Effects of septic condition on pacemaking cell.-Anti-arrhythmic strategy by gene-based treatments-

• Project/Area Number: 21592001
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Aichi Medical University (2011); University of Toyama (2009-2010)
• Principal Investigator: HATAKEYAMA Noboru 愛知医科大学, 医学部, 教授 (70251907)
• Co-Investigator(Renkei-kenkyūsha): AOKI Yuta 富山大学, 大学病院, 助教 (10621667) ; KINOSHITA Hiroyuki 愛知医科大学, 医学部, 教授 (70291490) ; YAMAMOTO Seiji 富山大学, 大学院・医学薬学研究部, 助教 (10456361)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 敗血症 / 不整脈 / イオンチャネル / 全身性炎症反応症候群 / 心筋 / 活動電位 / チャネル発現 / カルシウムチャネル / カリウムチャネル / 全身性炎症症候群 / 頻脈性不整脈 / ショック / 心房筋

Research Abstract

In atrial myocytes from septic model of guinea pig, duration of action potential was significantly shortened. This may be the result of the nitration of the ion channels that would alter channel functions rather than the changes in atrial expression of the channels. The reduction of action potential duration could play a role for the development of atrial tachyarrhythmia in sepsis.

Research Products

• [Journal Article] Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs (2012)
  • Author(s): Aoki Y, Hatakeyama N, Yamamoto S, Kinoshita H, Matsuda N, Hattori Y, Yamazaki M
  • Journal Title: Br J Pharmacol Volume: 166 Issue: 1 Pages: 390-400
  • DOI: 10.1111/j.1476-5381.2011.01769.x
  • Peer Reviewed
• [Journal Article] le of ion channels in sepsis-induced atrial tachyarrhythmia in guinea pi (2012)
  • Author(s): uta Aoki, Noboru Hatakeyama, et al
  • Journal Title: British Journal of Pharmacology Volume: 166 Pages: 390-400
  • Peer Reviewed
• [Journal Article] 周術期不整脈の管理と治療全身性炎症反応症候群(SIRS)と頻脈性不整脈、その治療戦略 (2010)
  • Author(s): 畠山登, 青木優太, 木下浩之, 寺前洋生, 松田直之, 山崎光章
  • Journal Title: 日本臨床麻酔学会誌 Volume: 30巻5号 Pages: 765-770
• [Journal Article] 全身性炎症反応症候群(SIRS)と頻脈性不整脈,その治療戦略 (2010)
  • Author(s): 畠山登
  • Journal Title: 日臨麻会誌 Volume: 30 Pages: 765-770
  • NAID: 10026629715
• [Journal Article] Pharmacological significance of the blocking action of the intravenous general anesthetic propofol on the slow component of cardiac delayed rectifier K+current (2009)
  • Author(s): Hatakeyama N, Sakuraya F, Matsuda N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y
  • Journal Title: J Pharmacol Sci. 2009 Jul Volume: 110(3) Pages: 334-43
  • NAID: 10025737753
• [Journal Article] 敗血症性ショックにおけるアポトーシスの治療 (2009)
  • Author(s): 松田直之, 山本誠士, 寺前洋生, 高野健一, 別府賢, 山崎弘美, 横尾宏毅, 畠山登, 小池薫, 服部裕一
  • Journal Title: 日本薬理学雑誌 Volume: 134巻4号 Pages: 198-201
  • NAID: 10025741693
• [Journal Article] Pharmacological significance of the blocking action of the intravenous general an esthetic propofol on the slow component of cardiac delayed rectifier K+ current. (2009)
  • Author(s): Hatakeyama N, Sakuraya F, Matsud a N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y.
  • Journal Title: J Pharmacol Sci 110 Pages: 334-343
  • Peer Reviewed
• [Journal Article] 敗血症性ショックにおけるアポトーシスの治療 (2009)
  • Author(s): 松田直之, 山本誠士, 寺前洋生, 高野健一, 別府賢, 山崎弘美, 横尾宏毅, 畠山登, 小池薫, 服部裕一
  • Journal Title: 日本薬理学雑誌 134 Pages: 198-201
  • NAID: 10025741693
  • Peer Reviewed
