Evaluation of the anti-tumor effect of microRNA on cancer metastasis under the general anesthesia

• Project/Area Number: 21592014
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kyushu University
• Principal Investigator: SHINICHIRO Yoshitake 九州大学, 大学病院, 講師 (80315142)
• Co-Investigator(Kenkyū-buntansha): ISHII Hideshi 大阪大学, 医学系研究科, 寄付講座教授 (10280736) ; 三森 功士 九州大学, 生体防御医学研究所, 准教授 (50322748)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: microRNA / 骨髄 / 転移 / 再発 / ヒストンファミリー / Histone / 骨髄細胞 / 胃癌 / 全身麻酔 / 全身麻酔薬 / マイクロRNA / 微量癌細胞 / マイクロアレイ

Research Abstract

Under the general anesthesia, host cells in bone marrow(BM) might play a consecutive role in recurrence or metastasis in gastric cancer(GC) cases. We have focused on gene/miR axis in host cells and compared the gene/miR axis in BM between from stage IV and stage I GC cases. Then, we identified significant 106 gene/miR axis and found that HIST family/miR760 axis was the most clinical significant one in GC cases among them. Therefore, we will evaluate the magnitude of the level of miR/gene axis on the cancer metastasis affected by general anesthesia.

Research Products

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• [Journal Article] MicroRNA-372 Is Associated with Poor Prognosis in Colorectal Cancer (2012)
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• [Journal Article] Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24 (2012)
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• [Journal Article] MicroRNA-10b is a Prognostic Indicator in Colorectal Cancer and Confers Resistance to the Chemotherapeutic Agent 5-Fluorouracil in Colorectal Cancer Cells (2012)
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• [Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance (2012)
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• [Journal Article] Hypoxia and TP53 deficiency for induced pluripotent stem cell-like properties in gastrointestinal cancer (2012)
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• [Journal Article] Reprogramming of gastrointestinal cancer cells (2012)
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• [Journal Article] Absence of CD71 transferrin receptor characterizes human gastric adenosquamous carcinoma stem cells (2012)
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• [Journal Article] Microarray Analysis of Colorectal Cancer Stromal Tissue Reveals Upregulation of Two Oncogenic miRNA Clusters (2012)
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• [Journal Article] Cancer stem cell (2011)
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• [Journal Article] Molecular biology of colon cancer (2011)
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• [Journal Article] Cancer stem cell theory in gastrointestinal malignancies : recent progress and upcoming challenges (2011)
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• [Journal Article] Expression of CLDN1 in colorectal cancer (2011)
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• [Journal Article] Reprogramming of mouse and human cells to pluripotency using mature microRNAs (2011)
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• [Journal Article] MicroRNA miR-125b is a prognostic marker in human colorectal cancer' (2011)
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• [Journal Article] Combination use of anti-CD133 antibody and SSA lectin can effectively enrich cells with high tumorigenicity (2011)
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• [Journal Article] The future prospects and subject of the liver cancer stem cells study for the clinical application (2011)
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• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
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• [Journal Article] Significance of Lgr5(+ ve) cancer stem cells in the colon and rectum (2011)
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• [Journal Article] Significance of Lgr5(+ ve) cancer stem (2011)
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• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal SquamousCell Carcinoma (2011)
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• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2011)
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• [Journal Article] Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs (2011)
  • Author(s): Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL,Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M
  • Journal Title: Cell Stem Cell Volume: 8 Issue: 6 Pages: 633-8
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• [Journal Article] The Significance of PTTX2 Overexpression in Human Colorectal Cancer (2011)
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• [Journal Article] Clinical Significance of Circulating Tumor Cells, Including Cancer Stem-Like Cells, in Peripheral Blood for Recurrence and Prognosis in Patients With Dukes' Stage B and C Colorectal Cancer (2011)
