The anti-inflammatory effects of stat in on osteoarthritis

• Project/Area Number: 21591949
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Kyushu University
• Principal Investigator: MATSUDA Shuichi 九州大学, 医学研究院, 准教授 (40294938)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 変形性関節症 / 関節軟骨 / スタチン / 高脂血症薬

Research Abstract

Thirty-two mature rabbits that underwent bilateral anterior cruciate ligament transaction(ACLT) received six consecutive weekly intra-articular injections of mevastatin. The knee joints were assessed by morphological, histological and biochemical methods.
Intra-articular injection of mevastatin significantly reduced cartilage degradation, as assessed by morphological and histological examinations. During the development of experimental OA, intra-articular administration of statin reduces cartilage degradation.

Research Products

• [Journal Article] Age-related changes in kinematics of the knee joint during deep squat (2012)
  • Author(s): Fukagawa S, Leardini A, Callewart B, Wong PD, Desloovere K, Matsuda S, Bellemans J
  • Journal Title: The Knee Volume: (In press) Issue: 3 Pages: 236-243
  • DOI: 10.1016/s0966-6362(01)00191-6
  • Peer Reviewed
• [Journal Article] Articular cartilage of the posterior condyle can affect rotational alignment in total knee arthroplasty (2011)
  • Author(s): Tashiro Y, Uemura M, Matsuda S, Okazaki K, Kawahara S, Hashizume M, Iwamoto Y
  • Journal Title: Knee Surgery Sports Traumatology Arthroscopy Volume: (In press) Issue: 8 Pages: 1463-1469
  • DOI: 10.1007/s00167-011-1691-x
  • Peer Reviewed
• [Journal Article] Displacement of the Tibia Increases in Deep Flexion of the Knee Joint (2010)
  • Author(s): Fukagawa S, Matsuda S, Tashiro Y, Hashizume M, Iwamoto Y. Posterior
  • Journal Title: Crin Orthop Volume: 468 Pages: 1107-1114
  • Peer Reviewed
• [Journal Article] Posterior Displacement of the Tibia Increases in Deep Flexion of the Knee Joint. (2010)
  • Author(s): Fukagawa S, Matsuda S, et al
  • Journal Title: Clin Orthop Volume: 468 Pages: 1107-1114
  • Peer Reviewed
• [Journal Article] Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammatio (2009)
  • Author(s): Akasaki Y, Matsuda S, Nakayama K, Miura H, Fukagawa S, Iwamoto Y.
  • Journal Title: Osteoarthritis and Cartilage Volume: 17 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Mevastatin reduces cartilage degradation in rabbit experimental osteoarthritis through inhibition of synovial inflammation (2009)
  • Author(s): Akasaki Y, Matsuda S, et al
  • Journal Title: Osteoarthritis and Cartilage 17 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Agerelated changes in kinematics of the knee joint during deep squat
  • Author(s): Fukagawa S, Leardini A, Callewart B, Wong PD, Desloovere K, Matsuda S, Bellemans J.
  • Journal Title: The Knee Volume: (in press)
  • Peer Reviewed
• [Journal Article] Articular cartilage of the posterior condyle can affect rotational alignment in total knee arthroplasty
  • Author(s): Tashiro Y, Uemura M, Matsuda S, Okazaki K, Kawahra S, Hashizume M, Iwamoto Y.
  • Journal Title: Knee Surg Sports Traumatol Arthrosc. Ip L) Volume: (in press)
  • Peer Reviewed
• [Presentation] 変形性膝関節症における最近のトピックス (2012)
  • Author(s): 松田秀一
  • Organizer: 福岡労災保険指定病院協会学術講演会
  • Place of Presentation: 福岡市(招待講演)
  • Year and Date: 2012-05-24
• [Presentation] Inhibition of geranylgeranylation reduces MCP-l production in IL-lis-stimulated human synoviocytes (2012)
  • Author(s): Akasaki Y, Matsuda S, Kawahara S, Iwamoto Y.
  • Organizer: Orthopedic Research Society 2012
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] Inhibition of geranylgeranylation reduces MCP-1 production in IL-1β-stimulated human synoviocytes (2012)
  • Author(s): Y.Akasaki, S.Matsuda, S.Kawahara, Y.Iwamoto
  • Organizer: Orthopedic Research Society 2012
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2012-02-04
• [Presentation] 変形性膝関節症における最近のトピックス(招待講演) (2011)
  • Author(s): 松田秀一
  • Organizer: 福岡労災保険指定病院協会学術講i演会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-05-24
• [Presentation] ADRCを用いた骨軟骨再生(招待講演) (2011)
  • Author(s): 中山功一、松田秀一、他
  • Organizer: 第24回軟骨代謝学会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-03-05
• [Presentation] ADRCを用いた骨軟骨再生 (2011)
  • Author(s): 中山功一、松田秀一, 他
  • Organizer: 第24回軟骨代謝学会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-03-05
• [Presentation] ll-lβ刺激滑膜細胞において、スタチンはイソプレノイドの合成を阻害することでMCP-lとMMP-sの産生を抑制する (2011)
  • Author(s): 川原慎也、松田秀一、他
  • Organizer: 第24回軟骨代謝学会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-03-04
• [Presentation] Il-1β刺激滑膜細胞において、スタチンはイソプレノイドの合成を阻害することでMCP-1とMMP-3の産生を抑制する (2011)
  • Author(s): 川原慎也、松田秀一, 他
  • Organizer: 第24回軟骨代謝学会
  • Place of Presentation: 福岡市
  • Year and Date: 2011-03-04
• [Presentation] 変形性膝関節症治療のup-to-date(招待講演) (2010)
  • Author(s): 松田秀一
  • Organizer: 第67回DOC研究
  • Place of Presentation: 福岡市
  • Year and Date: 2010-09-02
• [Presentation] 変形性膝関節症治療のup-to-date (2010)
  • Author(s): 松田秀一
  • Organizer: 第67回 DOC研究会
  • Place of Presentation: 福岡市
  • Year and Date: 2010-09-02
• [Presentation] Statins prevent production of monocyte chemoattractant protein-l and matrixmetalloproteinase-s in IL-I stimulated synoviocytes through inhibition of protein isoprenylation (2009)
  • Author(s): Akasaki Y, Matsuda S, Nakayama K, Fukagawa S, Miura H, Iwamoto Y.
  • Organizer: The 55th Annual Meeting of the Orthopaedic Research Society
  • Place of Presentation: Las Vegas, USA