| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
We have arranged experimental facility for in vivo patch-clamp method to record stable synaptic responses in rat spinal dorsal horn neurons. Spinal surface perfusion of nicotine dose-dependently increased the frequency and amplitude of inhibitory post-synaptic currents in rat dorsal horn neurons of spinal cord suggesting one of the nicotine's analgesic mechanisms in the spinal cord. However, intravenous administration of nicotine had no obvious effects on IPSCs. Actions of nicotine on excitatory post-synaptic currents, action potentials, and responses in acute pain model are yet to be determined.
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