Clarify the role of mu receptor endocytosis in spinal analgesia and opioid tolerance

Research Project

Project/Area Number	21591972
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Shimane University
Principal Investigator	SAITO Yoji 島根大学, 医学部, 教授 (50162243)
Co-Investigator(Kenkyū-buntansha)	HASHIMOTO Tatsuya 島根大学, 医学部, 講師 (00372681) NIKAI Tetsuro 島根大学, 医学部, 講師 (20314643) IMAMACHI Noritaka 島根大学, 医学部, 講師 (40325048)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	オピオイド作動薬 / μオピオイド受容体細胞内動態 / 耐性 / 脊髄鎮痛 / オピオイド / 細胞内陥入 / 体性痛 / 内臓痛 / 受容体細胞内動態
Research Abstract	Oxycodone induced mu opioid receptor endocytosis in different manner, such as DAMGO or morphine. It was thought that this result could clarify the role of mu opioid receptor endocytosis in spinal analgesia and opioid tolerance.

Report

(4 results)