Prevention for the occurrence of the secondary pulmonary embolism related to the endothelial damage of pulmonary vasculature.

• Project/Area Number: 21592027
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kurume University
• Principal Investigator: WATANABE Seiji 久留米大学, 医学部, 准教授 (10201196)
• Co-Investigator(Kenkyū-buntansha): HIRAKI Teruyuki 久留米大学, 医学部, 助教 (30320237)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肺血栓塞栓症 / 血管内皮障害 / 活性化血小板 / 経食道心臓超音波検査 / 血管反応性

Research Abstract

Pulmonary embolism was related to the endothelial damage of pulmonary vasculature on the day after surgery. Intravenous injection of flurbiprofen at the end of the surgery presents the possibility of the prevention of the secondary pulmonary embolism.

Research Products

• [Journal Article] Propofol protects against Anandamide-induced injury in human umbilical vein endothelial cells (2011)
  • Author(s): Ito T, Mishima Y, Ito A, Kameyama N, Harada H, Iwata O, Watanabe S, Ushijima K.
  • Journal Title: Kurume Medical Journal Volume: 58 Pages: 15-30
  • NAID: 130001444130
  • Peer Reviewed
• [Journal Article] Anesthetic management of patient with deteriorated cardiac function following cardio pulmonary resuscitation (2010)
  • Author(s): Nagata T, Mishima Y, Ito T, Sawada M, Hiraki T, Hamada N, Miyawaki N, Ito A, Watanabe S, Ushijima K
  • Journal Title: Kurume Medical Journal Volume: 57 Pages: 81-84
  • NAID: 130000441796
  • Peer Reviewed
• [Journal Article] Gradient of bronchial end-tidal CO2 on two-lung ventilation in lateral decubitus position is predictive of an oxygen disorder on subsequent one-lung ventilation (2009)
  • Author(s): Yamamoto Y, Watanabe S, Kano T.
  • Journal Title: J Anesth Volume: 23 Pages: 192-197
  • Peer Reviewed
• [Presentation] Propofol prevents anandamide-induved cell death in endothelial cells (2009)
  • Author(s): Ito T, Mishima Y, Watanabe S, Harada H, Kano T
  • Organizer: IARS Annual Meeting
  • Place of Presentation: San Diego
• [Presentation] Systolic anterior motion of the mitral valve developed in the intensive care unit after mitral valve plasty in the patient with Noonan syndrome (2009)
  • Author(s): Gotanda Y, Ito A, Mishima Y, Kameyama N, Yokomizo T, Watanabe S, Ushijima K
  • Organizer: Annual meeting of Asian cardiovascular anesthesia
  • Place of Presentation: Tokyo
• [Presentation] Propofol prevents against anandamide-induced apoptosis via non-connabinoid receptor-mediated mechanism (2009)
  • Author(s): Kameyama N, Mishima Y, Itoh T, Watanabe S, Harada H, Kano T
  • Organizer: ASA Annual meeting
  • Place of Presentation: New Orleans