Effects of septic condition on pacemaking cell.-Anti-arrhythmic strategy by gene-based treatments-
| Project/Area Number |
21592001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Aichi Medical University (2011)
University of Toyama (2009-2010) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
AOKI Yuta 富山大学, 大学病院, 助教 (10621667)
KINOSHITA Hiroyuki 愛知医科大学, 医学部, 教授 (70291490)
YAMAMOTO Seiji 富山大学, 大学院・医学薬学研究部, 助教 (10456361)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 敗血症 / 不整脈 / イオンチャネル / 全身性炎症反応症候群 / 心筋 / 活動電位 / チャネル発現 / カルシウムチャネル / カリウムチャネル / 全身性炎症症候群 / 頻脈性不整脈 / ショック / 心房筋 |
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| Research Abstract |
In atrial myocytes from septic model of guinea pig, duration of action potential was significantly shortened. This may be the result of the nitration of the ion channels that would alter channel functions rather than the changes in atrial expression of the channels. The reduction of action potential duration could play a role for the development of atrial tachyarrhythmia in sepsis.
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Report
(4 results)
Research Products
(25 results)
