| Project/Area Number |
21591974
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Yamaguchi University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Atsuo 山口大学, 医学部附属病院, 助教 (50379971)
WAKAMATSU Hiroya 山口大学, 医学部附属病院, 講師 (80379966)
FUKUDA Shiro 山口大学, 大学院・医学系研究科, 講師 (70322245)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
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| Keywords | 脊髄虚血 / インスリン様成長因子1 / エリスロポエチン / Akt / 脊髓虚血 / 硬膜外電気刺激 |
|---|
| Research Abstract |
One of the devastating complications after thoracoabdominal aortic surgery is paraplegia. Paraplegia is thought to be a result of spinal cord ischemia during aortic occlusion. To protect against ischemic spinal cord injury, many drugs have been tested in animal experiments. However, no drugs have been established as being protective in the clinical setting. In this study, we found that the combination of erythropoietin and insulin-like growth factor 1 given just after reperfusion protects against ischemic spinal cord injury in a transient spinal cord ischemia model in rabbits.
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