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Importance of tailor-made treatment for primary osteoporosis : Evaluation based on measurements of bone density and bone quality.

Research Project

Project/Area Number 21591962
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

SAITO Mitsuru  東京慈恵会医科大学, 医学部, 准教授 (50301528)

Co-Investigator(Kenkyū-buntansha) NISHIZAWA Tetsuro  東京慈恵会医科大学, 医学部, 助教 (50439791)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords原発性骨粗鬆症 / 骨質 / 骨密度 / 動物モデル / テーラーメード治療
Research Abstract

Biochemical markers of bone quality following administration of different pharmacological agents were measured in a rabbit hyperhomocysteinemia model(an experimental model of reduced human bone quality) developed in our laboratory. The results clearly indicated, similarly to our previously reported findings on human reduced-bone-quality-type osteoporosis that by incurring direct detrimental changes on collagen coss-links homocysteine reduces bone strength ; this mechanism is independent of reduction in bone density.
Additionally, based on findings that estrogen receptor modulators are more effective in patients with reduced-bone-quality-type osteoporosis, we suggest subdividing patients accordingly with the type of osteoporosis upon diagnosis and treatment of the disease.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (74 results)

All 2011 2010 2009 Other

All Journal Article (33 results) (of which Peer Reviewed: 31 results) Presentation (30 results) Book (10 results) Remarks (1 results)

  • [Journal Article] Effects of alfacalcidol on mechanical properties and collagen cross-links of the femoral diaphysis in glucocorticoid-treated rats2011

    • Author(s)
      Saito M, Marumo K, at al
    • Journal Title

      Calcified Tissue International

      Volume: 88 Pages: 314-324

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone(1-34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys2011

    • Author(s)
      Saito M, Marumo K, at al
    • Journal Title

      Osteoporosis International

      Volume: 22 Pages: 2373-2383

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Non-enzymatic crosslinking pentosidine increase in bone collagen and are associated with disorders of bone mineralization in dialysis patients2011

    • Author(s)
      Mitome J, Yamamoto H, Saito M, at al
    • Journal Title

      Calcified Tissue International

      Volume: 88 Pages: 521-529

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary pentosidine improves risk classification using fracture risk assessment tools for postmenopausal women2011

    • Author(s)
      Tanaka S, Kuroda T, Saito M, et al
    • Journal Title

      J Bone Miner Res

      Volume: 26 Pages: 2778-84

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis under bisphosphonate treatment2011

    • Author(s)
      Shiraki M, Kuroda T, Saito M, at al
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 29 Pages: 62-70

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症治療のテーラーメイド化と薬剤選択.骨強度の規定因子の多様性における骨密度と骨質の関与-2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      THE BONE

      Volume: 25 Pages: 25-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with human parathyroid hormone (1-34) for 18 months contribute to improvement of bone strength in ovariectomized monkeys2011

    • Author(s)
      Saito M, Marumo K, at al
    • Journal Title

      Osteoporosis International

      Volume: 22 Pages: 2373-83

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-enzymatic crosslinking pentosidine increase in bone collagen and are associated with disorders of bone mineralization in dialysis patients2011

    • Author(s)
      Mitome J, Saito M, at al
    • Journal Title

      Calcified Tissue International

      Volume: 88 Pages: 521-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic superoxide causes bone fragility due to low turnover osteoporosis with impaired collagen cross-inks2011

    • Author(s)
      Nojiri H, Saita Y, Saito M, et al
    • Journal Title

      J Bone Miner Res

      Volume: 26 Pages: 2682-94

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性閉塞性肺疾患(COPD)における骨脆弱化機序の解明-全身性(骨・肺・血管・皮膚・血液・尿)コラーゲン分析をもとに-2011

    • Author(s)
      斎藤充, 木田吉城, 丸毛啓史, 他
    • Journal Title

      Osteoporosis Japan

      Volume: 19 Pages: 8-11

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症治療のテーラーメード化と薬剤選択-骨強度の規定因子の多様性における骨密度と骨質の関与2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      THE BONE

      Volume: 25 Pages: 25-32

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 新しい医療技術:骨質マーカーとしての血清ペントシジンとホモシステイン2011