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• [Journal Article] Identification of HLA-A*0201/-A*2402-restricted CTL epitope-peptides derived from a novel cancer/testis antigen, MCAK, and induction of a specific antitumor immune response (2011)
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• [Journal Article] STC2 : a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma (2011)
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• [Journal Article] The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events (2011)
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  • Journal Title: Aging Male Volume: 14 Pages: 21-6
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• [Journal Article] The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes (2011)
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• [Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression (2011)
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• [Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab (2011)
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• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (2011)
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• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients (2011)
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• [Journal Article] Significance of Lgr5(+ve) Cancer Stem Cells in the Colon and Rectum (2011)
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• [Journal Article] Hypoxia-inducible Adrenomedullin in Colorectal Cancer (2011)
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• [Journal Article] Identification of recurrence-related microRNAs in the bone marrow of breast cancer patients. (2010)
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• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells (2010)
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• [Journal Article] Long-term culture following ES-like gene-induced reprogramming elicits an aggressive phenotype in mutated cholangiocellular carcinoma cells (2010)
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• [Journal Article] The clinical significance of vimentin-expressing gastric cancer cells in bone marrow (2010)
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• [Journal Article] Risk factors for postoperative delirium in elderly patients with colorectal cancer (2010)
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• [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer (2010)
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• [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorectal cancer (2010)
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• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer (2010)
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• [Journal Article] TGM2 Is a Novel Marker for Prognosis and Therapeutic Target in Colorectal Cancer (2010)
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  • DOI: 10.1245/s10434-009-0865-y
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi N, Ishii H, Nagai KI, Hoshino H, Mimori K, Tanaka F, Nagano H, Sekimoto M, Doki Y, Mori M.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107(1) Issue: 1 Pages: 40-5
  • DOI: 10.1073/pnas.0912407107
• [Journal Article] CD13 is a therapeutic target in human liver cancer stem cells. (2010)
  • Author(s): Haraguchi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: J Clin Invest Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] Notch pathway as candidate therapeutic target in Her2/Neu/ErbB2 receptor-negative breast tumors (2010)
  • Author(s): Hirose, H., Ishii, H., Mimor, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 35-43
  • Peer Reviewed
• [Journal Article] Clinical Significance of Human Kallikrein7 Gene Expression in Colorectal Cancer. (2010)
  • Author(s): Inoue, Y., Yokobori, T., Yokoe, T., Toiyama, Y., Miki, C., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] The Clinical Significance of Vimentin-Expressing Gastric Cancer Cells in Bone Marrow (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] Overexpression of SUGT1 in human colorectal cancer and its clinicopathological significance (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 569-75
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition in cancer development and its clinical significance (2010)
  • Author(s): Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 293-9
  • Peer Reviewed
• [Journal Article] STC2 : A Predictive Marker for Lymph Node Metastasis in Esophageal Squamous-Cell Carcinoma (2010)
  • Author(s): Kita, Y., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Pages: 4-4
  • Peer Reviewed
• [Journal Article] Expression of C4.4A at the invasive front is a novel prognostic marker for disease recurrence of colorectal cancer (2010)
  • Author(s): Konishi, K., Yamamoto, H., Mimori, K., et al.
