| Project/Area Number |
21592015
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kansai University of Health Sciences (2010-2011)
Niigata University (2009) |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NAKATSUKA TERUMASA 関西医療大学, 保健医療学部, 教授 (30380752)
KOHNO Tatsuro 新潟大学, 医歯学系, 准教授 (00313536)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 疼痛管理学 / 脊髄後角 / spare nerve injury mode / グリア細胞 / グリシン受容体 / NMDA受容体 / D-serine / パッチクランプ / グリア由来伝達物質 / 神経障害性疼痛 / グリシントランスポーター / ブラインドパッチクランプ法 / アストロサイト / MAPK / Glycine受容体 |
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| Research Abstract |
We investigated the effect of glycine transporter in spinal dorsal horn neuron, but we could not find that effect. Therefore, we have demonstrated that d-serine in spinal dorsal horn neuron has two distinct actions, one is an excitatory action mediated by NMDA receptor, the other is an inhibitory action mediated by glycine receptor. Interestingly, the excitatory action by d-serine after peripheral nerve injury was more sensitive than physiological condition, whereas its inhibitory action after peripheral nerve injury was less than naive one.
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