    • Author(s)
      斎藤充, 木田吉城, 丸毛啓史, 他
    • Journal Title

      整形・災害外科

      Volume: 54 Pages: 723-729

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症:骨質:Beyond BMD.材質特性と骨強度,骨質評価のエビデンス,BMD測定との独立性2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      Bone Joint Nerve

      Volume: 1 Pages: 279-87

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症の進歩:骨の材質特性の評価法の進歩と基質コラーゲンのAGE化2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      腎と骨代謝

      Volume: 24 Pages: 263-272

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 卒後研修講座:骨粗鬆症に対するテーラーメード治療の実際-骨密度・骨質マーカー同時評価の重要性-2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      整形外科

      Volume: 62 Pages: 1209-18

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症診療の最近の進歩-骨質をどのように評価するか2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      整形外科

      Volume: 49 Pages: 977-85

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨粗鬆症Q&A(第35回)骨質の評価法について教えてください(Q&A)2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Journal Title

      骨粗鬆症治療

      Volume: 10 Pages: 155-64

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of alfacalcidol on mechanical properties and collagen cross-links of the femoral diaphysis in glucocorticoid-treated rats.2011

    • Author(s)
      Saito M, Marumo K, at al.
    • Journal Title

      Calcified Tissue International

      Volume: 88 Pages: 314-324

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinary pentosidine and plasma homocysteine levels at baseline predict future fractures in osteoporosis under bisphosphonate treatment.2011

    • Author(s)
      Shiraki M, Saito M, at al.
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 29 Pages: 62-70

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen cross-links as a determinant of bone quality : a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus2010

    • Author(s)
      Saito M, Marumo K
    • Journal Title

      Osteoporosis International

      Volume: 21 Pages: 195-214

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia2010

    • Author(s)
      Saito M, Marumo K, Soshi S, et al
    • Journal Title

      Osteoporosis International

      Volume: 21 Pages: 655-666

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repair rat model2010

    • Author(s)
      Saito M, Shiraishi A, Ito M, et al
    • Journal Title

      Bone

      Volume: 48 Pages: 1170-1179

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] High level of serum undercarboxylated osteocalcin in patients with incident fractures during bisphosphonate treatment2010

    • Author(s)
      Shiraki M, Yamazaki Y, Saito M, et al
    • Journal Title

      J Bone Miner Metab

      Volume: 28 Pages: 578-584

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The fracture and immobilization score for risk assessment of osteoporotic 2 fracture and immobilization in postmenopausal women.2010

    • Author(s)
      Tanaka S, Saito M, at al.
    • Journal Title

      Bone

      Volume: 47 Pages: 1064-1070

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Raloxifene ameliorates detrimental collagen cross-link formation and bone strength in rabbits with hyperhomocysteinemia.2010

    • Author(s)
      Saito M, Maruino K, at al.
    • Journal Title

      Osteoporosis International 21

      Pages: 655-666

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of effects of alfacalcidol and alendronate on mechanical properties and bone collagen cross-links of callus in the fracture repairrat model.2010

    • Author(s)
      Saito M, Marumo K, at al.
    • Journal Title

      Bone 46

      Pages: 1170-1179

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Collagen cross-links as a determinant of bone quality : a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus2010

    • Author(s)
      Saito M, Marumo K.
    • Journal Title

      Osteoporosis International, (REVIEW) 21

      Pages: 195-214

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incorporation of tenascin-C into the extracellular matrix by periostin underlies an extracellular meshwork architecture.2010

    • Author(s)
      Kii I, Saito M, at al.
    • Journal Title

      Journal of Biological Chemistry 285

      Pages: 2028-2039

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of alendronate on bone formation and osteoclastic resorption after implantation of beta-tricalcium phosphate.2010

    • Author(s)
      Tanaka T, Saito M, at al.
    • Journal Title

      L Biomed Mater Res A. 93

      Pages: 469-474

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between periostin and BMP-1 promotes proteolytic activation of lysyl oxidase.2010

    • Author(s)
      Maruhashi T, Saito M, at al.
    • Journal Title

      Journal of Biological Chemistry (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.2009

    • Author(s)
      Murakami K, Saito M, at al.
    • Journal Title

      Biochem Biophys Res Commun. 382

      Pages: 457-461

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      斎藤充
    • Journal Title

