| Project/Area Number |
21592007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
|
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| Research Institution | Osaka University |
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Principal Investigator |
FUJINO Yuji 大阪大学, 医学系・研究科, 講師 (50252672)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHTA Noriyuki 大阪大学, 医学部附属病院, 助教 (60379162)
HIRAO Osamu 大阪大学, 医学部附属病院, 助教 (10362617)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 急性肺傷害 / 人工呼吸器 / 自発呼吸骨髄由来樹状細胞 / Th1型免疫応答 / 鎮静薬ミダゾラム / 人工呼吸 / 肺保護戦略 / 自発呼吸 / 樹状細胞 / 炎症 / サイトカイン / 細胞分化 / プロポフォール / 脂肪細胞 / ストローマ細胞 |
|---|
| Research Abstract |
Midazolam inhibits the functional maturation of murine DCs and interferes with DC induction of T helper 1 immunity in the whole mouse. Further, by the use of rabbit model of acute lung injurty, we elucidated the role of maintaining spontaneous breathing for the progression of acute lung injury. Even in the lung-protective strategy for acute lung injury, the inadequate maintenance of spontaneous ventilation can make clinical outcome worse.
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