Basic research of pain control by DNA decoy for brain-derived neurotrophic factor
| Project/Area Number |
21592008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kochi University |
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Principal Investigator |
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| Research Collaborator |
OBATA Norihiko 岡山大学, 病院, 助教
MATSUOKA Yoshikazu 岡山大学, 病院, 助教
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 神経障害性痛 / 脳由来神経栄養因子 / エクソン / DNAデコイ / 遺伝子療法 / 疼痛 |
|---|
| Research Abstract |
We made DNA decoy for brain-derived neurotrophic factor(BDNF) exon-1 that is increased significantly in the spinal level of neuropathic pain model. We administered DNA decoy intrathecally to knock-down BDNF exon-1 in pain model rats, and confirmed that pain response was decreased by DNA decoy.
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Report
(4 results)
Research Products
(51 results)