      CKD-MBD病態解明のトピックス-骨質は何で決まるか-(日本メディカルセンター(東京))

      Pages: 239-245

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      斎藤充
    • Journal Title

      骨軟化症.今日の治療指針-私はこう治療している-(医学書院(東京))

      Pages: 875-876

    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨の材質劣化の原因と薬剤による改善作用2011

    • Author(s)
      斎藤充
    • Organizer
      第13回日本骨粗鬆症学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-03
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨粗鬆症:骨質の視点からの薬剤の適応と選択2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト組織分析をもとにした骨脆弱化動物モデルの確立と薬効評価のpitfall-齧歯類・家兎・イヌ・サルでの検討-2011

    • Author(s)
      斎藤充
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨粗鬆症:骨質の視点からの薬剤の適応と選択2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋(シンポジウム)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト組織分析をもとにした骨脆弱化動物モテルの確立と楽効評仙のpitfall-齧歯類・家兎・イヌ・サルでの検討-2011

    • Author(s)
      斎藤充
    • Organizer
      第26回日本整形外科学会基礎学術集会
    • Place of Presentation
      前橋
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 変形性関節症と骨粗鬆症の接点-病態からみたビスフォスフォネートおよびSERMの可能性-2011

    • Author(s)
      斎藤充
    • Organizer
      第38回日本股関節学会
    • Place of Presentation
      鹿児島
    • Year and Date
      2011-10-07
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨密度・骨質マーカー同時評価に基づく治療薬の使い分け-PTH製剤の骨量・骨質改善効果2011

    • Author(s)
      斎藤充
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨質因子の制御機構-コラーゲンの架橋形成はリモデリングのみに規定されない2011

    • Author(s)
      斎藤充
    • Organizer
      第31回日本骨形態計測学会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 生活習慣病に伴う骨折リスク増大の機序-AGEs・酸化ストレスによる骨質劣化の基礎からテーラーメード治療まで-2011

    • Author(s)
      斎藤充
    • Organizer
      第54回日本糖尿病学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨質劣化型骨折の予防と治療:骨質マーカーの可能性について2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第84回日本整形外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 尿中コラーゲン老化マーカー(ペントシジン)および血中ホモシステイン高値は変形性膝関節症の独立した危険因子である2011

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第84回日本整形外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] テーラーメード治療のエビデンス-骨質劣化型骨粗鬆症に対する新規SERMsの可能性-2011

    • Author(s)
      斎藤充
    • Organizer
      第84回日本整形外科学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨質劣化型骨折の予防と治療:骨質マーカーの可能性について2011

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第84回日本整形外科学会学術総会
    • Place of Presentation
      横浜(シンポジウム)
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] なぜ高い骨密度で骨折するのか?-ステロイド・AGEs・酸化ストレスによる骨質劣化の基礎からテーラーメード治療まで-2011

    • Author(s)
      斎藤充
    • Organizer
      第84回日本内分泌学会学術総会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 生活習慣病と骨粗鬆症. 生活習慣病における骨質劣化機序2010

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第13回日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症の病態と診断に関する考え方2010

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第13回日本骨粗鬆症学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床へつながる基礎研究の立案とピットフォール「骨質研究からみたバイオマーカーの確立とテーラーメード治療への応用」2010

    • Author(s)
      斎藤充
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症における骨質の異常からみた骨粗鬆症治療薬の使い分け2010

    • Author(s)
      斎藤充
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症治療薬およびメカニカルストレスが骨折治癒過程のコラーゲン架橋形成および骨強度に及ぼす影響2010

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症治療薬としてのPTH(1-34)が骨量・骨質・骨強度に及ぼす影響2010

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨粗鬆症の治療とその評価をどのように行うか 骨質の評価 骨質マーカー(ホモシステイン,ペントシジン,eGFR)による骨折リスク評価のエビデンス2010

    • Author(s)
      斎藤充, 丸毛啓史
    • Organizer
      第83回日本整形外科学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨質関連マーカー(ホモシステイン,ペントシジン)を用いたビスフォスフォネート治療効果の予測に関する前向き多施設共同研究2010

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第83回日本整形外科学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Onece-weekly treatment with human parathyroid hormone(1-34) for 18 months increases bone strength via the amelioration of microarchitecture, degree of mineralization, enzymatic and non-enzymatic cross-link formation in ovariectomized cynomolgus monkeys.2010

