Effects of anesthetics on orexin cell-Is orexin system a target of anesthetics-
| Project/Area Number |
21591979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YONAHA Tetsu 宮崎大学, 医学部, 助教 (70468023)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 脳・神経 / 薬理学 / 生理学 / 生理活性 / 麻酔 / オレキシン |
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| Research Abstract |
The electrophysiological characteristics of ORX cell in perifornical area(PFH) and lateral hypothalamus(LH) is wide action potential and biphasic wave form which are different from surrounding cells in the hypothalamus. It is appeared that they frequently firing during awake period more than sleep period. ORX cells indicated various responses against several anesthetics(sevoflurane, propofol, dexmedetomidine, ketamine, muscimol) in conscious freely moving rats. The Chenges in ORX cell activity were accordance with the changes in EEG.
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Report
(4 results)
Research Products
(9 results)
