The effects of the gene expression of D-serine related enzymes on psychiatric symptom induced by ketamine

• Project/Area Number: 21592026
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Tokai University
• Principal Investigator: TAKEYAMA Kazuhide 東海大学, 医学部, 准教授 (80256148)
• Co-Investigator(Kenkyū-buntansha): YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ケタミン / 精神症状 / NMDA受容体 / Dセリン / 遺伝子発現 / 鎮痛作用 / 下行性痛覚抑制経路 / セリンラセマーゼ / Dアミノ酸酸化酵素 / 統合失調症 / Ataxia

Research Abstract

The levels of serine racemase mRNAs in forebrain areas significantly decreased after subchronic administration of ketamine. In contrast, subchronic ketamine administration produced a significant increase in the mRNA expression of D-amino acid oxidase in the midbrain. These findings suggest that there is a relationship be-tween the gene expression of the D-serine-related enzymes and the blockade of the NMDA receptors.

Research Products

• [Journal Article] Diazepam Enhances Production of Diazepam-Binding Inhibitor(DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland (2011)
  • Author(s): Tsukagoshi E, Shinomiya T, Yoshikawa M, Kawano T, Okubo M, Sawaki K
  • Journal Title: J Pharmacol Sci Volume: 115 Pages: 221-229
  • NAID: 10029892190
  • Peer Reviewed
• [Journal Article] Diazepam Enhances Production of Diazepam-Binding Inhibitor (DBI), a Negative Saliva Secretion Regulator, Localized in Rat Salivary Gland (2011)
  • Author(s): Tsukagashi E., Shinomiya T., Yoshikawa M., et al
  • Journal Title: Journal of Pharmacological Science Volume: 115 Pages: 221-229
  • NAID: 10029892190
  • Peer Reviewed
• [Journal Article] Subchronic Administration of Ketamine Decreases the mRNA Expression of Serine Racemase in Rat Brain (2010)
  • Author(s): Watanabe M, Yoshikawa M, Takeyama K, Hashimoto A, Kobayashi H, Suzuki T
  • Journal Title: Tokai J Exp Clin Med Volume: 35(4) Pages: 137-173
  • Peer Reviewed
• [Journal Article] Cysteinyl leukotriene receptor antagonists inhibit tumor metastasis by inhibiting capillary permeability (2010)
  • Author(s): Nozaki M, Yoshikawa M, Ishitani K, Kobayashi H, Houkin K, Imai K, Ito Y, Muraki T
  • Journal Title: Keio J Med Volume: 59 Pages: 10-18
  • NAID: 10026203480
  • Peer Reviewed
• [Journal Article] Subchronic administration of Ketamine decreases the mRNA expression of serine racemase in rat brain (2010)
  • Author(s): M.Watanabe, M.Yoshikawa, K.Takeyama, et al
  • Journal Title: Tokai Journal of Experimental and Clinical Medicine Volume: 35 Pages: 137-143
  • Peer Reviewed
• [Presentation] Effects of three peptidase inhibitors on antinosiceptive action of Dynoephin A by intrathecal administration in rat (2012)
  • Author(s): Ajimi J, Miura M, Takahashi S, Watanabe M, Yoshikawa M, Suzuki T
  • Organizer: 2011年度日本薬理学会年会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2012-03-16
• [Presentation] Oral Mucositis resulting from irradiation (2012)
  • Author(s): 吉川正信
  • Organizer: The 85^<th> Annual Meeting of the Japanese Pharmacological Society
  • Place of Presentation: 京都国際会館(招待講演)
  • Year and Date: 2012-03-16
• [Presentation] セボフルランのラット髄腔内投与による抗侵害効果の検討 (2011)
  • Author(s): 金澤正浩、村田智彦、吉川正信、鈴木利保
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸ポートピア(神戸)
  • Year and Date: 2011-05-20
• [Presentation] ラット髄腔内に投与したペプチド分解酵素阻害剤によるロイシンエンケファリンの鎮痛効果の増強 (2011)
  • Author(s): 三浦正明、渡邊真理子、高橋滋、吉川正信、鈴木利保
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸ポートピア(神戸)
  • Year and Date: 2011-05-20
• [Presentation] Subchronic administration of ketamine decreases the mRNA expression of serine racemase in rat brain (2011)
  • Author(s): Watanabe M, Yoshikawa M, Suzuki T, Takeyama K, Takahashi S
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸ポートピア(神戸)
  • Year and Date: 2011-05-20
• [Presentation] メチオニンエンケファリンの鎮痛効果に及ぼすオピオイドペプチド分解酵素阻害剤の影響 (2011)
  • Author(s): 村田智彦、渡邊真理子、松田光正、吉川正信、高橋滋、鈴木利保
  • Organizer: 日本麻酔科学会第58回学術集会
  • Place of Presentation: 神戸ポートピア(神戸)
  • Year and Date: 2011-05-19
• [Presentation] D-Methionine as a protector for irradiation-oral mucositis (2010)
  • Author(s): Yoshikawa M, Cotrim PA, Sower AL, Mitchell JB, Baum BJ
  • Organizer: 39th Annual Meetng of American Asociation of Dental Research. Washington D. C. Convention Center
  • Place of Presentation: USA, Washington D. C.
  • Year and Date: 2010-03-06
• [Presentation] The change of upper limbs PVI in spinal block(The comparison in high spinal block and non-high spinal block) (2009)
  • Author(s): Takeyama K, Yoshikawa M, Suzuki T.
  • Organizer: Euroanesthesia
  • Place of Presentation: Milano Convention Center(Italia Milano)
  • Year and Date: 2009-06-07
• [Presentation] The change of upper limbs PVI in spinal block(The comparison in high spinal block and non-high spinal block) (2009)
  • Author(s): K.Takeyama, M.Yoshikawa, T.Suzuki
  • Organizer: Euroanesthesia 2009
  • Place of Presentation: Milano Convention Center
  • Year and Date: 2009-06-07