Role of endogenous prostanoids in vascular remodeling

• Project/Area Number: 21591993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Asahikawa Medical College
• Principal Investigator: TAKAHATA Osamu 旭川医科大学, 医学部, 准教授 (60179546)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 内因性プロスタノイド / 血管リモデリング / プロスタノイド / 血管平滑筋 / リモデリング / 血管平滑筋細胞

Research Abstract

The intimal areas and medial areas two weeks after ligation of left common carotid arteries increased in both wild-type (WT) and EP4 receptor knockout (EP4^<-/->) mice. The intimal area four weeks after ligation was significantly increased in the ligated WT arteries compared with EP4^<-/-> arteries. I/M ratio and stenotic ration four weeks after blood flow cessation were also significantly increased in the ligated WT arteries compared with EP4^<-/->arteries. These results indicate that endogenous PGE2 plays an important role in intimal hyperplasia caused by blood-flow cessation via EP4 receptor.

Research Products

• [Journal Article] The intrinsic prostaglandin E(2)-EP(4) system of the renal tubular epithelium limits the development of tubulointerstitial fibrosis in mice (2012)
  • Author(s): Nakagawa N, Yuhki KI, Kawabe JI, Fujino T, Takahata O, 他9名
  • Journal Title: Kidney Int Volume: (in press) Issue: 2 Pages: 158-171
  • DOI: 10.1038/ki.2012.115
  • Peer Reviewed
• [Journal Article] Ideal body weight-based remifentanil infusion is potentially insufficient for anesthetic induction in mildly obese patients (2012)
  • Author(s): Kunisawa T, Mitamura S, Hanada S, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: (in press) Issue: 5 Pages: 790-793
  • DOI: 10.1007/s00540-012-1395-5
  • NAID: 10031123508
  • Peer Reviewed
• [Journal Article] Dexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypass (2011)
  • Author(s): Kunisawa T, Ueno M, Kurosawa A, Nagashima M, Hayashi D, Sasakawa T, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 25 Issue: 6 Pages: 818-22
  • DOI: 10.1007/s00540-011-1215-3
  • NAID: 10030448656
  • Peer Reviewed
• [Journal Article] Repeat dosing of rocuronium after reversal of neuromuscular block by sugammadex (2011)
  • Author(s): Matsuki G, Takahata O, Iwasaki H
  • Journal Title: Can J Anesth Volume: 58 Pages: 769-70
  • Peer Reviewed
• [Journal Article] Importance of model fitting when a non-commercial TCI system was used : taking Kataria's parameter as an example (2011)
  • Author(s): Kunisawa T, Kurosawa A, Hayashi D, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 25 Issue: 2 Pages: 314-5
  • DOI: 10.1007/s00540-011-1096-5
  • NAID: 10029022832
  • Peer Reviewed
• [Journal Article] Intraoperative evaluation of visceral arteries by transesophageal echocardiography in stanford B thoracic aortic dissection (2011)
  • Author(s): Tampo A, Kunisawa T, Kurosawa A, Takahata O, Iwasaki H
  • Journal Title: J Cardiothor Vasc Anesth Volume: 25 Issue: 3 Pages: 589-90
  • DOI: 10.1053/j.jvca.2010.07.015
  • Peer Reviewed
• [Journal Article] Confirmation of guidewire placement by ultrasound before tissue dilatation prevented damage to the internal jugular vein (2011)
  • Author(s): Kunisawa T, Kurosawa A, Osawa Y, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Cardiothor Vasc Anesth Volume: 25 Pages: 584-5
  • Peer Reviewed
