the role of intercellular factor in the brain during septic encephalopathy and establishment of the treatment for septic encephalopathy
Project/Area Number |
21591998
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Gunma University |
Principal Investigator |
KADOI Yuji 群馬大学, 医学部, 准教授 (10292591)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 敗血症 / 脳障害 / 海馬 / 中枢神経障害 / NF-κB / AP-1 / hippocumpus CA1 / パッチクランプ / NF-κB発現 |
Research Abstract |
The purpose of this study was to examine the role of NF-κB and AP-1 during septic encephalopathy. After the establishment of septic shock using cecal ligation and puncture rat model, brain was removed. Brain slices were examined by ABC methods. The expression of NF-κB and AP-1 was highly observed in CA-1 region in hippocampus. In addition, response to noxious stimulation was also diminished at the same time. This data indicated that over expression of NF-κB and AP-1 in CA-1 region in hippocampus may have one of important role in the pathogenesis of septic encephalopathy.
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Report
(4 results)
Research Products
(28 results)