| Project/Area Number |
21591971
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Toji 滋賀医科大学, 医学部, 非常勤講師 (20116122)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
AKIYAMA Tshuyoshi 国立循環器病センター(研究所), 心臓生理部, 室長 (70202554)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | マイクロダイアリシス法 / 心筋保護 / ミオグロビン / セボフルラン / 心筋バイアビリティ / マイクロダイアリシス / 麻酔薬 |
|---|
| Research Abstract |
Using microdialysis technique, we examined the effects of volatile anesthetics on ischemic myocardial injury. Ischemia induced dialysate myoglobin(as one of the cardiac muscle proteins) release was suppressed by 1MAC sevoflurane or isoflurane administration before ischemia. Desipramine(cell injury-induced drug) induced myoglobin release after ischemia was augmented by 1MAC sevoflurane administration before ischemia. It suggested sevoflurane administration before ischemia attenuated myocardial injury and preserved viability.
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