• [Journal Article] スガマデクス使用後、短時間にロクロニウム再投与を必要とした4症例 (2011)
  • Author(s): 岩崎肇、松木郷、笹川智貴、高畑治、岩崎寛
  • Journal Title: 日本臨床麻酔学会誌 Volume: 31 Pages: 784-7
  • NAID: 10029770081
  • Peer Reviewed
• [Journal Article] 重症筋無力症患者におけるスガマデクス必要量を検討した1症例 (2011)
  • Author(s): 菅原亜美、笹川智貴、長谷川直義、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 60 Pages: 1082-5
  • Peer Reviewed
• [Journal Article] 腹部大血管手術術後における経静脈的鎮痛法の比較 (2011)
  • Author(s): 小野寺美子、山岸昭夫、国沢卓之、黒澤温、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 60 Pages: 936-40
  • Peer Reviewed
• [Journal Article] スガマデクスを使用後、短時間に再手術となりロクロニウム再投与を行った1症例 (2011)
  • Author(s): 笹川智貴、岩崎肇、黒澤温、菊地千歌、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 60 Pages: 621-4
  • Peer Reviewed
• [Journal Article] ICD植え込み術中に発症した急性心タンポナーデの診断に経食道心エコーが有用であった1例 (2011)
  • Author(s): 田中博志、神田浩嗣、笹川智貴、国沢卓之、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 35 Pages: 807-9
  • Peer Reviewed
• [Journal Article] Repeat dosing of rocuronium after reversal of neuromuscular block by sugammadex (2011)
  • Author(s): Matsuki G, Takahata O, Iwasaki H
  • Journal Title: Canadian Journal of Anesthesia Volume: 58 Issue: 8 Pages: 769-70
  • DOI: 10.1007/s12630-011-9520-8
  • Peer Reviewed
• [Journal Article] Confirmation of guidewire placement by ultrasound before tissue dilatation prevented damage to the internal jugular vein (2011)
  • Author(s): Kunisawa T, Kurosawa A, Osawa Y, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: Journal of Cardiothoracic and Vascular Anesthesia Volume: 25 Issue: 3 Pages: 584-5
  • DOI: 10.1053/j.jvca.2010.07.003
  • Peer Reviewed
• [Journal Article] Dexmedetomidine was safely used for sedation durign spinal anesthesia in a very elderly patient (2010)
  • Author(s): Kunisawa T, Hanada S, Kurosawa A, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 24 Pages: 938-41
  • Peer Reviewed
• [Journal Article] Accidental injection of remifentanil can cause a much more dangerous situation than the same dose of fentanyl (2010)
  • Author(s): Kunisawa T, Nagashima M, Suzuki A, Takahata O, Iwasaki H、
  • Journal Title: J Anesth Volume: 24 Issue: 6 Pages: 970-1
  • DOI: 10.1007/s00540-010-1008-0
  • NAID: 10027741813
  • Peer Reviewed
• [Journal Article] Awake intubation under sedation using target-controlled infusion of dexmedetomidine : five case reports (2010)
  • Author(s): Kunisawa T, Nagashima M, Hanada S, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 24 Pages: 789-92
  • NAID: 10027740970
  • Peer Reviewed
• [Journal Article] Bispectral index monitor prevented intraoperative awareness during partial cardiopulmonary bypass (2010)
  • Author(s): Kunisawa T, Ueno M, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Cardiothor Vasc Anesth Volume: 24 Pages: 740-740
  • Peer Reviewed
• [Journal Article] Efficacy of intrathecal morphine with epidural ropivacaine infusion for postcesarean analgesia (2010)
  • Author(s): Mikuni I, Hirai H, Toyama Y, Takahata O, Iwasaki H
  • Journal Title: J Clin Anesth Volume: 22 Issue: 4 Pages: 268-73
  • DOI: 10.1016/j.jclinane.2009.09.003
  • Peer Reviewed
• [Journal Article] The range of values of variable alpha when predicting plasma concentrations and/or effect site concentrations of remifentanil is huge (2010)
  • Author(s): Kunisawa T, Nagashima M, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 24 Issue: 4 Pages: 656-7
