Development of intracrine androgen deprivation therapy for prostate cancer

• Project/Area Number: 21592035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Urology
• Research Institution: Niigata University
• Principal Investigator: NISHIYAMA Tsutomu 新潟大学, 医歯学系, 准教授 (70208239)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 前立腺癌 / アンドロゲン抑制療法 / アンドロゲン代謝 / 細胞内分泌学 / 細胞内アンドロゲン代謝 / ジヒドロテストステロン / デヒドロエピアンドロステロン / HSD17B6 / 3αアンドロスタンディオール / アンドロゲン受容体 / 下垂体-副腎内分泌軸

Research Abstract

The androgen milieu in men with high Gleason score prostate cancer is probably less affected by conventional androgen deprivation therapy than that in men with low score cancer, which was suggested to be associated with adrenal androgen levels. In patients treated with androgen deprivation therapy the pituitary-adrenal axis mediated by adrenocorticotropic hormone、in addition dehydroepiandrosterone-dihydrotestosterone axis has a central role in the regulation of androgen synthesis.

Research Products

• [Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer (2012)
  • Author(s): Nishiyama T
  • Journal Title: J Steroid Biochem Mol Biol Volume: 129(3-5) Pages: 179-90
  • Peer Reviewed
• [Journal Article] Androgen deprivation therapy in combination with radiotherapy for high-risk clinically localized prostate cancer (2012)
  • Author(s): Nishiyama T
  • Journal Title: J steroid Biochem Mol Biol.2012 Apr; 129(3-5) : 179-90 Volume: 129 Pages: 179-190
  • Peer Reviewed
• [Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy. (2011)
  • Author(s): Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K.
  • Journal Title: Prostate Volume: (In press) Issue: 11 Pages: 1207-1213
  • DOI: 10.1002/pros.22471
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer (2011)
  • Author(s): Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K
  • Journal Title: Urol Oncol
  • Peer Reviewed
• [Journal Article] II臨床6)内分泌療法c.内分泌療法の新展開d)アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤日本臨牀69巻増刊号5前立腺癌(第2版) (2011)
  • Author(s): 西山勉
  • Journal Title: 日本臨牀
• [Journal Article] 前立腺癌ホルモン環境概念のパラダイムシフト (2011)
  • Author(s): 西山勉
  • Journal Title: 新潟医学会雑誌 Volume: 125 Pages: 581-601
  • NAID: 120006748441
• [Journal Article] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤 (2011)
  • Author(s): 西山勉
  • Journal Title: 日本臨床 Volume: 69 Suppl 5 Pages: 511-515
• [Journal Article] Insulin-like growth factorl is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer. (2011)
  • Author(s): Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
  • Journal Title: Urol Oncol.2011 Mar 30 Volume: (電子版 Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Prostate cancer and androgens : new strategies of androgen deprivation therapy (2010)
  • Author(s): Nishiyama T
  • Journal Title: Curr Top Steroid Res Volume: 7 Pages: 35-45
  • Peer Reviewed
• [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving androgen deprivation therapy(ADT): impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis (2010)
  • Author(s): Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K
  • Journal Title: Prostate Volume: 70(2) Pages: 155-61
  • Peer Reviewed
• [Journal Article] Decline of the red blood cell count in patients receiving androgen deprivation therapy for localized prostate cancer : impact of ADT on insulin-like growth factor-1 and erythropoiesis (2010)
  • Author(s): Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K
  • Journal Title: Urology Volume: 75(6) Pages: 1441-5
  • Peer Reviewed
• [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu (2010)
  • Author(s): Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K
  • Journal Title: Prostate Volume: 70(13) Pages: 1395-401
  • Peer Reviewed
• [Journal Article] an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells (2010)
  • Author(s): Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K. Trilostane
  • Journal Title: Cancer Lett Volume: 297(2) Pages: 226-30
  • Peer Reviewed
• [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer (2010)
  • Author(s): Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K
  • Journal Title: J Urol Volume: 184(5) Pages: 1971-6
  • Peer Reviewed
• [Journal Article] Serum prostate-specific antigen levels reflect the androgen milieu in patients with localized prostate cancer receiving androgen deprivation therapy : Tumor malignant potential and androgen milieu. (2010)
  • Author(s): Takizawa I, Nishiyama T, Hara N, Isahaya E, Hoshii T, Takahashi K.
  • Journal Title: Prostate.70(13)1395-401, 2010. Volume: 70 Pages: 1395-1401
  • Peer Reviewed
• [Journal Article] Trilostane, an inhibitor of 3β-hydroxysteroid dehydrogenase, has an agonistic activity on androgen receptor in human prostate cancer cells. (2010)
  • Author(s): Takizawa I, Nishiyama T, Hara N, Hoshii T, Ishizaki F, Miyashiro Y, Takahashi K.
  • Journal Title: Cancer Lett.297(2)226-30, 2010. Volume: 297 Pages: 226-230
  • Peer Reviewed
• [Journal Article] Adrenocorticotropic hormone is involved in regulation of androgen synthesis in men receiving androgen deprivation therapy for localized prostate cancer. (2010)
