| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The purpose of this study was to examine the role of NF-κB and AP-1 during septic encephalopathy. After the establishment of septic shock using cecal ligation and puncture rat model, brain was removed. Brain slices were examined by ABC methods. The expression of NF-κB and AP-1 was highly observed in CA-1 region in hippocampus. In addition, response to noxious stimulation was also diminished at the same time. This data indicated that over expression of NF-κB and AP-1 in CA-1 region in hippocampus may have one of important role in the pathogenesis of septic encephalopathy.
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