• [Presentation] Modulation of Potassium Channel Plays a Role for Septic Tachyarrhythmia (2011)
  • Author(s): Noboru Hatakeyama
  • Organizer: 2011 ASA Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2011-10-15
• [Presentation] Modulation on Expression and Function of Calcium and Potassium Channels in Septic Guinea Pig Atrium (2011)
  • Author(s): Hatakeyama N.
  • Organizer: Society of critical Care Medicine 40th Critical Care Congress
  • Place of Presentation: San Diego, U. S. A.
• [Presentation] Modulation of Potassium Channel Plays a Role for Septic Tachyarrhythmia (2011)
  • Author(s): Hatakeyama N.
  • Organizer: 2011 Annual Meeting of the American Society Anesthesiologists
  • Place of Presentation: Chicago, U. S. A.
• [Presentation] Modulation on Expression and Function of Calcium and Potassium Channels in Septic Guinea Pig Atrium. (2011)
  • Author(s): 畠山登
  • Organizer: SCCM 40^<th> Critical Care Congress
  • Place of Presentation: San Diego, USA
• [Presentation] Sepsis-Induced Modulation of Ion Channels and the Role of Protein Nitrosylation in Atrial Myocytes. (2010)
  • Author(s): 畠山登
  • Organizer: 2010 ASA Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-20
• [Presentation] 全身性炎症反応症候群・敗血症と急性腎障害 (2010)
  • Author(s): 畠山登
  • Organizer: 日本心臓血管麻酔学会第15回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-10
• [Presentation] 酸化ストレスによるモルモット心室筋活動電位変化とプロポフォールによる影響についての検討 (2010)
  • Author(s): 畠山登
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2010-06-04
• [Presentation] Tachyarrhythmia in sepsis is attributable to both the inhibition of calcium channel expression and nitrotyrosilation of calcium channel (2010)
  • Author(s): Hatakeyama N.
  • Organizer: Society of critical Care Medicine 39th Critical Care Congress
  • Place of Presentation: Miami Beach, U. S. A.
• [Presentation] 敗血症時の頻脈性不整脈発生機序に対するnitrotyrosylationの影響 (2010)
  • Author(s): 畠山登
  • Organizer: 第31回循環制御医学会総会
  • Place of Presentation: 大阪
• [Presentation] 敗血症モルモットにおける心房筋カルシウムチャネル変化の検討 (2010)
  • Author(s): 畠山登
  • Organizer: 第31回循環制御医学会総会
  • Place of Presentation: 大阪
• [Presentation] 敗血症モルモット心房筋カルシウムチャネル発現および機能の変化 (2010)
  • Author(s): 畠山登
  • Organizer: 日本麻酔科学会第57回学術集会
  • Place of Presentation: 福岡
• [Presentation] Effect of Hydrogen Peroxide on Action Potential and the Protection by Propofol in Cardiac Myocytes (2010)
  • Author(s): Hatakeyama N
  • Organizer: 2010 Annual Meeting of the American Society Anesthesiologists
  • Place of Presentation: San Diego, U. S. A.
• [Presentation] 敗血症時の頻脈性不整脈における心房筋イオンチャネル発現と機能の変化 (2009)
  • Author(s): 畠山登
  • Organizer: 日本麻酔科学会 第56回学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-08-18
• [Presentation] 敗血症時の頻脈性不整脈発生機序に対するnitrotyrosylationの影響 (2009)
  • Author(s): 畠山登
  • Organizer: 第30回日本循環制御医学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 敗血症時の頻脈性不整脈における心房筋イオンチャネル発現と機能の変化 (2009)
  • Author(s): 畠山登
  • Organizer: 社団法人日本麻酔科学会第56回学術集会
  • Place of Presentation: 神戸
• [Presentation] 全身性炎症反応症候群(SIRS)と頻脈性不整脈,その治療戦略 (2009)
  • Author(s): 畠山登
  • Organizer: 日本臨床麻酔学会第29回大会
  • Place of Presentation: 浜松
• [Book] カテコラミンの使い方Pros & Cons.救急・ERノート2 (2011)
  • Author(s): 畠山登
  • Publisher: 羊土社