Clarify the role of mu receptor endocytosis in spinal analgesia and opioid tolerance
Project/Area Number |
21591972
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Shimane University |
Principal Investigator |
SAITO Yoji 島根大学, 医学部, 教授 (50162243)
|
Co-Investigator(Kenkyū-buntansha) |
HASHIMOTO Tatsuya 島根大学, 医学部, 講師 (00372681)
NIKAI Tetsuro 島根大学, 医学部, 講師 (20314643)
IMAMACHI Noritaka 島根大学, 医学部, 講師 (40325048)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | オピオイド作動薬 / μオピオイド受容体細胞内動態 / 耐性 / 脊髄鎮痛 / オピオイド / 細胞内陥入 / 体性痛 / 内臓痛 / 受容体細胞内動態 |
Research Abstract |
Oxycodone induced mu opioid receptor endocytosis in different manner, such as DAMGO or morphine. It was thought that this result could clarify the role of mu opioid receptor endocytosis in spinal analgesia and opioid tolerance.
|
Report
(4 results)
Research Products
(2 results)