The effects of the gene expression of D-serine related enzymes on psychiatric symptom induced by ketamine
Project/Area Number |
21592026
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Anesthesiology/Resuscitation studies
|
Research Institution | Tokai University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
YOSHIKAWA Masanobu 東海大学, 医学部, 准教授 (90276791)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | ケタミン / 精神症状 / NMDA受容体 / Dセリン / 遺伝子発現 / 鎮痛作用 / 下行性痛覚抑制経路 / セリンラセマーゼ / Dアミノ酸酸化酵素 / 統合失調症 / Ataxia |
Research Abstract |
The levels of serine racemase mRNAs in forebrain areas significantly decreased after subchronic administration of ketamine. In contrast, subchronic ketamine administration produced a significant increase in the mRNA expression of D-amino acid oxidase in the midbrain. These findings suggest that there is a relationship be-tween the gene expression of the D-serine-related enzymes and the blockade of the NMDA receptors.
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Report
(4 results)
Research Products
(14 results)