Protective potentials of erythropoietin against neurotoxicity of general anesthetics on immature brain.

• Project/Area Number: 21591980
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Yokohama City University
• Principal Investigator: ECHIGO Noriyuki 横浜市立大学, 医学研究科, 客員准教授 (00363797)
• Co-Investigator(Kenkyū-buntansha): ANDOH Tomio 横浜市立大学, 医学研究科, 客員教授 (00193110) ; KAMIYA Yoshinori 横浜市立大学, 医学部, 助教 (90381491)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: エリスロポエチン / 新生児 / 神経保護 / 神経細胞死 / 麻酔薬 / エリスロポイエチン / 神経毒性

Research Abstract

General anesthetics are shown to induce wide spread apoptosis in the developing brain. We studied if erythropoietin (Epo) affords protection against anesthetic-induced neurotoxicity in neonatal rats. We found that neuroapoptosis was induced in the cerebral cortex and hypocampus after 6 hour exposure to general anesthetics. Intranasal and intraperitoneal administration of Epo failed to inhibit apoptosis. The results suggest that Epo is not effective in inhibiting anesthetic-induced neurotoxicity in immature brain.

Research Products

• [Journal Article] Effects of erythropoietin on intracellular calcium concentration of rat primary cortical neurons (2011)
  • Author(s): T.Andoh, N.Echigo, Y.Kamiya, et al
  • Journal Title: Brain Research Volume: 1387 Pages: 8
  • DOI: 10.1016/j.brainres.2011.02.077
  • Peer Reviewed
• [Journal Article] エリスロポエチンの神経保護作用とその臨床効果 (2009)
  • Author(s): 安藤富男
  • Journal Title: 帝京医学会雑誌 Volume: 32巻 Pages: 319-328
  • Peer Reviewed
• [Presentation] 幼若ラットへのイソフルレン暴露による海馬アポトーシスに対してエリスロポエチンに保護作用はあるか? (2012)
  • Author(s): 内本一宏、後藤隆久、安藤富男
  • Organizer: 日本麻酔科学会第59回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-06-07
• [Presentation] 病態時の神経細胞内カルシウム濃度に対するErythropoietinの効果 (2010)
  • Author(s): 越後憲之、紙谷義孝、安藤富男, ほか
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡市 福岡国際会議場
  • Year and Date: 2010-06-02