Role of endogenous prostanoids in vascular remodeling
| Project/Area Number |
21591993
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Asahikawa Medical College |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | 内因性プロスタノイド / 血管リモデリング / プロスタノイド / 血管平滑筋 / リモデリング / 血管平滑筋細胞 |
|---|
| Research Abstract |
The intimal areas and medial areas two weeks after ligation of left common carotid arteries increased in both wild-type (WT) and EP4 receptor knockout (EP4^<-/->) mice. The intimal area four weeks after ligation was significantly increased in the ligated WT arteries compared with EP4^<-/-> arteries. I/M ratio and stenotic ration four weeks after blood flow cessation were also significantly increased in the ligated WT arteries compared with EP4^<-/->arteries. These results indicate that endogenous PGE2 plays an important role in intimal hyperplasia caused by blood-flow cessation via EP4 receptor.
|
Report
(4 results)
Research Products
(50 results)