  • Author(s): Takizawa I, Hara N, Nishiyama T, Isahaya E, Hoshii T, Takahashi K.
  • Journal Title: JUrol.184(5), 2010. Volume: 184 Pages: 1971-1976
  • Peer Reviewed
• [Journal Article] Bone metabolic disorder in patients with prostate cancer receiving and rogen deprivation therapy(ADT) : impact of ADT on the growth hormone/insulin-like growth factor-1/parathyroid hormone axis. (2010)
  • Author(s): Isahaya E, Hara N, Nishiyama T, Hoshii T, Takizawa I, Takahashi K.
  • Journal Title: Prostate. 2010 Feb 1 ; 70(2): 70 Pages: 155-161
  • Peer Reviewed
• [Journal Article] Decline of the Red Blood Cell Count in Patients Receiving Androgen Deprivation Therapy for Localized Prostate Cancer : Impact of ADT on Insul in-like Growth Factor-1 and Erythropoiesis. (2010)
  • Author(s): Hara N, Nishiyama T, Takizawa I, Saito T, Kitamura Y, Takahashi K.
  • Journal Title: Urology. 75(印刷中)
  • Peer Reviewed
• [Journal Article] 前立腺癌とアンドロゲン-アンドロゲン抑制療法の新たな挑戦 (2009)
  • Author(s): 西山勉
  • Journal Title: Urology Today Volume: 16(2) Pages: 50-54
• [Journal Article] Altered association of interleukin-6 with sex steroids in lipid metabolism disorder in men with prostate cancer receiving androgen deprivation therapy
  • Author(s): Komatsu S, Hara N, Ishizaki F, Nishiyama T, Takizawa I, Isahaya E, Kawasaki T, Takahashi K
  • Journal Title: Prostate.2011 Dec 27.doi : 10.1002/pros.22471 Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)
  • Peer Reviewed
• [Journal Article] Insulin-like growth factor-1 is associated with regulation of the luteinizing hormone production in men receiving androgen deprivation therapy with gonadotropin-releasing hormone analogues for localized prostate cancer
  • Author(s): Hara N, Takizawa I, Isahaya E, Nishiyama T, Hoshii T, Ishizaki F, Takahashi K.
  • Journal Title: Urol Oncol.2011 Mar 30 Volume: (Epub ahead of print)(未定)(Online先行掲載)(印刷中)
  • Peer Reviewed
• [Presentation] スポンサードセミナー「前立腺組織内環境からみた前立腺癌アンドロゲン抑制療法」 (2011)
  • Author(s): 西山勉
  • Organizer: 第63回日本泌尿器科学会西日本総会
  • Place of Presentation: 久留米
  • Year and Date: 2011-11-12
• [Presentation] 5 a-androstane-3a 17b-diol will be a p otential precursor of the most active androgen 5a-dihydrotestosterone in prostate cancer (2011)
  • Author(s): Nishiyama T, Ishizaki F, Hara N, K awasaki T, Miyashiro Y, Takizawa I, Hoshii T, Naito M, Takahashi K
  • Organizer: AUA annual meeting
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2011-05-15
• [Presentation] 5 α ANDROSTANE-3 α 17 β-DIOL WILL BE A POTENTIAL PRECURSOR OF THE MOST ACTIVE ANDROGEN 5 α-DIHYDROTESTOSTERONE IN PROSTATE CANCER (2011)
  • Author(s): Tsutomu Nishiyama, Fumio Ishizaki, Itsuhiro Takizawa, Kazutoshi Yamana, Noboru Hara, Kota Takahashi
  • Organizer: American Urological Association 2011 annual meeting
  • Place of Presentation: Washington, USA. Walter E.Washington Convertion Center
  • Year and Date: 2011-05-15
• [Presentation] アンドロゲン合成阻害剤と新規アンドロゲン受容体拮抗剤 (2010)
  • Author(s): 西山勉
  • Organizer: 第17回東京前立腺がんフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2010-10-09
• [Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift (2010)
  • Author(s): 西山勉
  • Organizer: 第75回日本泌尿器科学会東部総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-09-17
• [Presentation] ホルモン抵抗性前立腺癌概念のparadigm shift (2010)
  • Author(s): 西山勉
  • Organizer: 日本泌尿器科学会東部総会教育講演
  • Place of Presentation: 宇都宮
  • Year and Date: 2010-09-17
• [Presentation] an inhibitor of 3β-HSD, has an agonistic activity for androge n receptors in the prostate cancer ce lls (2010)
  • Author(s): Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K, Trilostane
  • Organizer: AUA annual meeting
  • Place of Presentation: San Franci sco, USA
  • Year and Date: 2010-05-30
• [Presentation] Trilostane, an inhibitor of 3β-HSD, has an agonistic activity for androgen receptors in the prostate cancer cells. (2010)
  • Author(s): Nishiyama T, Takizawa I, Hoshii T, Kasahara T, Hara N, Takahashi K
  • Organizer: アメリカ泌尿器科学会年次総会
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2010-05-30
• [Presentation] The expression features o f androgen-metabolic genes involving intracrine production of androgens i n the prostate cancer cells (2009)
  • Author(s): Nishiyama T, Hara N, Yamana K, K Suzuki K, Hoshii T, Takizawa I, Ta kahashi K.
  • Organizer: AUA annual meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 2009-04-26
• [Presentation] The expression features of androgen- metabolic genes involving intracrine production of androgens in the prostate cancer cells (2009)
  • Author(s): 西山勉
  • Organizer: アメリカ泌尿器科学会年次総会
  • Place of Presentation: シカゴ
  • Year and Date: 2009-04-26
• [Book] Paradigm shift in the concept of hormonal milieu of prostate cancer. In Prostate Cancer-From Bench to Bedside.(Spiess PE ed.) (2011)
  • Author(s): Nishiyama T
  • Publisher: In Tech. Croatia
• [Book] Paradigm shift in the concept of hormonal milieu of prostate cancer.In Spiess PE ed.PROSTATE CANCER FROM ENCH TO BEDSIDE.Croatia, InTech, 2011 (2011)
  • Author(s): Tsutomu Nishiyama
  • Publisher: InTech