Cell biological analysis of the effect of hypoxia-induced gene expressions on progression of pulmonary alveolar inflammation
Project/Area Number |
21591992
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
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Research Institution | 公益財団法人田附興風会 (2011) Tazuke Kofukai Medical Research Institute (2009-2010) |
Principal Investigator |
ADACHI Takehiko 公益財団法人田附興風会, 医学研究所第9研究部, 部長 (90252428)
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Co-Investigator(Kenkyū-buntansha) |
HIROTA Kiichi 京都大学, 医学研究科, 准教授 (00283606)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 肺胞上皮 / 肺障害 / 低酸素誘導性因子1 / タバコ / 水チャネル / 遺伝子発現 |
Research Abstract |
Systemic shock manifested as a symptom of sepsis and tabaco smoking disturb physiological homeostasis and induces phothophysiological changes in epithelium, interstitial tissue and capillary vessels of pulmonary alveoli as a unit of gas exchange. To review these pathological phenomena from the point of signal transduction and gene expression elicited by systemic and tissue hypoxia and understand molecular mechanisms behind the phenomena, we analysed cells and mice adopting methodology of molecular biology in relation to hypoxia-inducible factor 1 activity.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells2009
Author(s)
Oda, S., Oda, T., Takabuchi, S., Nishi, K., Wakamatsu, T., Tanaka, T., Adachi, T., Fukuda, K., Nohara, R., and Hirota, K.
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Journal Title
Eur J Pharmacol
Volume: 606
Issue: 1-3
Pages: 130-136
DOI
Related Report
Peer Reviewed
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[Presentation] ハイポキシア生物学2009
Author(s)
広田喜一
Organizer
日本麻酔科学会第56回学術集会
Place of Presentation
神戸ポートピアホテル(兵庫県)
Year and Date
2009-08-17
Related Report