Study on neuropathic pain associated with pre-diabetes and obese

• Project/Area Number: 21592023
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Nigata University of Phermacy and Applied Life Sciences (2011); Wakayama Medical University (2009-2010)
• Principal Investigator: MAEDA Takehiko 新潟薬科大学, 薬学部, 教授 (50271010)
• Co-Investigator(Kenkyū-buntansha): KISHIOKA Shiroh 和歌山県立医科大学, 医学部, 教授 (60137255) ; KIGUCHI Norikazu 和歌山県立医科大学, 医学部, 講師 (90433341) ; KOBAYASHI Yuka 和歌山県立医科大学, 医学部, 助教 (20511562)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 疼痛管理学 / 生活習慣病 / アディポカイン / アロディニア / 脂肪細胞 / 高脂肪食 / レプチン / 神経障害性疼痛 / 坐骨神経

Research Abstract

We established a model for pre-diabetes with neuropathic pain(PDN). The model showed peripheral neuropathy, characterized by allodynia and histopathology associated with chronic inflammation. The model is useful for development of therapeutic treatment for PDN.

Research Products

• [Journal Article] Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice (2011)
  • Author(s): Ueno K
  • Journal Title: Drug Discoveries & Therapeutics Volume: 5 Issue: 2 Pages: 71-75
  • DOI: 10.5582/ddt.2011.v5.2.71
  • NAID: 130005054697
  • ISSN: 1881-7831, 1881-784X
  • Peer Reviewed
• [Journal Article] Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation (2011)
  • Author(s): Yamamoto A
  • Journal Title: Life Sci Volume: 89 Issue: 25-26 Pages: 956-961
  • DOI: 10.1016/j.lfs.2011.10.004
  • Peer Reviewed
• [Journal Article] レプチンと神経障害性疼痛 (2010)
  • Author(s): 前田武彦
  • Journal Title: 医学のあゆみ Volume: 233(7) Pages: 565-565
• [Journal Article] Macrophage inflammatory protein-1 α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation (2010)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, Fukazawa Y, Kishioka S
  • Journal Title: Pain Volume: 149 Pages: 305-315
  • URL: http://dx.doi.org/10.1016/j.pain.2010.02.025
  • Peer Reviewed
• [Journal Article] Macrophage inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1β up-regulation (2010)
  • Author(s): Kiguchi N, Maeda T, et al.
  • Journal Title: Pain Volume: 149(2) Pages: 305-315
  • Peer Reviewed
• [Journal Article] Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice (2010)
  • Author(s): Maeda T, et al.
  • Journal Title: Biol.Pharm.Bull. Volume: 33(6) Pages: 1011-1014
  • NAID: 130000247970
  • Peer Reviewed
• [Journal Article] CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain (2010)
  • Author(s): Kiguchi N, Kobayashi Y, Maeda T, et al.
  • Journal Title: Neurosci.Lett. Volume: 484 Pages: 17-21
  • Peer Reviewed
• [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation (2009)
  • Author(s): Maeda T, Kiguchi N, Kobayashi Y, Ikuta T, Ozaki M, Kishioka S
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 106 Issue: 31 Pages: 13076-13081
  • DOI: 10.1073/pnas.0903524106
  • Peer Reviewed
• [Journal Article] Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation (2009)
  • Author(s): Maeda T, Kiguchi N, Kobayashi Y, et al.
  • Journal Title: Proc.Natl.Acad.Sci.USA 106(31) Pages: 13076-13081
  • Peer Reviewed
• [Journal Article] Leptin enhances CC-chemokine ligand expression in cultured murine macrophage (2009)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Biochem.Biophys.Res.Commun. 384(3) Pages: 311-315
  • Peer Reviewed
• [Journal Article] Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice (2009)
  • Author(s): Kiguchi N, Maeda T, Kobayashi Y, et al.
  • Journal Title: Anesth.Analg. 109(4) Pages: 1305-1311
  • Peer Reviewed
• [Presentation] 緩和医療における臨床研究・基礎研究とは (2011)
  • Author(s): 前田武彦
  • Organizer: 第61回日本薬学会近畿支部総会
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-22
• [Presentation] 緩和医療における臨床研究・基礎研究とは (2011)
  • Author(s): 前田武彦
  • Organizer: 第61回日本薬学会近畿支部総会・大会
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-22
• [Presentation] Effect of capsaicin on neuropathic pain through the modulation of interaction of adipocytes and macrophages (2011)
  • Author(s): 前田武彦, 他
  • Organizer: 第84回日本薬理学会
  • Place of Presentation: (誌上開催)
  • Year and Date: 2011-03-22
• [Presentation] Macrophage inflammatory protein-1α mediates the pathgenesis of neuropathic pain (2010)
  • Author(s): Kiguchi N, Maeda T, et al.
  • Organizer: Neuroscience2010
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-14
• [Presentation] Leptin and neuropathic pain (2010)
  • Author(s): Kishioka S, Maeda T
  • Organizer: Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
  • Place of Presentation: Calabria, Italy
  • Year and Date: 2010-09-24
• [Presentation] Role of macrophage inflammatory protein-1 in the pathogenesis of neuropathic pain (2010)
  • Author(s): Kiguchi N, Maeda T, et al.
  • Organizer: Molecular Targets for Novel Pain Therapeutics From basic research to clinical translation
  • Place of Presentation: Calabria, Italy
  • Year and Date: 2010-09-24
• [Presentation] Macrophage inflammatory protein-1α plays a key role in the development of neuropathic pain (2010)
  • Author(s): Kiguchi N, Maeda T, et al.
  • Organizer: New Perspectives in Neuroscience : Joint Meeting of Young Italian and Japanese Neuroscientists
  • Place of Presentation: Naples, Italy
  • Year and Date: 2010-09-21
• [Presentation] Macropharge inflammatory protein-1α mediates the development of neuropathic pain following peripheral nerve injury (2010)
  • Author(s): 木口倫一、前田武彦, 他
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-02
• [Presentation] 神経障害性疼痛におけるHMGB1の関与 (2010)
  • Author(s): 前田武彦, 他
  • Organizer: 第31回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-08-27
• [Presentation] 神経障害性疼痛形成におけるMIP-2の役割 (2010)
  • Author(s): 木口倫一、前田武彦, 他
  • Organizer: 第31回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2010-08-27
• [Presentation] レプチンの神経障害性疼痛における役割 (2010)
  • Author(s): 前田武彦、木口倫一、小林悠佳、岸岡史郎
  • Organizer: 第15回アディポサイエンス研究会シンポジウム
  • Place of Presentation: 吹田
  • Year and Date: 2010-08-25
• [Presentation] レプチンの神経障害性疼痛における役割 (2010)
  • Author(s): 前田武彦, 他
  • Organizer: 第15回アディポサイエンス研究会シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2010-08-21
• [Presentation] 神経障害性疼痛におけるマクロファージ活性化および脂肪細胞肥大化に及ぼすカプサイシンの影響 (2010)
  • Author(s): 前田武彦, 他
  • Organizer: 第117回日本薬理学会近畿部会
  • Place of Presentation: 徳島
  • Year and Date: 2010-07-08
• [Presentation] HMGB1によるレプチンシグナル活性化は神経障害性疼痛の形成に関与する (2010)
  • Author(s): 前田武彦, 木口倫一, 小林悠佳, 岸岡史郎
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] アディポカインは神経障害性疼痛の形成を調節する (2009)
  • Author(s): 前田武彦、岸岡史郎
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-03-19
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html
• [Remarks]
  • URL: http://www.wakayama-med.ac.jp/dept/igakubu/160416/index.html