The anti-inflammatory effects of stat in on osteoarthritis
| Project/Area Number |
21591949
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 変形性関節症 / 関節軟骨 / スタチン / 高脂血症薬 |
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| Research Abstract |
Thirty-two mature rabbits that underwent bilateral anterior cruciate ligament transaction(ACLT) received six consecutive weekly intra-articular injections of mevastatin. The knee joints were assessed by morphological, histological and biochemical methods.
Intra-articular injection of mevastatin significantly reduced cartilage degradation, as assessed by morphological and histological examinations. During the development of experimental OA, intra-articular administration of statin reduces cartilage degradation.
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Report
(4 results)
Research Products
(19 results)
