| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We tested the effects of human peptides during anesthesia and shock on human vascular smooth muscle and vital reactions. A novel a novel isoindolin-1-one derivate, JM1232(-), directly dilated human gastroepiploic arteries in vitro in clinical doses and this drug suppressed the heart rate and blood pressure of rat dose-dependent manner. In addition, as to the relationship between blood sugar and insulin susceptibility during anesthesia, we measured a biomarker for blood sugar control, 1. 5AG, in patients with general anesthesia.
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