• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapy for acute lung injury by adipose-tissue derived stromal cells

Research Project

Project/Area Number 21592007
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionOsaka University

Principal Investigator

FUJINO Yuji  大阪大学, 医学系・研究科, 講師 (50252672)

Co-Investigator(Kenkyū-buntansha) OHTA Noriyuki  大阪大学, 医学部附属病院, 助教 (60379162)
HIRAO Osamu  大阪大学, 医学部附属病院, 助教 (10362617)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords急性肺傷害 / 人工呼吸器 / 自発呼吸骨髄由来樹状細胞 / Th1型免疫応答 / 鎮静薬ミダゾラム / 人工呼吸 / 肺保護戦略 / 自発呼吸 / 樹状細胞 / 炎症 / サイトカイン / 細胞分化 / プロポフォール / 脂肪細胞 / ストローマ細胞
Research Abstract

Midazolam inhibits the functional maturation of murine DCs and interferes with DC induction of T helper 1 immunity in the whole mouse. Further, by the use of rabbit model of acute lung injurty, we elucidated the role of maintaining spontaneous breathing for the progression of acute lung injury. Even in the lung-protective strategy for acute lung injury, the inadequate maintenance of spontaneous ventilation can make clinical outcome worse.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (10 results)

  • [Journal Article] Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model : high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury2012

    • Author(s)
      Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y
    • Journal Title

      Crit Care Med

      Volume: 40 Pages: 1578-85

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneous breathing during lung protective ventilation in experimental acute lung injury model : high transpulmonary pressure associated with strong spontaneous breathing effort may worsen lung injury2012

    • Author(s)
      藤野裕士
    • Journal Title

      Critical Care Medicine

      Volume: (掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming of lipopolysaccharide-induced T helper 1-type immune response2011

    • Author(s)
      Ohta N, Ohashi Y, Takayama C, Mashimo T, Fujino Y
    • Journal Title

      Anesthesiology

      Volume: 114 Pages: 355-62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effect of ventilator performance on airway pressure release ventilation : a model lung study2011

    • Author(s)
      Yoshida T, Uchiyama A, Mashimo T, Fujino Y
    • Journal Title

      Anesth Analg

      Volume: 113 Pages: 529-33

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming oflipopolysaccharide-induced T helper-1 type immune response2011

    • Author(s)
      大田典之, 藤野裕士
    • Journal Title

      Anesthesiology

      Volume: 114 Pages: 355-362

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of ventilator performanxe on airway pressure release ventilation : alung model study2011

    • Author(s)
      藤野裕士
    • Journal Title

      Anesthesia and Analgesia

      Volume: 113 Pages: 529-533

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Midazolam suppresses maturation of murine dendritic cells and priming of lipopolysaccharide-induced t helper 1-type immune response2011

    • Author(s)
      大田典之、藤野裕士
    • Journal Title

      Anesthesiology.

      Volume: 114 Pages: 355-62

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Propofol has anti-inflammatory effects on alveolar type II epithelial cells2010

    • Author(s)
      馬鈴、藤野裕士
    • Journal Title

      Acta Anaesthesiol Scand.

      Volume: 54 Pages: 362-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of performance of two high-frequency oscillatory ventilators using a model lung with a position sensor.2010

    • Author(s)
      井口直也、藤野裕士
    • Journal Title

      J Anesth

      Volume: 24 Pages: 888-92

    • NAID

      10027741404

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of continuous venovenous hemofiltration on the pharmacology of carperitide, a recombinant human atrial natriuretic peptide2010

    • Author(s)
      高橋りょう子、藤野裕士
    • Journal Title

      Circ J

      Volume: 74 Pages: 1888-92

    • NAID

      10026971432

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ketamine inhibits maturation of bone marrow-derived dendritic cells and priming of the Th1-type immune response2009

    • Author(s)
      Ohta N, Ohashi Y, Fujino Y
    • Journal Title

      Anesth Analg

      Volume: 109 Pages: 793-800

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ketamine inhibits maturation of bone marrow-derived dendritic cells and priming of the Th1-type immune response2009

    • Author(s)
      大田典之, 藤野裕士
    • Journal Title

      Anesthesia and Analgeisa 109

      Pages: 793-800

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury2009

    • Author(s)
      藤野裕士, 大田典之
    • Journal Title

      Med Sci Monit 15

      Pages: 207-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An expiratory assist during spontaneous breathing can compensate for endotracheal tube resistance2009

    • Author(s)
      藤野裕士
    • Journal Title

      Anesthesia and Analgeisa 109

      Pages: 34-40

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 敗血症は粘膜免疫応答を低下させる2012

    • Author(s)
      大田典之、山中秀則、高山千尋、後藤幸子、井口直也、平松大介、真下節、藤野裕士
    • Organizer
      第39回日本集中治療医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-01
    • Related Report
      2011 Final Research Report
  • [Presentation] プロポフォールは樹状細胞によって惹起されるTh1型免疫応答を促進する2012

    • Author(s)
      山中秀則、大田典之、高山千尋、後藤幸子、井口直也、平松大介、真下節、藤野裕士
    • Organizer
      第39回日本集中治療医学会学術総会
    • Place of Presentation
      千葉
    • Year and Date
      2012-03-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 敗血症は粘膜免疫応答を低下させる2012

    • Author(s)
      大田典之, 藤野裕士
    • Organizer
      日本集中治療医学会総会
    • Place of Presentation
      幕張(千葉)
    • Year and Date
      2012-03-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロポフォールは樹状細胞によって惹起されるTh1型免疫応答を増強する2012

    • Author(s)
      大田典之, 藤野裕士
    • Organizer
      日本集中治療医学会総会
    • Place of Presentation
      幕張(千葉)`
    • Year and Date
      2012-03-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 樹状細胞の機能に対する鎮静薬の影響の多様性2011

    • Author(s)
      大田典之、山中秀則、高山千尋、後藤幸子、井口直也、平松大介、内山昭則、藤野裕士
    • Organizer
      第38回日本集中治療医学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2011-02-26
    • Related Report
      2011 Final Research Report
  • [Presentation] ARDS/ALIの管理2011

    • Author(s)
      藤野裕士
    • Organizer
      第38回日本集中治療医学会学術集会
    • Place of Presentation
      横浜(招待講演)
    • Year and Date
      2011-02-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミダゾラムは樹状細胞によって惹起されるTh1型の免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      日本麻酔科学会第57回学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2010-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ミダゾラムは樹状細胞によって惹起されるTh1型の免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      日本麻酔科学会 第57回学術集会
    • Place of Presentation
      福岡(招待講演)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床使用濃度のミダゾラムは樹状細胞によって起こるTh1型免疫応答を抑制する2010

    • Author(s)
      大田典之、井口直也、植田一吉、平尾収、後藤幸子、内山昭則、高山千尋、藤野裕士
    • Organizer
      第37回日本集中治療医学会学術総会
    • Place of Presentation
      広島
    • Year and Date
      2010-03-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 臨床使用濃度のミダゾラムは樹状細胞によって惹起されるTh1型免疫応答を抑制する2010

    • Author(s)
      大田典之
    • Organizer
      日本集中治療医学会
    • Place of Presentation
      広島市
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi