| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Volatile anesthetic directly protects mitochondrial function independently from cytosolic signaling pathways in anesthetic postconditioning. Nicorandil, coronary vasodilatation agent used in the management of angina during perioperative period, also directly protects isolated mitochondrial bioenergetics through nitric oxide, independent of its effects on the cytosolic signal transduction cascade. These results indicate that immediate protective benefits on mitochondrial function independently from the cytosolic environment may contribute to the cardioprotective effects provided by pharmacological postconditioning.
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