  • Journal Title: Cancer Sci Volume: 101 Pages: 2269-77
  • Peer Reviewed
• [Journal Article] FHIT Suppresses Inflammatory Carcinogenic Activity by Inducing Apoptosis in Esophageal Epithelial Cells (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: J Nucleic Acid Invest Volume: 101 Pages: 2269-77
  • Peer Reviewed
• [Journal Article] Serum Matrix-Metalloproteinase-1 is a Bona Fide Prognostic Marker for Colorectal Cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] Abnormal Expression of PFDN4 in Colorectal Cancer : A Novel Marker for Prognosis (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] TDGF1 is a novel predictive marker for metachronous metastasis of colorectal cancer (2010)
  • Author(s): Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 563-8
  • Peer Reviewed
• [Journal Article] SCRN1 is a novel marker for prognosis in colorectal cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: J Surg Oncol Volume: 101 Pages: 156-9
  • Peer Reviewed
• [Journal Article] TGM2 is a novel marker for prognosis and therapeutic target in colorectal cancer (2010)
  • Author(s): Miyoshi, N., Ishiii, H., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 967-72
  • Peer Reviewed
• [Journal Article] ATP11A is a novel predictive marker for metachronous metastasis of colorctal cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Oncol Rep Volume: 23 Pages: 505-10
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 107 Pages: 40-5
  • Peer Reviewed
• [Journal Article] Clinicopathological and prognostic significance of PDCD4 and microRNA-21 in human gastric cancer (2010)
  • Author(s): Miyoshi, N., Ishii, H., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 36 Pages: 1089-95
  • Peer Reviewed
• [Journal Article] Correlated expression of CD47 and SIRPA in bone marrow and in peripheral blood predicts recurrence in breast cancer patients (2010)
  • Author(s): Nagahara, M., Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4625-35
  • Peer Reviewed
• [Journal Article] FOXC2 is a Novel Prognostic Factor in Human Esophageal Squamous Cell Carcinoma (2010)
  • Author(s): Nishida, N., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] FANCD2 mRNA overexpression is a bona fide indicator of lymph node metastasis in human colorectal cancer (2010)
  • Author(s): Ozawa, H., Iwatsuki, M., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 2341-8
  • Peer Reviewed
• [Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles (2010)
  • Author(s): Tanaka, F., Yamamoto, K., Suzuki, S., Inoue, H., Tsurumaru, M., Kajiyama, Y., Kato, H., Igaki, H., Furuta, K., Fujita, H., Tanaka, T., Tanaka, Y., Kawashima, Y., Natsugoe, S., Setoyama, T., Tokudome, S., Mimori, K., et al.
  • Journal Title: Gut Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] Clinical significance of ASB9 in human colorectal cancer (2010)
  • Author(s): Tokuoka, M., Miyoshi, N, Hitora, T., Mimori, K., et al.
  • Journal Title: Int J Oncol Volume: 37 Pages: 1105-11
  • Peer Reviewed
• [Journal Article] Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer : in vivo identification from hypoxic tumor cells (2010)
  • Author(s): Uemura, M., Yamamoto, H., Takemasa, I., Mimori, K., et al.
  • Journal Title: Clin Cancer Res Volume: 16 Pages: 4636-46
  • Peer Reviewed
• [Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer (2010)
  • Author(s): Yokobori, T., Mimori, K., et al.
  • Journal Title: Ann Surg Oncol Volume: (CD-R)
  • Peer Reviewed
• [Journal Article] Defined factors induce reprogramming of gastrointestinal cancer cells (2010)
  • Author(s): Miyosi N., Mimori K., et al.
  • Journal Title: Proc Natl Acad Sci.(USA) 107 Pages: 40-5
  • Peer Reviewed
• [Journal Article] p53-Altered FBXW7 expression determines poor prognosis in gastric cancer cases (2009)
  • Author(s): Yokobori T., Mimori K., et al.
