Activation of Sensory Neurons Reduces Ischemia/Reperfusion-induced Acute Renal Injury in Type 2 Diabetes Rats

• Project/Area Number: 21592017
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Oita University
• Principal Investigator: KUDO Kyosuke 大分大学, 医学部, 助教 (80336271)
• Co-Investigator(Kenkyū-buntansha): NOGUCHI Takayuki 大分大学, 医学部, 教授 (90156183)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 2型糖尿 / CGRP / TNF-α / 知覚神経 / 腎虚血再灌流 / 糖尿病 / ダナパロイド / PGI2 / 血管内皮細胞 / カプサイシン / アンチトロンビン / 2型糖尿病

Research Abstract

The diabetes patient which characterized by hyperglycosemia, was recognized that it was easy to produce an organ injury compare with the normal condition. In this mechanism, it was suggested that the excessive reaction of various inflammatory mediators which were including cytokine, HMGB1 etc.