatari T, Ikemura S, Iwamoto Y
  • Journal Title: Lupus Volume: 19 Pages: 860-865
• [Journal Article] Transtrochanteric rotational osteotomy for a subchondral insufficiency fracture of the femoral head in young adults. (2010)
  • Author(s): Yamamoto T, et al.
  • Journal Title: Clinical Orthopaedics and Related Research Volume: 468 Pages: 3181-3185
  • NAID: 10027678717
  • Peer Reviewed
• [Journal Article] The repair process of osteonecrosis after a transtrochanteric rotational osteotomy (2010)
  • Author(s): Yamamoto T, et al.
  • Journal Title: Clinical Orthopaedics and Related Research Volume: 468 Pages: 3186-3191
  • Peer Reviewed
• [Journal Article] MRI evaluation of collapsed femoral heads in patients 60 years old or older : Differentiation of subchondral insufficiency fracture from ON of femoral head. (2010)
  • Author(s): Ikemura S, Yamamoto T, et al.
  • Journal Title: AJR Volume: 195 Pages: 63-68
  • Peer Reviewed
• [Journal Article] Subchondral insufficiency fracture of the femoral head after liver transplantation (2009)
  • Author(s): Iwasaki, Yamamoto, et al.
  • Journal Title: Skeletal Radiology 38 Pages: 925-928
  • Peer Reviewed
• [Journal Article] Transtrochanteric anterior rotational osteotomy for osteonecrosis of the femoral head in patients 20 years of age or younger (2009)
  • Author(s): Ikemura, Yamamoto, et al.
  • Journal Title: J Pediatric Orthopaedics 29 Pages: 219-223
  • Peer Reviewed
• [Journal Article] Intraarticular findings in symptomatic developmental dysplasia of the hip (2009)
  • Author(s): Fujii, Nakashima, Jingushi, Yamamoto, et al.
  • Journal Title: J Pediatric Orthopaedics 29 Pages: 9-13
  • Peer Reviewed
• [Presentation] 軟骨下脆弱性骨折 (2011)
  • Author(s): 山本卓明
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州(招待講演)
  • Year and Date: 2011-09-29
• [Presentation] Defect of the quadratus femoris muscle in transtrochanteric rotational osteotomy for osteonecrosis (2011)
  • Author(s): Takuaki Yamamoto
  • Organizer: International Hip Society
  • Place of Presentation: Czech, Prague(招待講演)
  • Year and Date: 2011-09-07
• [Presentation] Osteonecrosis and subchondral insufficiency fracture (2011)
  • Author(s): Takuaki Yamamoto
  • Organizer: The 55th Korean Hip Society Meeting
  • Place of Presentation: Korea, Seoul(招待講演)
  • Year and Date: 2011-05-19
• [Presentation] 骨壊死と軟骨下脆弱性骨折-基本的病態と鑑別点 (2011)
  • Author(s): 山本卓明
  • Organizer: 第116回中部日本整形外科災害外科学会
  • Place of Presentation: 高知(招待講演)
  • Year and Date: 2011-04-07
• [Presentation] Osteonecrosis and subchondral insufficiency fracture (2011)
  • Author(s): Yamamoto T
  • Organizer: The 55th Korean Hip Society Meeting
  • Place of Presentation: Seoul, Korea
• [Presentation] Defect of the quadratus femoris muscle in transtrochanteric rotationa l osteotomy for osteonecrosis (2011)
  • Author(s): Yamamoto T, Iwamoto Y
  • Organizer: International Hip Society Closed
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 骨壊死と軟骨下脆弱性骨折-基本的病態と鑑別点 (2011)
  • Author(s): 山本卓明
  • Organizer: 第116回中部日本整形外科災害外科学会・学術集会
  • Place of Presentation: 高知
• [Presentation] 軟骨下脆弱性骨折 (2011)
  • Author(s): 山本卓明、岩本幸英
  • Organizer: 第39回日本磁気共鳴医学会大会
  • Place of Presentation: 北九州
• [Presentation] 手術の不成功要因-大腿骨頭前方回転骨切り術 (2011)
  • Author(s): 山本卓明、岩本幸英
  • Organizer: 第38回日本股関節学会学術集会
  • Place of Presentation: 鹿児島
• [Presentation] 大腿骨頭前方回転骨切り術の成績不良例因子の検証 (2011)
  • Author(s): 山本卓明、岩本幸英
  • Organizer: 第38回日本股関節学会学術集会
  • Place of Presentation: 鹿児島
• [Presentation] 関節内脆弱性骨折の画像診断 (2011)
  • Author(s): 山本卓明、岩本幸英
  • Organizer: 第13回日本骨粗鬆症学会
  • Place of Presentation: 神戸
• [Presentation] 大腿骨頭回転骨切り術の術後成績 (2010)
  • Author(s): 山本卓明
  • Organizer: 第120回西日本整形災害外科学会
  • Place of Presentation: 佐賀市文化会館(佐賀県)
  • Year and Date: 2010-11-14
• [Presentation] Imaging of osteonecrosis and bone marrow edema (2009)
  • Author(s): Takuaki Yamamoto
  • Organizer: International Skeletal Society
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2009-09-05
• [Book] 今日の治療指針私はこう治療している (2011)
  • Author(s): 山本卓明
  • Publisher: 医学書院
• [Book] 整形外科病態生理 (2011)
  • Author(s): 山本卓明、岩本幸英
  • Publisher: MCメディカ出版
• [Book] 整形外科手術の要点と盲点 (2011)
  • Author(s): 山本卓明
  • Publisher: 文光堂
• [Book] 股関節の痛み (2011)
  • Author(s): 山本卓明
  • Publisher: 南江堂
• [Book] 骨軟部の画像診断 (2011)
  • Author(s): 山本卓明、小田義直
  • Publisher: ベクトルコア
• [Book] 骨軟部の画像診断-大腿骨頭軟骨下脆弱性骨折 (2011)
  • Author(s): 山本卓明
  • Total Pages: 223
  • Publisher: ベクトルコア
• [Book] 大腿骨頭軟骨下脆弱性骨折 別冊整形外科57 (2010)
  • Author(s): 岩崎賢優、山本卓明, 他
  • Total Pages: 239
  • Publisher: 南江堂
• [Book] 別冊整形外科 関節周辺骨折 大腿骨頭軟骨下脆弱性骨折の診断と治療 (2009)
  • Author(s): 山本卓明, 岩本幸英
  • Total Pages: 239
  • Publisher: 南江堂