  • Journal Title: Cancer Res 69 Pages: 3788-94
  • Peer Reviewed
• [Journal Article] Preoperative u-PAR gene expression in bone marrow indicates the potential power of recurrence in breast cancer cases (2009)
  • Author(s): Mimori K., et al
  • Journal Title: Ann Surg Oncol 16 Pages: 2035-41
  • Peer Reviewed
• [Presentation] 食道癌における転移関連遺伝子FOXC2の臨床病理学的意義 (2011)
  • Author(s): 西田尚弘、三森功士、澤田元太、高橋佑典、古後龍之介、赤木智徳、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第70回日本癌学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] ゲノム解析から選択されたADH1BまたはALDH2遺伝子多型と食道扁平上皮癌罹患:飲酒と喫煙との相互関係 (2011)
  • Author(s): 田中文明、井上裕、石丸神矢、西田尚弘、岩谷岳、主藤朝也、柴田浩平、三森功士、石井秀始、森正樹
  • Organizer: 日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-13
• [Presentation] 大腸癌間質におけるマイクロRNA-遺伝子pathwayの包括的解析 (2011)
  • Author(s): 西田尚弘、永原誠、三森功士、古後龍之介、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第20回日本がん転移学会
  • Place of Presentation: 浜松
  • Year and Date: 2011-06-30
• [Presentation] ゲノム解析から選択されたADH1BまたはALDH2遺伝子多型は、飲酒と喫煙により食道扁平上皮癌罹患に強く相関する (2011)
  • Author(s): 田中文明、井上裕、石丸神矢、西田尚弘、岩谷岳、古後龍之介、主藤朝也、柴田浩平、三森功士、石井秀始、森正樹
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (紙面開催)
  • Year and Date: 2011-05-26
• [Presentation] Gastrointestinal Cancer Stem Cells. (2011)
  • Author(s): 石井秀始、原口直紹、竹政伊知朗、水島恒和、池田正孝、山本浩文、永野浩昭、関本貢嗣、土岐祐一郎、森正樹
  • Organizer: 第111回日本外科学会
  • Place of Presentation: 紙上開催
• [Presentation] 胃癌におけるマイクロRNAmiR-125aの臨床病理学的意義 (2011)
  • Author(s): 西田尚弘、三森功士、古後龍之介、石丸神矢、岩谷岳、主藤朝也、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第66回日本消化器外科学会
  • Place of Presentation: 名古屋
• [Presentation] 消化器の癌肝細胞 (2010)
  • Author(s): 石井秀始、原口直紹、関本貢嗣、永野浩昭、土岐祐一郎、森正樹
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 臨床病理学的診断を凌駕する、マイクロアレイを用いたDukes B大腸癌における転移予測因子の同定 (2010)
  • Author(s): 三森功士、横堀武彦、飯沼久恵、石井秀始、クラウス・パンテル、森正樹
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] (2010)
  • Author(s): 田中文明、山本健、鈴木貞夫、井上裕、主藤朝也、三森功士、柴田浩平、石井秀始、森正樹
  • Organizer: 第64回日本食道学会
  • Place of Presentation: 久留米
  • Year and Date: 2010-09-01
• [Presentation] 大腸癌細胞のゲノムCGHクラスター解析および発現アレイpathway解析による5-FU適応症例の決定 (2010)
  • Author(s): 三森功士, 他8名
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-09
• [Presentation] (2010)
  • Author(s): 西田尚弘、三森功士、横堀武彦、岩槻政晃、田中文明、柴田浩平、石井秀始、森正樹
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] Identification of target gene enhanced by Wnt/TCF binding to the predisposition SNP rs6983267 at chromosome 8q24 in colorectal cancer cases (2010)
  • Author(s): Mimori K., et al
  • Organizer: Society of Surgical Oncology, 2010
  • Place of Presentation: St.Loius
  • Year and Date: 2010-03-05
• [Presentation] 大腸癌におけるCD133発現と関連する遺伝子の解析:新規癌肝細胞マーカーの可能性 (2009)
  • Author(s): 秋吉清百合、三森功士、原口直紹、石井秀始、森正樹
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 新規EMT誘導遺伝子Xの大腸癌臨床的意義とX導入CD133発現大腸癌細胞における造腫瘍形成能 (2009)
  • Author(s): 三森功士、横堀武彦、石井秀始、森正樹
  • Organizer: 第68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] 大腸癌におけるEMTを制御し造腫瘍能と他文化能を有する遺伝子の臨床的意義と機能解析 (2009)
  • Author(s): 三森功士、横堀武彦、岩槻政晃、石丸神矢、秋吉清百合、永原誠、石井秀始、森正樹
  • Organizer: 第18回日本がん転移学会
  • Place of Presentation: 旭川
  • Year and Date: 2009-07-23