  • DOI: 10.1007/s00540-010-0961-y
  • Peer Reviewed
• [Journal Article] Combination of high-dose dexmedetomidine sedation and fascia iliaca compartment block for hip fracture surgery (2010)
  • Author(s): Kunisawa T, Ota M, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Clin Anesth Volume: 22 Issue: 3 Pages: 196-200
  • DOI: 10.1016/j.jclinane.2009.02.020
  • Peer Reviewed
• [Journal Article] レボブピバカインの術後鎮痛における使い方 (2010)
  • Author(s): 高畑治、林健太郎、鈴木昭広、菅原亜美、黒澤温
  • Journal Title: 日本臨床麻酔学会誌 Volume: 30 Pages: 131-8
  • NAID: 10026352919
  • Peer Reviewed
• [Journal Article] 挿管未経験者における各種喉頭鏡を用いた挿管試行の検討-Macintosh, Miller, AirtraqR, AirwayscopeRの比較 (2010)
  • Author(s): 高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 60 Pages: 389-94
  • Peer Reviewed
• [Journal Article] 重症筋無力症患者に対してレミフェンタニル目標制御注入を利用して麻酔管理を行った2症例 (2010)
  • Author(s): 阿部展子、国沢卓之、笹川智貴、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 59 Pages: 727-30
  • Peer Reviewed
• [Journal Article] 新しい声門器具i-gelの有用性-ラリンジアルマスクプロシールとラリンジアルチューブサクションを用いた比較検討 (2010)
  • Author(s): 菅原亜美、鈴木昭広、稲垣恭好、林健太郎、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 34 Pages: 729-32
  • Peer Reviewed
• [Journal Article] クスメデトミジンの初期負荷投与が小児心臓手術患者の血行動態に及ぼす影響 (2010)
  • Author(s): 林大、国沢卓之、黒澤温、長島道生、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 59 Pages: 362-5
  • Peer Reviewed
• [Journal Article] 麻酔導入後の経食道心エコーが術前診断の再評価に有用であった1症例 (2010)
  • Author(s): 上野恵、国沢卓之、長島道生、鈴木昭広、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 59 Pages: 101-3
  • Peer Reviewed
• [Journal Article] 腹部大動脈ー大腿動脈人工血管置換術における大動脈遮断解除前後のSVV変動と循環動態の検討 (2010)
  • Author(s): 山岸昭夫、国沢卓之、黒澤温、笹川智貴、上野恵、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 59 Pages: 197-201
  • Peer Reviewed
• [Journal Article] Dexmedetomidine suppresses the decrease in blood pressure during anesthetic induction and blunts the cardiovascular response to tracheal intubation (2009)
  • Author(s): Kunisawa T, Nagata O, Nagashima M, Mitamura S, Ueno M, Suzuki A, Takahata O, Iwasaki H
  • Journal Title: J Clin Anesth Volume: 21 Pages: 194-9
  • Peer Reviewed
• [Journal Article] The Pentax-AWS is particularly suitable for facilitating intubation in edentulous geriatric patients (2009)
  • Author(s): Yamamoto K, Suzuki A, Toyama Y, Sasakawa T, Kunisawa T, Takahata O, Iwasaki H
  • Journal Title: J Anesth Volume: 23 Pages: 471-471
  • NAID: 10027264542
  • Peer Reviewed
• [Journal Article] Stress-free tracheal tube exchange using Pentax-AWS (Airway Scope) (2009)
  • Author(s): Suzuki A, Kunisawa T, Aizawa K, Sasakawa T, Takahata O, Iwasaki H
  • Journal Title: J Cardiothor Vasc Anesth Volume: 23 Pages: 133-4
  • Peer Reviewed
• [Journal Article] Transvalvular leakage after the implantation of stented bovine pericardial valves is not only central (2009)
  • Author(s): Kunisawa T, Sasakawa T, Kishi M, Suzuki A, Takahata O, Iwasaki H、
  • Journal Title: J Anesth Volume: 23 Pages: 639-40
  • NAID: 10027265381
  • Peer Reviewed
• [Journal Article] デクスメデトミジンTCIを用いて、PCPS下に緊急気管切開術を施行した1例 (2009)
  • Author(s): 岸真衣、国沢卓之、黒澤温、三田村小百合、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 33 Pages: 1742-6
  • Peer Reviewed
• [Journal Article] 心大血管手術におけるデクスメデトミジンの麻酔薬節約効果の検討 (2009)
  • Author(s): 神田浩嗣、国沢卓之、黒澤温、長島道生、鈴木昭広、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 58 Pages: 1496-500
