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Evaluation of neuroendocrine in primary afferent neuron of neuropathic pain

Research Project

Project/Area Number 21592020
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionNagoya City University

Principal Investigator

SUGIURA Takeshi  名古屋市立大学, 大学院・医学研究科, 講師 (20295611)

Co-Investigator(Kenkyū-buntansha) SOBUE Kazuya  名古屋市立大学, 大学院・医学研究科, 教授 (90264738)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsパッチクランプ / 後根神経節 / 侵害受容器 / サーモグラフィー
Research Abstract

Behavior tests, which study on hypersensitivity to thermal stimulation, have indicated the effect of water in CCI model. Primary afferent neurons innervated to mouse hind-paw were labeled and discriminated by using DiI. Capsaicin sensitivity of hind-paw neurons suggested that TRPV1 might have relatively little contribution for nociception and neurogenic inflammation. Recently, TRPA1 inhibition was reported to reduce neurogenic inflammation, which suggests that TRPA1 might be involved in neuroendocrine in primary afferents.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (15 results)

  • [Journal Article] A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis2011

    • Author(s)
      Takayanagi T, Sasaki H, Kawashima A, Mizuochi Y, Hirate H, Sugiura T, Azami T, Asai K, Sobue K
    • Journal Title

      JPEN J Parenter Enteral Nutr

      Volume: 35(4) Pages: 516-22

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] プラミペキソールが有効であった有痛性下肢運動障害疾患の1症例2011

    • Author(s)
      杉浦健之、徐民恵、幸村英文, 平手博之, 藤田義人, 薊隆文、伊藤彰師、笹野寛, 祖父江和哉
    • Journal Title

      日本ペインクリニック学会誌

      Volume: 18(4) Pages: 384-387

    • NAID

      10029809632

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 巨大ブラを有する患者に対する自発呼吸下腕神経叢ブロック併用全身麻酔の経験2011

    • Author(s)
      杉浦健之、秋吉瑠美子、加藤利奈、笹野寛、祖父江和哉
    • Journal Title

      麻酔

      Volume: 60(9) Pages: 1101-1103

    • NAID

      40018967039

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide, protects against carbon tetrachloride-induced hepatitis2011

    • Author(s)
      杉浦健之、社父江和哉, ら
    • Journal Title

      J Parenter Enteral Nutr

      Volume: 35 Pages: 516-522

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] プラミペキソールが有効であった有痛性下肢運動障害疾患の1症例2011

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Journal Title

      日本ペインクリニック学会誌

      Volume: 18 Pages: 384-387

    • NAID

      10029809632

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 巨大ブラを有する患者に対する自発呼吸下腕神経叢ブロック併用全身麻酔の経験2011

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Journal Title

      麻酔

      Volume: 60 Pages: 1101-1103

    • NAID

      40018967039

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 水チャネル<アクアポリン>の中枢神経における多様な機能と関連疾患2010

    • Author(s)
      祖父江和哉, 高柳猛彦, 平手博之, 杉浦健之, 藤田義人, 浅井清文
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 38(2) Pages: 145-150

    • NAID

      10026404857

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anesthesia preoperative preparation of muscular dystrophy2010

    • Author(s)
      祖父江和哉, ら
    • Journal Title

      Masui

      Volume: 59 Pages: 1093-1095

    • NAID

      40017289315

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation before anesthesia for patients with myasthenia gravis2010

    • Author(s)
      祖父江和哉, ら
    • Journal Title

      Masui

      Volume: 59 Pages: 1089-1092

    • NAID

      40017289314

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal prediction of the central venous catheter insertion depth on a routine chest x-ray.2010

    • Author(s)
      祖父江和哉, ら
    • Journal Title

      Nutrition

      Volume: 27 Pages: 557-60

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel skin-traction method is effective for real-time ultrasound-guided internal jugular vein catheterization in infants and neonates weighing lessthan 5 kilograms2009

    • Author(s)
      Morita M, Sasano H, Azami T, Sasano N, Fujita Y, Ito S, Sugiura T, Sobue K
    • Journal Title

      Anesth Analg

      Volume: 109 Pages: 754-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Time progression from the patient's operating room entrance to incision : factors affecting anesthetic setup and surgicalpreparation times2009

    • Author(s)
      Sasano N, Morita M, Sugiura T, Sasano H, Tsuda T, Katsuya H
    • Journal Title

      J Anesth

      Volume: 23(2) Pages: 230-4

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous positive airway pressure applied through a bronchial blocker as a treatment for hypoxemia due to stenosis of the left main bronchus2009

    • Author(s)
      Sasano H, Sasano N, Ito S, Fujita Y, Sugiura T, Morita M, Sobue K
    • Journal Title

      Anesthesiology

      Volume: 110 Pages: 1199-200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excitation and sensitization of nociceptors by bradykinin : what do we know?2009

    • Author(s)
      Mizumura K, Sugiura T, Katanosaka K, Banik RK, Kozaki Y
    • Journal Title