    • Author(s)
      Saito M, Marumo K, at al.
    • Organizer
      IOF World Congress on Osteoporosis
    • Place of Presentation
      Denver, U.S.A.
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨質関連マーカー(ホモシステイン,ペントシジン,eGFR)を用いた骨粗鬆症に対するテーラーメード治療の実際2010

    • Author(s)
      斎藤充
    • Organizer
      第114回中部整形災害外科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Collagen cross-links as a determinant of bone quality : a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus2010

    • Author(s)
      Saito M, Marumo K.
    • Organizer
      The 14^<th> International Congress of Endocrinoligy
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-03-31
    • Related Report
      2009 Annual Research Report
  • [Presentation] エルカトニンあるいはアレントロネート投与が骨質に及ぼす影響-成熟サルに対する6ヵ月投与の検討-2009

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Weekly treatment with human parathyroid hormone (1-34) for 18 months increases bone strength via the amelioration of microarchitecture, degree of mineralization, enzymatic and non-enzymatic cross-link formation in ovariectomized cynomolgus monkeys.2009

    • Author(s)
      Saito M, Marumo K, at al.
    • Organizer
      The 31^<st> annual meeting of The America Society for Bone and Mineral Research
    • Place of Presentation
      Denver, U.S.A
    • Year and Date
      2009-09-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨質・構造と骨粗鬆症:材質Overview:コラーゲン・マイクロダメージ・石灰化度(シンポジウム)2009

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] アレンドロネートあるいはエルカトニン投与がコラーゲンの成熟度・老化度に及ぼす影響-成熟サルに対する6ヵ月投与の検討-2009

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 変形性関節症と骨粗鬆症の接点:変形性関節症の病態(骨代謝亢進・軟骨基質の老化)から考えるビスフォスフォネートの可能性(シンポジウム)2009

    • Author(s)
      斎藤充, 丸毛啓史, 他
    • Organizer
      第53回日本リウマチ学会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-24
    • Related Report
      2009 Annual Research Report
  • [Book] 酸化ストレスと糖尿病合併症:骨粗鬆症2011

    • Author(s)
      斎藤充
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Book] 相互に関連? 3大疾患:骨代謝におけるAEGの蓄積2011

    • Author(s)
      斎藤充
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Final Research Report
  • [Book] 相互に関連?3大疾患:骨代謝におけるAEGの蓄積2011

    • Author(s)
      斎藤充
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] マネージメントシリーズ.材質特性と骨質2010

    • Author(s)
      斎藤充
    • Publisher
      医薬ジャーナル
    • Related Report
      2011 Final Research Report
  • [Book] 糖化による疾患と抗糖化食品・素材.加齢に伴う骨へのAGEsの蓄積と骨折リスク2010

    • Author(s)
      斎藤充
    • Publisher
      シーエムシー出版
    • Related Report
      2011 Final Research Report
  • [Book] 骨代謝マーカー改訂版.各種マーカーとその特徴2010

    • Author(s)
      斎藤充
    • Publisher
      医薬ジャーナル
    • Related Report
      2011 Final Research Report
  • [Book] マネージメントシリーズ. 材質特性と骨質2010

    • Author(s)
      斎藤充
    • Publisher
      医薬ジャーナル
    • Related Report
      2010 Annual Research Report
  • [Book] 糖化による疾患と抗糖化食品・素材. 加齢に伴う骨へのAGEsの蓄積と骨折リスク2010

    • Author(s)
      斎藤充
    • Publisher
      シーエムシー出版
    • Related Report
      2010 Annual Research Report
  • [Book] 骨代謝マーカー改訂版. 各種マーカーとその特徴2010

    • Author(s)
      斎藤充
    • Publisher
      医薬ジャーナル
    • Related Report
      2010 Annual Research Report
  • [Book] CKD-MBD病態解明のトピックス-骨質は何で決まるか-2009

    • Author(s)
      斎藤充
    • Publisher
      日本メディカルセンター
    • Related Report
      2011 Final Research Report
  • [Remarks] 東京慈恵会医科大学整形外科学講座

    • URL

      http://www.jikeiseikei.com

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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