  • Peer Reviewed
• [Journal Article] 重症筋無力症患者の周術期管理におけるデクスメデトミジンの使用経験 (2009)
  • Author(s): 勝見紀文、国沢卓之、鈴木昭広、黒澤温、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 58 Pages: 1450-2
  • Peer Reviewed
• [Journal Article] 挿管困難を伴ったCornelia de Lange症候群におけるエアトラックペディの使用経験 (2009)
  • Author(s): 岸 真衣、鈴木昭広、国沢卓之、黒澤温、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 33 Pages: 1295-8
  • Peer Reviewed
• [Journal Article] プロポフォール、レミフェンタニル、デクスメデトミジンを用いて行ったNoonan症候群の麻酔経験 (2009)
  • Author(s): 小野寺美子、山岸昭夫、国沢卓之、黒澤温、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 33 Pages: 1145-9
  • NAID: 120005023345
  • Peer Reviewed
• [Journal Article] 重症筋無力症患者に対し、Orchestraを利用して麻酔管理を行った1症例 (2009)
  • Author(s): 国沢卓之、山口卓、後藤祐也、鈴木昭広、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 33 Pages: 895-7
  • Peer Reviewed
• [Journal Article] 連続的心拍出量モニターPulseCOTMの有用性-経食道心エコ-(TEE)による校正 (2009)
  • Author(s): 山岸昭夫、国沢卓之、長島道生、高畑治、岩崎寛
  • Journal Title: 麻酔 Volume: 58 Pages: 422-5
  • Peer Reviewed
• [Journal Article] デクスメデトミジンTCI、フェンタニルTCIを用いた覚醒下腱剥離術の1症例 (2009)
  • Author(s): 後藤祐也、国沢卓之、藤本一弘、鈴木昭広、高畑治、岩崎寛
  • Journal Title: 臨床麻酔 Volume: 33 Pages: 27-40
  • Peer Reviewed
• [Journal Article] 下肢切断術の術中・術後の心房細動に使用した塩酸ランジオロールの薬物動態シミュレーション (2009)
  • Author(s): 山岸昭夫、国沢卓之、高橋桂哉、高畑治、岩崎寛
  • Journal Title: ICUとCCU Volume: 32 Pages: 235-40
  • Peer Reviewed
• [Presentation] Duration and variability of the action of rocuronium in very elderly patients (2011)
  • Author(s): Takahata O
  • Organizer: Annual Meeting American Society of Anesthesiologists
  • Place of Presentation: シカゴ
  • Year and Date: 2011-10-16
• [Presentation] Duration and variability of the action of rocuronium in very elderly patients (2011)
  • Author(s): Takahata O, Sasakawa T, Inagaki Y, Nagashima M, Iwasaki H
  • Organizer: Anesthesiology 2011
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-10-16
• [Presentation] Evaluation of repeated clinical dosing of rocuronium after reversal of neuromuscular block by sugammadex within a short time in four re-surgical patients (2011)
  • Author(s): Iwasaki H
  • Organizer: Annual Meeting American Society of Anesthesiologists
  • Place of Presentation: シカゴ
  • Year and Date: 2011-10-15
• [Presentation] Evaluation of short-term anesthetic induction with antecedent administration of remifentanil (2010)
  • Author(s): Kunisawa T
  • Organizer: Annual Meeting American Society of Anesthesiologists
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18
• [Presentation] Comparison of the Validity of Cp and Ce during Repeated Bolus Administration of Rocuronium (2010)
  • Author(s): Sasakawa T
  • Organizer: Annual Meeting American Society of Anesthesiologists
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18
• [Presentation] Intraosseous administration of rocuronium is equivalent route of intravenous (2010)
  • Author(s): Inagaki Y
  • Organizer: Annual Meeting American Society of Anesthesiologists
  • Place of Presentation: サンディエゴ
  • Year and Date: 2010-10-18
• [Book] 麻酔科学レクチャーここがポイント!気道確保Q & A誤嚥の危険性の高い症例 (2009)
  • Author(s): 高畑治
  • Publisher: 総合医学社
• [Book] JSAリフレッシャーコース2007レミフェンタニルの使い方教えます (2009)
  • Author(s): 高畑治
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] 麻酔科学レクチャー麻酔の現況と展望筋弛緩薬 (2009)
  • Author(s): 高畑治
  • Publisher: 総合医学社