The role and the control method of autophagy at systemic inflammation

• Project/Area Number: 21591977
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Oita University
• Principal Investigator: HAGIWARA Satoshi 大分大学, 医学部, 講師 (50527661)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: オートファジー / 敗血症 / エンドトキシン / 静脈栄養 / 炎症

Research Abstract

Autophagy is activated at systemic inflammation. This activation may contribute to the inflammatory process and tissue injury observed after systemic inflammation. On the other hand, adequate nutrition improves systemic inflammation by reducing autophagy.

Research Products

• [Journal Article] Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus (2010)
  • Author(s): Hagiwara S, Iwasaka H, Koga H, Hasegawa A, Kudo K, Kusaka J, Oyama Y, Noguchi T
  • Journal Title: Biomed Res
  • NAID: 130004903804
• [Journal Article] Infusion of a Glucose Solution Reduces Autophagy in the Liver after LPS-induced Systemic Inflammation
  • Author(s): Hagiwara S, Iwasaka H, Hasegawa A, Kudo K, Kusaka J, Oyama Y, Noguchi T
  • Journal Title: Inflammation Volume: (in press)
• [Presentation] 重症患者管理における臓器保護戦略 (2010)
  • Author(s): 萩原聡
  • Organizer: 関東甲信越
  • Place of Presentation: 集中治療地方会
• [Presentation] 敗血症モデルでの病態形成におけるオートファジーの関与について (2009)
  • Author(s): 今冨良太、岩坂日出男、長谷川輝、萩原聡、野口隆之
  • Organizer: 第15回日本エンドトキシン研究会