From analysis of osteopontin function to development of preventive and medical treatment for osteoporosis.

Research Project

Project/Area Number	21591951
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Orthopaedic surgery
Research Institution	Oita University
Principal Investigator	HIGUCHI Yasunori 大分大学, 全学研究推進機構, 教授 (60040284)
Co-Investigator(Kenkyū-buntansha)	KATAOKA Masashi 大分大学, 医学部, 准教授 (40301379)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	オステオポンチン / 骨粗鬆症 / トランスジェニックマウス / 遺伝子改変マウス / 応用動物 / 老化
Research Abstract	We generated transgenic(OPN-TG) mice expressing osteopontin(OPN) which is a phosphoglycoprotein secreted by osteoblasts mainly. We found that an increase of calcium and type I collagen cross linked N teropeptide(NTx) in serum of OPN-TG mice, compared with normal mice. OPN-TG mice showed a decrease of bone density obtained by QCT and so is a useful model of human osteoporosis. Furthermore, we need in vitro analysis of the bone marrow cells with OPN-related proteins or peptides.