| Project/Area Number |
21592010
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MORITA Kiyoshi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40108171)
MORIMATSU Hiroshi 岡山大学, 岡山大学病院, 講師 (30379797)
TAKAHASHI Toru 岡山大学, 岡山大学病院, 助教 (40252952)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 周術期管理 / 肝臓移植 / 虚血再潅流障害 / 一酸化炭素 / Heme oxygenase-1 / ヘモオキシゲナーゼ / 肝移植 / 再環流障害 / 虚血再環流 / 酸化ストレス / 呼気ガス / ヘムオキシゲナーゼ-1 / 生体肝移植 / ストレス蛋白 / 貴伝子発現 |
|---|
| Research Abstract |
During living donor liver transplantation, several changes would be happen after ishcemia/reperfusion. Nowadyas, there is no definite indicator of these changes. Therefore, we examined whether exhaled carbon monoxide(CO) concentration would be the indicator of these changes during liver transplantation. As the results, we found that exhaled CO concentration had a correlation with intra-hepatic heme oxygenase-1 gene expression and protein expression as well. This result indicated that exhaled CO concentration would be a novel therapeutic marker of ishcemia/reperfusion injury.
|
