| Project/Area Number |
21591950
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YONEKURA Akihiko 長崎大学, 大学院・医歯薬学総合研究科, 助教 (20380850)
KAJIYAMA Shiro 長崎大学, 大学院・医歯薬学総合研究科, 助教 (90418822)
進藤 裕幸 長崎大学, 病院, 教授 (30107677)
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| Research Collaborator |
ANDREI P. sommer
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 関節炎 / 変形性関節症 / 関節リウマチ / 外傷後関節炎 / 石灰化 / 関節液 / 大動脈石灰化 |
|---|
| Research Abstract |
It has been reported that" calcifying nanoparticles(CNPs)" induce local inflammation and cell death around them in the human bodies. This study showed that synovial fluid of patients who suffered from osteoarthritis, rheumatoid arthritis and post-traumatic arthritis contained nanoparticles those sizes were less than 1000nm. The size of nanoparticles from osteoarthritis was less than 100nm, and therefore they were thought to be" calcifying nanoparticles" and they could play significant roles in calcification and ossification around the osteoarthritic joints.
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