The mechanisms of the effect of statin on acute improvement of endothelial dysfunction

• Project/Area Number: 21591986
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Wakayama Medical University
• Principal Investigator: SETO Yoko 和歌山県立医科大学, 医学部, 助教 (30433353)
• Co-Investigator(Kenkyū-buntansha): OGAWA Koji 和歌山県立医科大学, 医学部, 准教授 (30204077)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: スタチン / 糖尿病 / 一酸化窒素 / 内皮型一酸化窒素合成酵素 / Phosphoinositole 3-kinase / Aktタンパク質 / AKTタンパク質 / 血管内皮細胞

Research Abstract

In diabetes model, simvastatin exposure to cultured endothelial cells increased the nitric oxide(NO) production. PI_3K inhibitor inhibited the increase in eNOS expression in response to simvastatin, but phosphorylation of Akt protein was not affected by simvastatin. It is suggested that direct effect of PI3K without through Akt protein pathway may be involved in the statin induced activation of eNOS-NO signaling pathways.

Research Products

• [Journal Article] Sevoflurane does not alter norepinephrine-induced intracellular Ca2+changes in the diabetic rat aorta (2010)
  • Author(s): Fujii K, Ogawa K, Tokinaga Y, Iranami H, Hatano Y
  • Journal Title: Can J Anesth Volume: 57 Pages: 1095-1101
  • Peer Reviewed
• [Journal Article] The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction (2010)
  • Author(s): Shimogai M, Ogawa K, Tokinaga Y, Yamazaki A, Hatano Y
  • Journal Title: J Anesth Volume: 24 Pages: 893-900
  • NAID: 10027741425
  • Peer Reviewed
• [Journal Article] Differential vasodilation response to olprinone in rabbit renal and common carotid arteries (2010)
  • Author(s): Minonishi T, Ogawa K, Tokinaga Y, Negoro T, Kimoto Y, Hatano Y
  • Journal Title: J Anesth Volume: 24 Pages: 61-66
  • NAID: 10027265635
  • Peer Reviewed
• [Journal Article] Sevoflurane does not alter norepinephrine-induced intracellular Ca^<2+> changes in the diabetic rat aorta (2010)
  • Author(s): Fujii K, Ogawa K, Tokinaga Y, Iranami H, Hatano Y
  • Journal Title: Can J Anesth Volume: 57 Pages: 1995-1101
  • Peer Reviewed
• [Journal Article] The cellular mechanisms underlying the inhibitory effects of isoflurane and sevoflurane on arginine vasopressin-induced vasoconstriction. (2010)
  • Author(s): Shimogai M, Ogawa K, Tokinaga Y, Yamazaki A, Hatano Y
  • Journal Title: J Anesth Volume: 24 Pages: 893-900
  • NAID: 10027741425
  • Peer Reviewed
• [Presentation] The Effect of Sevoflurane on Simvastatin-Induced eNOS Expression in Cultured Endothelial Cells. (2010)
  • Author(s): Tange K, Kawashima K, Tokinaga Y, Ogawa K, Hatano Y
  • Organizer: 2010 Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-18
• [Presentation] The Effect of Sevoflurane on Simvastatin-Induced eNOS Expression in Cultured Endothelial Cells. (2010)
  • Author(s): Tange K, Kawashima K, Tokinaga Y, Ogawa K, Hatano Y
  • Organizer: 2010 Annual Meeting of American Society of Anesthesiologists
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2010-10-18