Protective potentials of erythropoietin against neurotoxicity of general anesthetics on immature brain.
| Project/Area Number |
21591980
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
ECHIGO Noriyuki 横浜市立大学, 医学研究科, 客員准教授 (00363797)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ANDOH Tomio 横浜市立大学, 医学研究科, 客員教授 (00193110)
KAMIYA Yoshinori 横浜市立大学, 医学部, 助教 (90381491)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | エリスロポエチン / 新生児 / 神経保護 / 神経細胞死 / 麻酔薬 / エリスロポイエチン / 神経毒性 |
|---|
| Research Abstract |
General anesthetics are shown to induce wide spread apoptosis in the developing brain. We studied if erythropoietin (Epo) affords protection against anesthetic-induced neurotoxicity in neonatal rats. We found that neuroapoptosis was induced in the cerebral cortex and hypocampus after 6 hour exposure to general anesthetics. Intranasal and intraperitoneal administration of Epo failed to inhibit apoptosis. The results suggest that Epo is not effective in inhibiting anesthetic-induced neurotoxicity in immature brain.
|
Report
(4 results)
Research Products
(4 results)