      Exp BrainRes

      Volume: 196(1) Pages: 53-65

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Before-after study of a restricted fluid infusion strategy for management of donor hepatectomy for living-donorliver transplantation2009

    • Author(s)
      Fujita Y, Takeuchi A, Sugiura T, Hattori T, Sasano N, Mizuochi Y, Sobue K
    • Journal Title

      J Anesth

      Volume: 23 Pages: 67-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous positive airway pressure applied through a bronchial blocker as a treatment for hypoxemia due to stenosis of the left main bronchus2009

    • Author(s)
      杉浦健之, 祖父江和哉, ら
    • Journal Title

      Anesthesiology 110

      Pages: 1199-1200

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes2009

    • Author(s)
      祖父江和哉, ら
    • Journal Title

      Neurosci Lett. 469

      Pages: 109-112

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus2009

    • Author(s)
      祖父江和哉, ら
    • Journal Title

      J Pharmacol Exp Ther. 330

      Pages: 2-12

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] ドパミン作動薬が有効であった有痛性下肢運動障害疾患の一例2011

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      日本ペインクリニック学会第45回大会
    • Place of Presentation
      愛媛県松山市愛媛県県民文化会館
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 巨大ブラを有する患者に対する自発呼吸下腕神経叢ブロック併用全身麻酔の経験2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      徳島(徳島グランヴィリオホテル)
    • Year and Date
      2010-11-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 緊急気管切開術を必要とした、長期挿管管理による声門下気管狭窄の一症例2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      第18回日本集中治療医学会東海北陸地方会
    • Place of Presentation
      名古屋(ウインク愛知)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 常位胎盤早期剥離による帝王切開後に重症貧血となった抗Jra抗体、抗Dia抗体陽性の1症例2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      第18回日本集中治療医学会東海北陸地方会
    • Place of Presentation
      名古屋(ウインク愛知)
    • Year and Date
      2010-06-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] SepsisはLPS-CD14経路を介してMFG-E8を抑制しマクロファージのアポトーシス細胞貪食能を抑制する-新しい貪食作用の検出方法を用いた検討-2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経細胞におけるGM1ガングリオシド発現に対する麻酔薬の影響-アルツハイマー型認知症患者への麻酔薬使用は問題ないのか?-2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 先端形状の異なる硬膜外針の穿刺力に関する検討2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡(福岡国際会議場)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰部交感神経節ブロックを施行した肢端紅痛症の1例-ブロック後の経過を含めて-2010

    • Author(s)
      伊藤彰師、杉浦健之、鈴木悦子、幸村英文、草間宣好、水落雄一朗、薊隆文、大堀久、春原啓一、祖父江和哉
    • Organizer
      第21回日本ペインクリニック学会東海地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 多発性硬化症に伴う前胸部・下肢痛に対して脊髄刺激療法を施行した1例2010

    • Author(s)
      杉浦健之、木村卓二、島田靖子、徐民恵、平手博之、藤田義人、笹野信子、笹野寛、津田喬子、祖父江和哉
    • Organizer
      第21回日本ペインクリニック学会東海地方会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 多発性硬化症にともなう前胸部・下肢痛に対して脊髄刺激療法を施行した1例2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      第21回日本ペインクリニック学会東海地方会
    • Place of Presentation
      名古屋(第二豊田ビル)
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腰部交換神経節ブロックを施行した肢端紅痛症の1例-ブロック後の経過を含めて-2010

    • Author(s)
      杉浦健之、祖父江和哉, ら
    • Organizer
      第21回日本ペインクリニック学会東海地方会
    • Place of Presentation
      名古屋(第二豊田ビル)
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脊髄鎮痛で疼痛管理している仙骨脊索腫による難治性下肢痛の1症例2010

    • Author(s)
      徐民恵、杉浦健之、薊隆文、伊藤彰師、笹野寛、笹野信子、大堀、春原啓一、津田喬子、祖父江和哉
    • Organizer
      日本ペインクリニック学会第44回大会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] SepsisはLPS-CD14経路を介してMFG-E8を抑制しマクロファージのアポトーシス細胞貪食能を抑制する-新しい貪食作用の検出方法を用いた検討-2010

    • Author(s)
      幸村英文、MiksaMichael、Wang Ping、伊藤彰師、杉浦健之、祖父江和哉
    • Organizer
      日本麻酔科学会第57回学術集会
    • Place of Presentation
      福岡
    • Related Report
      2011 Final Research Report
  • [Presentation] 頸・背部の筋攣縮に伴う疼痛に対するA型ボツリヌス毒素製剤の治療効果2009

    • Author(s)
      杉浦健之, 祖父江和哉
    • Organizer
      日本ペインクリニック学会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-07-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 頸・背部の筋れん縮に伴う疼痛に対するA型ボツリヌス毒素製剤の治療効果2009

    • Author(s)
      杉浦健之、森田正人、平手博之、笹野寛、春原啓一、津田喬子、祖父江和哉
    • Organizer
      日本ペインクリニック学会第43回大会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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